Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DA571172 is the fusion of parental proteins CMAS, SH3RF1 (from a repository: Wed Dec 7 16:42:33 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins8 (42.11 %)
The number (and %) of the tumor suppressors1 (5.26 %)
Total number of binary PPIs (saturation %)45 (26.32 %)
The number (and %) of affected PPIs18 (40.00 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.684
Assortativity coefficient-0.4540
The network average Clustering coefficient0.522
The number (and %) of a zero Clustering coefficients5 (26.32 %)
The number (and %) of a zero Betweenness Centrality10 (52.63 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SH3RF1,CMAS All fusions
: DA571172;
Proteins found in more fusions APP (see 4 fusions); SIAH2 (see 1 fusions); SIAH1 (see 4 fusions); RAC1 (see 1 fusions); UBE2N (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DA571172chimera180.111243.000zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
2 AKT1oncoprotein41.0000PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 AKT2oncoprotein21.0000PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 APPprotein found in more fusions80.33313.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 HERPUD1oncoprotein30.6671.000Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
6 KCNJ1interactor100IRK (PF01007, IPR016449): Inward rectifier potassium channel
7 MAP3K11interactor50.6671.667APG6 (PF04111, IPR007243): Autophagy protein Apg6
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
8 MAP4K3interactor100CNH (PF00780, IPR001180, SM00036): CNH domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
9 NINLinteractor100PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
10 PDCD6IPinteractor200BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
11 RAC1oncoprotein40.6670.667Ras (PF00071, IPR001806, SM00173): Ras family
12 SEMA6Ainteractor100PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
13 SH3RF2interactor40.5002.667SH3_2 (PF07653, IPR011511): Variant SH3 domain
TUDOR (PF00567, IPR002999, SM00333): Tudor domain
UPF0547 (PF10571, IPR018886): Uncharacterised protein family UPF0547
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
SH3_9 (PF14604, IPR001452): Variant SH3 domain
14 SIAH1suppressor70.4677.667Sina (PF03145, IPR018121): Seven in absentia protein family
15 SIAH2oncoprotein50.8330.667Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
16 UBE2D1interactor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
17 UBE2D3interactor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
18 UBE2Nprotein found in more fusions40.6671.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
19 YWHABinteractor21.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BRCA1suppressorBRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
2 CMASparental proteinCTP_transf_3 (PF02348, IPR003329): Cytidylyltransferase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
3 COG3interactorBaculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
OpuAC (PF04069, IPR007210): Substrate binding domain of ABC-type glycine betaine transport system
Sec34 (PF04136, IPR007265): Sec34-like family
Thioredoxin_6 (PF13848): Thioredoxin-like domain
4 DBNLinteractorRR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
5 DDB1interactorCPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
6 FBXO6interactorFBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
7 FGL1interactorFibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
8 FIG4interactorSyja_N (PF02383, IPR002013): SacI homology domain
9 HIST1H2BGoncoproteinHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
10 HIST1H3AinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
11 LIMS1interactorLIM (PF00412, IPR001781, SM00132): LIM domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
12 LUC7LinteractorLUC7 (PF03194, IPR004882): LUC7 N_terminus
Hid1 (PF12722): High-temperature-induced dauer-formation protein
13 NAA10oncoproteinAcetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
14 NAA15interactorNARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
15 SH3RF1parental proteinzf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain

B a c k    t o    T o p ⇑