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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: DA290461 is the fusion of parental proteins NDUFS4, RTN3 (from a repository: Thu Apr 13 18:42:18 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins2 (9.52 %)
The number (and %) of the tumor suppressors2 (9.52 %)
Total number of binary PPIs (saturation %)38 (18.10 %)
The number (and %) of affected PPIs20 (52.63 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.048
Assortativity coefficient-0.2790
The network average Clustering coefficient0.473
The number (and %) of a zero Clustering coefficients8 (38.10 %)
The number (and %) of a zero Betweenness Centrality15 (71.43 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: NDUFS4,RTN3 All fusions
: DA290461;
Proteins found in more fusions SNX1 (see 1 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DA290461chimera200.063317.333Reticulon (PF02453, IPR003388): Reticulon
2 ATL3interactor21.0000GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
3 ATP1B3interactor30.6670.667Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
4 CDIPTinteractor100A2M_N (PF01835, IPR002890): MG2 domain
Dynactin (PF12455, IPR022157): Dynein associated protein
5 COL4A3BPinteractor31.0000Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
PH (PF00169, IPR001849, SM00233): PH domain
START (PF01852, IPR002913, SM00234): START domain
6 FAM160A2interactor100RAI16-like (PF10257, IPR019384): Retinoic acid induced 16-like protein
7 FXR2interactor31.0000Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
8 PLEKHF2interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
9 PPP2R3Cinteractor100DUF61 (PF01886, IPR002746): Protein of unknown function DUF61
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
10 PRTFDC1interactor100Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
11 PTPN9interactor100CRAL_TRIO_N (PF03765, IPR011074, SM01100): CRAL/TRIO, N-terminal domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
12 RTN4suppressor110.20035.667CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
13 SNX1protein found in more fusions31.0000PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
14 SPOPsuppressor31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
MATH (PF00917, IPR002083, SM00061): MATH domain
15 TCTN2interactor30.6670.667DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
16 TCTN3interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
17 TERF1interactor40.6671.000TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
18 UGCGinteractor100Glyco_transf_21 (PF13506, IPR025993): Glycosyl transferase family 21
19 VAPAinteractor30.6670.667DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
20 XPO1interactor21.0000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
21 ZNF391interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ABCD3interactorABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
2 ALDOAinteractorGlycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
3 ALDOCinteractorGlycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
4 APPinteractorAPP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATAD3AinteractorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
6 ATP1A1interactorCation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
7 ATP2A2interactorCation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
8 ATP5A1interactorATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
9 ATP5C1interactorATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
10 ATP5F1interactorMt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
11 ATP5OinteractorOSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
12 ATP6V0D1interactorvATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
13 CACNA2D1interactordCache_1 (PF02743, IPR004010): Cache domain
VGCC_alpha2 (PF08473, IPR013680): Neuronal voltage-dependent calcium channel alpha 2acd
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWA_N (PF08399, IPR013608): VWA N-terminal
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
14 COX15interactorCOX15-CtaA (PF02628, IPR003780): Cytochrome oxidase assembly protein
Peptidase_S3 (PF00944, IPR000930): Alphavirus core protein
15 COX4I1interactorCOX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
16 COX6B1interactorCOX6B (PF02297, IPR003213): Cytochrome oxidase c subunit VIb
17 COX7A2LinteractorCOX7a (PF02238, IPR003177): Cytochrome c oxidase subunit VII
18 CYC1interactorCytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
19 DLATinteractor2-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
Stm1_N (PF09598, IPR019084): Stm1
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
20 DNAJC30interactorDnaJ (PF00226, IPR001623, SM00271): DnaJ domain
21 FUBP1oncoproteinDUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
22 FUBP3interactorDUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
23 GOLT1BinteractorGot1 (PF04178, IPR007305): Got1/Sft2-like family
24 M6PRinteractorMan-6-P_recep (PF02157, IPR028927): Mannose-6-phosphate receptor
25 MARC1interactorMOSC (PF03473, IPR005302): MOSC domain
MOSC_N (PF03476, IPR005303): MOSC N-terminal beta barrel domain
26 MGST3interactorMAPEG (PF01124, IPR001129): MAPEG family
27 MRPL15interactorRibosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
28 MT-ND5interactorNADH5_C (PF06455, IPR010934): NADH dehydrogenase subunit 5 C-terminus
Proton_antipo_M (PF00361, IPR001750): Proton-conducting membrane transporter
Proton_antipo_N (PF00662, IPR001516): NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
29 ND1interactorNA
30 ND4interactorNA
31 NDUFA11interactor7kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
32 NDUFA12interactorNDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
33 NDUFA13interactorGRIM-19 (PF06212, IPR009346): GRIM-19 protein
34 NDUFA2interactorL51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
35 NDUFA4interactorB12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
36 NDUFA7interactorCI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
37 NDUFA8interactorCHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
38 NDUFA9interactorEpimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
39 NDUFAF3interactorDUF498 (PF04430, IPR007523): Protein of unknown function (DUF498/DUF598)
40 NDUFB10interactorNDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
41 NDUFB4interactorNDUF_B4 (PF07225, IPR009866): NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
42 NDUFB5interactorNDUF_B5 (PF09781, IPR019173): NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
43 NDUFB8interactorNDUF_B8 (PF05821, IPR008699): NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
44 NDUFS1interactorNADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase
NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
45 NDUFS2interactorComplex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
46 NDUFS3interactorComplex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
47 NDUFS4parental proteinETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
48 NDUFS5interactorNdufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
49 NDUFS6interactorThiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
50 NDUFS7interactorOxidored_q6 (PF01058, IPR006137): NADH ubiquinone oxidoreductase, 20 Kd subunit
51 NDUFS8interactorFer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
Fer4_16 (PF13484): 4Fe-4S double cluster binding domain
52 NDUFV1interactorComplex1_51K (PF01512, IPR011538): Respiratory-chain NADH dehydrogenase 51 Kd subunit
NADH_4Fe-4S (PF10589, IPR019575, SM00928): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
SLBB (PF10531, IPR019554): SLBB domain
53 NDUFV2interactor2Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
54 NDUFV3interactorDUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NDUFV3 (PF15880, IPR026193): NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
55 NUP188interactorNup188 (PF10487, IPR018864): Nucleoporin subcomplex protein binding to Pom34
Nup192 (PF11894, IPR021827): Nuclear pore complex scaffold, nucleoporins 186/192/205
56 OGDHinteractorE1_dh (PF00676, IPR001017): Dehydrogenase E1 component
Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
2-oxogl_dehyd_N (PF16078, IPR032106): 2-oxoglutarate dehydrogenase N-terminus
OxoGdeHyase_C (PF16870, IPR031717): 2-oxoglutarate dehydrogenase C-terminal
57 PARK2suppressorIBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
58 PRPHinteractorFilament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
59 PRRT2interactorCD225 (PF04505, IPR007593): Interferon-induced transmembrane protein
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
60 RAB33AoncoproteinRas (PF00071, IPR001806, SM00173): Ras family
61 RPL14interactorKOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
62 RPL23interactorRibosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
63 RPS14interactorRibosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
64 RPS2interactorRibosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
65 RTN3parental proteinReticulon (PF02453, IPR003388): Reticulon
66 SDHBsuppressorFer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
67 SLC25A5interactorMito_carr (PF00153, IPR018108): Mitochondrial carrier protein
68 TOMM20interactorRSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
69 UBE2G2interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
70 UQCRBinteractorUCR_14kD (PF02271, IPR003197): Ubiquinol-cytochrome C reductase complex 14kD subunit
71 UQCRC2oncoproteinPeptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
72 UQCRHinteractorHerpes_pp85 (PF04637, IPR006731): Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
73 VDAC1interactorPorin_3 (PF01459, IPR027246): Eukaryotic porin
74 VDAC2interactorPorin_3 (PF01459, IPR027246): Eukaryotic porin
75 VDAC3interactorPorin_3 (PF01459, IPR027246): Eukaryotic porin

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