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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DA612149 is the fusion of parental proteins PAM16, TSPAN3 (from a repository: Thu Apr 6 16:36:57 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins12 (20.69 %)
The number (and %) of the tumor suppressors4 (6.90 %)
Total number of binary PPIs (saturation %)97 (5.87 %)
The number (and %) of affected PPIs57 (58.76 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI2.931
Assortativity coefficient-0.5368
The network average Clustering coefficient0.432
The number (and %) of a zero Clustering coefficients26 (44.83 %)
The number (and %) of a zero Betweenness Centrality42 (72.41 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PAM16,TSPAN3 All fusions
: DA612149;
Proteins found in more fusions GABARAP (see 2 fusions); FGFR2 (see 3 fusions); CEP70 (see 1 fusions); EWSR1 (see 2 fusions); CSNK1G3 (see 1 fusions); FGFR1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DA612149chimera570.0183100.333Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Pam16 (PF03656): Pam16
Tetraspannin (PF00335, IPR018499): Tetraspanin family
2 ACVR1Boncoprotein100Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
3 AGPAT3interactor21.0000Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
Acyltransf_C (PF16076, IPR032098): Acyltransferase C-terminus
4 ANTXR1interactor21.0000Ant_C (PF05586, IPR008399): Anthrax receptor C-terminus region
Anth_Ig (PF05587, IPR008400): Anthrax receptor extracellular domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
5 ARL17Ainteractor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
ARL17 (PF15840, IPR031687): ADP-ribosylation factor-like protein 17
6 ARL6IP1interactor200Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
7 BLOC1S2interactor100BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
XhlA (PF10779, IPR019715): Haemolysin XhlA
8 CC2D1Ainteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Snf7 (PF03357, IPR005024): Snf7
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
LELP1 (PF15042, IPR026076): Late cornified envelope-like proline-rich protein 1
9 CCDC58interactor31.0000Cid2 (PF09774, IPR019171): Caffeine-induced death protein 2
10 CD320interactor100Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF3678 (PF12435, IPR022146): Protein of unknown function (DUF3678)
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
11 CD63interactor30.6671.000Tetraspannin (PF00335, IPR018499): Tetraspanin family
DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
12 CDC6oncoprotein100Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
13 CEP70protein found in more fusions200IncA (PF04156, IPR007285): IncA protein
Mog1 (PF04603, IPR007681): Ran-interacting Mog1 protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin
14 COQ9interactor60.5004.667COQ9 (PF08511, IPR013718): COQ9
15 CSNK1G3protein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
CK1gamma_C (PF12605, IPR022247): Casein kinase 1 gamma C terminal
16 DNAJC15interactor40.6671.000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF3918 (PF13056, IPR025029): Protein of unknown function (DUF3918)
17 DNAJC19interactor50.4005.667DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
18 DNMT3Bsuppressor100DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
19 EIF3Concoprotein100eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
PCI (PF01399, IPR000717, SM00088): PCI domain
20 EPHA4interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
SusE (PF14292, IPR025970): SusE outer membrane protein
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
21 EPHA5interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
22 ERGIC3oncoprotein21.0000COPIIcoated_ERV (PF07970, IPR012936): Endoplasmic reticulum vesicle transporter
ERGIC_N (PF13850): Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
23 EWSR1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
24 FAM189Binteractor21.0000CD20 (PF04103, IPR007237): CD20-like family
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
25 FEZ1interactor200FEZ (PF07763, IPR011680): FEZ-like protein
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
26 FGFR1oncoprotein31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
27 FGFR2oncoprotein200Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
28 GABARAPsuppressor31.0000Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
29 GOLGA7interactor100Erf4 (PF10256, IPR019383): Golgin subfamily A member 7/ERF4 family
30 GPM6Ainteractor30.6671.000Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
DUF2701 (PF10857, IPR022586): Protein of unknown function (DUF2701)
31 IFNGR1interactor21.0000IFNGR1 (PF07140, IPR021126): Interferon gamma receptor (IFNGR1)
Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
32 KDSRoncoprotein1007kD_coat (PF02495, IPR003411): 7kD viral coat protein
adh_short (PF00106, IPR002198): short chain dehydrogenase
33 LPAR1oncoprotein21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
34 LRP10interactor100CUB (PF00431, IPR000859, SM00042): CUB domain
Syndecan (PF01034, IPR027789): Syndecan domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
35 MAP1LC3B2interactor100Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
36 MRFAP1interactor100MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
37 NDFIP1interactor30.6671.000DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Comm (PF15957, IPR031878): Commissureless
38 NDFIP2interactor100DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
39 NOTCH3suppressor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
40 PGRMC1interactor21.0000Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
SlyX (PF04102, IPR007236): SlyX
SCNM1_acidic (PF15805, IPR031625): Acidic C-terminal region of sodium channel modifier 1 SCNM1
41 PI4K2Ainteractor21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
42 PTPMT1interactor50.6672.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
43 RDH14interactor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
44 RNF13interactor30.6671.000DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
45 RNF149interactor21.0000PA (PF02225, IPR003137): PA domain
UPF0233 (PF06781, IPR009619): Uncharacterised protein family (UPF0233)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
46 SDCBPinteractor30.6671.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
47 SNX17interactor100FERM_M (PF00373, IPR019748): FERM central domain
PX (PF00787, IPR001683, SM00312): PX domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
48 SPACA1interactor30.6671.000DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
49 STX6interactor100Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
50 TEX29interactor30.6671.000Connexin (PF00029, IPR013092, SM00037): Connexin
TEX29 (PF15839, IPR031685): Testis-expressed sequence 29 protein
51 TIMM17Ainteractor40.5002.667Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
52 TIMM17Binteractor21.0000Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
53 TIMM44interactor40.6671.667Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
RecG_N (PF17190): RecG N-terminal helical domain
54 TMOD2interactor100Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
Tropomodulin (PF03250, IPR004934): Tropomodulin
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
55 TMOD3interactor100Tropomodulin (PF03250, IPR004934): Tropomodulin
Usher (PF00577, IPR000015): Outer membrane usher protein
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
56 TNFRSF10Bsuppressor60.33310.000Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
57 UGCGinteractor21.0000Glyco_transf_21 (PF13506, IPR025993): Glycosyl transferase family 21
58 ZDHHC9interactor30.6671.000UPF0182 (PF03699, IPR005372): Uncharacterised protein family (UPF0182)
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
DUF4714 (PF15833, IPR031674): Domain of unknown function (DUF4714)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 C15orf48interactorB12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
2 C2orf47interactorTim44 (PF04280, IPR007379, SM00978): Tim44-like domain
3 NDUFA4interactorB12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
4 PAM16parental proteinPam16 (PF03656): Pam16
5 TSPAN3parental proteinHum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family

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