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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DA305902 is the fusion of parental proteins WDR74, LAMP2 (from a repository: Tue Jan 10 23:24:37 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)47
The number (and %) of the onco-proteins13 (27.66 %)
The number (and %) of the tumor suppressors6 (12.77 %)
Total number of binary PPIs (saturation %)138 (12.77 %)
The number (and %) of affected PPIs46 (33.33 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI5.234
Assortativity coefficient-0.3633
The network average Clustering coefficient0.544
The number (and %) of a zero Clustering coefficients7 (14.89 %)
The number (and %) of a zero Betweenness Centrality17 (36.17 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: LINC00854,LAMP2 All fusions
: DA305902;
Proteins found in more fusions TUBG1 (see 1 fusions); APEH (see 1 fusions); EWSR1 (see 2 fusions); MCM7 (see 2 fusions); PCNA (see 1 fusions); TNF (see 1 fusions); LYN (see 2 fusions); PRPF19 (see 2 fusions); IBTK (see 2 fusions); NPM1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DA305902chimera460.0741647.500Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
2 APEHoncoprotein200Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
3 ATP6V1B1interactor31.0000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
4 BCAS2interactor50.7002.667BCAS2 (PF05700, IPR008409): Breast carcinoma amplified sequence 2 (BCAS2)
ZapB (PF06005, IPR009252): Cell division protein ZapB
5 CCNJLinteractor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
6 DDX21interactor60.5336.667CRT10 (PF08728, IPR014839): CRT10
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
GUCT (PF08152, IPR012562): GUCT (NUC152) domain
Sulfatase (PF00884, IPR000917): Sulfatase
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
7 DHX37interactor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1661 (PF07877, IPR012456): Protein of unknown function (DUF1661)
eIF3_subunit (PF08597, IPR013906): Translation initiation factor eIF3 subunit
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
8 ELAVL1oncoprotein140.21859.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9 EPRSinteractor30.6670.667GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
10 EWSR1oncoprotein80.4768.833RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
11 GNL2interactor31.0000DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
NGP1NT (PF08153, IPR012971): NGP1NT (NUC091) domain
SDA1 (PF05285, IPR007949): SDA1
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
12 HDAC11interactor100Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
13 HIF1Asuppressor30.6670.667Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
14 HNRNPUinteractor130.26950.167CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
15 HP1BP3interactor40.6672.000RXT2_N (PF08595, IPR013904): RXT2-like, N-terminal
SDA1 (PF05285, IPR007949): SDA1
YL1 (PF05764, IPR008895): YL1 nuclear protein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
16 IBTKprotein found in more fusions40.6670.667BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
17 IMPDH1interactor100IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
18 LYNoncoprotein50.6672.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
19 MCM7protein found in more fusions60.4005.667MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
20 MDM2oncoprotein100.27824.333Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
21 NCBP3interactor30.6671.000Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
TLP-20 (PF06088, IPR009092): Nucleopolyhedrovirus telokin-like protein-20 (TLP20)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
22 NCSTNinteractor80.46412.500Nicastrin (PF05450, IPR008710): Nicastrin
Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
23 NPM1suppressor100.38917.500Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
24 PCNAoncoprotein70.3339.000PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
25 PDS5Bsuppressor21.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
HEAT (PF02985, IPR000357): HEAT repeat
Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein
RNA_pol_Rpo13 (PF12136, IPR021985): RNA polymerase Rpo13 subunit HTH domain
DUF3665 (PF12427, IPR024614): Branched-chain amino acid aminotransferase
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
26 PIAS4interactor21.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
27 PKN2interactor40.6670.667C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
28 PRPF19protein found in more fusions70.7332.833Prp19 (PF08606, IPR013915): Prp19/Pso4-like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
29 PXKinteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
PX (PF00787, IPR001683, SM00312): PX domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
MNR (PF15718, IPR031447): Protein moonraker
30 RBBP4oncoprotein40.5002.667eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
31 RCHY1suppressor31.0000C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
32 RFC1interactor40.5002.333AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
Nexin_C (PF08628, IPR013937): Sorting nexin C terminal
RFC1 (PF08519, IPR013725): Replication factor RFC1 C terminal domain
DUF2316 (PF10078, IPR018757): Uncharacterized protein conserved in bacteria (DUF2316)
33 RNF13interactor100DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
34 RRS1interactor50.8001.167GRP (PF07172, IPR010800): Glycine rich protein family
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RRS1 (PF04939, IPR007023): Ribosome biogenesis regulatory protein (RRS1)
35 SAFBsuppressor60.6004.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
36 SF3B3interactor70.5718.167CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
37 SF3B6interactor70.5248.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
38 SNRPA1interactor80.39315.667LRR_9 (PF14580): Leucine-rich repeat
39 SRP14interactor31.0000SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
40 SSBinteractor40.6672.000HMA (PF00403, IPR006121): Heavy-metal-associated domain
La (PF05383, IPR006630, SM00715): La domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_3 (PF08777, IPR014886): RNA binding motif
41 SUB1interactor31.0000Dehydrin (PF00257, IPR000167): Dehydrin
PC4 (PF02229, IPR003173): Transcriptional Coactivator p15 (PC4)
42 THOC6interactor40.5002.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
43 TNFoncoprotein41.0000TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
44 TUBA1Binteractor21.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
45 TUBBinteractor70.33313.333Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
46 TUBG1protein found in more fusions40.6670.667Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
47 UCHL1suppressor21.0000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BOP1oncoproteinBOP1NT (PF08145, IPR012953, SM01035): BOP1NT (NUC169) domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3038 (PF11237, IPR021399): Protein of unknown function (DUF3038)
Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
2 CARD8oncoproteinCARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
FIIND (PF13553, IPR025307): Function to find
3 DDX39BinteractorDEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
4 DDX47interactorDEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
5 HSPA8oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
6 IFI16suppressorHIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
7 LAMP2parental proteinLamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
8 LGALS3oncoproteinGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
9 METTL21BinteractorMethyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
10 NOP56interactorCytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
11 NSUN2interactorMethyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
12 NUDT3interactorNUDIX (PF00293, IPR000086): NUDIX domain
13 PDGFRAoncoproteinHerpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
LAT (PF15234, IPR008359): Linker for activation of T-cells
14 PPIP5K2interactorHis_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
RimK (PF08443, IPR013651): RimK-like ATP-grasp domain
15 PUS7interactorR3H (PF01424, IPR001374, SM00393): R3H domain
TruD (PF01142, IPR001656): tRNA pseudouridine synthase D (TruD)
16 RGS2oncoproteinRGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
17 SNCAinteractorSynuclein (PF01387, IPR001058): Synuclein
18 THOC5oncoproteinFimP (PF09766, IPR019163): Fms-interacting protein
19 UBE3CinteractorIQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
20 USP7oncoproteinMATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
21 VAT1interactorADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
22 WBSCR22interactorMethyltransf_11 (PF08241, IPR013216): Methyltransferase domain
WBS_methylT (PF12589, IPR022238): Methyltransferase involved in Williams-Beuren syndrome
23 WDR74parental proteinWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
24 XPO1interactorCRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
25 ZC3H15interactorzf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Torus (PF16131, IPR032297): Torus domain
DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46

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