Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DA612149 is the fusion of parental proteins PAM16, TSPAN3 (from a repository: Thu Apr 6 16:36:57 2017)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins12 (20.69 %)
The number (and %) of the tumor suppressors4 (6.90 %)
Total number of binary PPIs (saturation %)97 (5.87 %)
The number (and %) of affected PPIs57 (58.76 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI2.931
Assortativity coefficient-0.5368
The network average Clustering coefficient0.432
The number (and %) of a zero Clustering coefficients26 (44.83 %)
The number (and %) of a zero Betweenness Centrality42 (72.41 %)


List of the fusions

PPI for parental proteins: CORO7-PAM16,TSPAN3 All fusions
: DA612149;
Proteins found in more fusions GABARAP (see 2 fusions); FGFR2 (see 3 fusions); CEP70 (see 1 fusions); EWSR1 (see 2 fusions); CSNK1G3 (see 1 fusions); FGFR1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 DA612149chimera570.0183100.333Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Pam16 (PF03656): Pam16
Tetraspannin (PF00335, IPR018499): Tetraspanin family
2 ACVR1Boncoprotein100Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
3 AGPAT3interactor21.0000Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
Acyltransf_C (PF16076, IPR032098): Acyltransferase C-terminus
4 ANTXR1interactor21.0000Ant_C (PF05586, IPR008399): Anthrax receptor C-terminus region
Anth_Ig (PF05587, IPR008400): Anthrax receptor extracellular domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
5 ARL17Ainteractor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
ARL17 (PF15840, IPR031687): ADP-ribosylation factor-like protein 17
6 ARL6IP1interactor200Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
7 BLOC1S2interactor100BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
XhlA (PF10779, IPR019715): Haemolysin XhlA
8 CC2D1Ainteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Snf7 (PF03357, IPR005024): Snf7
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
LELP1 (PF15042, IPR026076): Late cornified envelope-like proline-rich protein 1
9 CCDC58interactor31.0000Cid2 (PF09774, IPR019171): Caffeine-induced death protein 2
10 CD320interactor100Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF3678 (PF12435, IPR022146): Protein of unknown function (DUF3678)
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
11 CD63interactor30.6671.000Tetraspannin (PF00335, IPR018499): Tetraspanin family
DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
12 CDC6oncoprotein100Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
13 CEP70protein found in more fusions200IncA (PF04156, IPR007285): IncA protein
Mog1 (PF04603, IPR007681): Ran-interacting Mog1 protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin
14 COQ9interactor60.5004.667COQ9 (PF08511, IPR013718): COQ9
15 CSNK1G3protein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
CK1gamma_C (PF12605, IPR022247): Casein kinase 1 gamma C terminal
16 DNAJC15interactor40.6671.000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF3918 (PF13056, IPR025029): Protein of unknown function (DUF3918)
17 DNAJC19interactor50.4005.667DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
18 DNMT3Bsuppressor100DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
19 EIF3Concoprotein100eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
PCI (PF01399, IPR000717, SM00088): PCI domain
20 EPHA4interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
SusE (PF14292, IPR025970): SusE outer membrane protein
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
21 EPHA5interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
22 ERGIC3oncoprotein21.0000COPIIcoated_ERV (PF07970, IPR012936): Endoplasmic reticulum vesicle transporter
ERGIC_N (PF13850): Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
23 EWSR1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
24 FAM189Binteractor21.0000CD20 (PF04103, IPR007237): CD20-like family
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
25 FEZ1interactor200FEZ (PF07763, IPR011680): FEZ-like protein
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
26 FGFR1oncoprotein31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
27 FGFR2oncoprotein200Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
28 GABARAPsuppressor31.0000Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
29 GOLGA7interactor100Erf4 (PF10256, IPR019383): Golgin subfamily A member 7/ERF4 family
30 GPM6Ainteractor30.6671.000Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
DUF2701 (PF10857, IPR022586): Protein of unknown function (DUF2701)
31 IFNGR1interactor21.0000IFNGR1 (PF07140, IPR021126): Interferon gamma receptor (IFNGR1)
Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
32 KDSRoncoprotein1007kD_coat (PF02495, IPR003411): 7kD viral coat protein
adh_short (PF00106, IPR002198): short chain dehydrogenase
33 LPAR1oncoprotein21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
34 LRP10interactor100CUB (PF00431, IPR000859, SM00042): CUB domain
Syndecan (PF01034, IPR027789): Syndecan domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
35 MAP1LC3B2interactor100Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
36 MRFAP1interactor100MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
37 NDFIP1interactor30.6671.000DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Comm (PF15957, IPR031878): Commissureless
38 NDFIP2interactor100DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
39 NOTCH3suppressor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
40 PGRMC1interactor21.0000Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
SlyX (PF04102, IPR007236): SlyX
SCNM1_acidic (PF15805, IPR031625): Acidic C-terminal region of sodium channel modifier 1 SCNM1
41 PI4K2Ainteractor21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
42 PTPMT1interactor50.6672.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
43 RDH14interactor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
44 RNF13interactor30.6671.000DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
45 RNF149interactor21.0000PA (PF02225, IPR003137): PA domain
UPF0233 (PF06781, IPR009619): Uncharacterised protein family (UPF0233)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
46 SDCBPinteractor30.6671.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
47 SNX17interactor100FERM_M (PF00373, IPR019748): FERM central domain
PX (PF00787, IPR001683, SM00312): PX domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
48 SPACA1interactor30.6671.000DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
49 STX6interactor100Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
50 TEX29interactor30.6671.000Connexin (PF00029, IPR013092, SM00037): Connexin
TEX29 (PF15839, IPR031685): Testis-expressed sequence 29 protein
51 TIMM17Ainteractor40.5002.667Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
52 TIMM17Binteractor21.0000Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
53 TIMM44interactor40.6671.667Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
RecG_N (PF17190): RecG N-terminal helical domain
54 TMOD2interactor100Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
Tropomodulin (PF03250, IPR004934): Tropomodulin
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
55 TMOD3interactor100Tropomodulin (PF03250, IPR004934): Tropomodulin
Usher (PF00577, IPR000015): Outer membrane usher protein
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
56 TNFRSF10Bsuppressor60.33310.000Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
57 UGCGinteractor21.0000Glyco_transf_21 (PF13506, IPR025993): Glycosyl transferase family 21
58 ZDHHC9interactor30.6671.000UPF0182 (PF03699, IPR005372): Uncharacterised protein family (UPF0182)
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
DUF4714 (PF15833, IPR031674): Domain of unknown function (DUF4714)

B a c k    t o    T o p ⇑

List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 C15orf48interactorB12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
2 C2orf47interactorTim44 (PF04280, IPR007379, SM00978): Tim44-like domain
3 NDUFA4interactorB12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
4 PAM16parental proteinPam16 (PF03656): Pam16
5 TSPAN3parental proteinHum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family

B a c k    t o    T o p ⇑