Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DA246675 is the fusion of parental proteins NPM2, CDC16 (from a repository: Fri Jul 19 11:03:58 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins11 (33.33 %)
The number (and %) of the tumor suppressors7 (21.21 %)
Total number of binary PPIs (saturation %)167 (31.63 %)
The number (and %) of affected PPIs32 (19.16 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI9.030
Assortativity coefficient-0.2573
The network average Clustering coefficient0.611
The number (and %) of a zero Clustering coefficients2 (6.06 %)
The number (and %) of a zero Betweenness Centrality7 (21.21 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CDC16,NPM2 All fusions
: DA246675;
Proteins found in more fusions CREBBP (see 6 fusions); TAF4 (see 4 fusions); SDCBP2 (see 1 fusions); EP300 (see 1 fusions); SRPK2 (see 1 fusions); TRIM33 (see 1 fusions); SMAD3 (see 3 fusions); NPM1 (see 1 fusions); NAP1L4 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DA246675chimera320.236468.207Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
2 ANAPC10interactor120.53017.267ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
3 ANAPC2interactor130.6799.148ANAPC2 (PF08672, IPR014786, SM01013): Anaphase promoting complex (APC) subunit 2
Cullin (PF00888, IPR001373, SM00182): Cullin family
4 ANAPC5interactor120.7584.862TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
5 ANAPC7interactor160.61016.388TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_21 (PF09976, IPR018704): Tetratricopeptide repeat-like domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
6 BRCA1suppressor80.6195.233BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
7 CDC20oncoprotein160.58122.655WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
8 CDC23interactor170.51734.160ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
9 CDC27oncoprotein190.47742.836TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
10 COPS2suppressor50.6002.833YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
11 CREBBPsuppressor120.60011.052Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
12 DNAJA1interactor40.6671.333DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
13 EP300oncoprotein150.45127.888Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
14 FZR1suppressor120.7127.790WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
15 KRASoncoprotein60.5003.500Ras (PF00071, IPR001806, SM00173): Ras family
16 MOV10interactor50.5004.000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
17 NAP1L4protein found in more fusions110.51112.971NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
18 NEK2interactor61.0000Pkinase (PF00069, IPR000719): Protein kinase domain
19 NPM1suppressor120.34530.667Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
20 NPM3interactor21.0000Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
21 NXF1interactor70.4676.333NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
22 PAXIP1interactor90.6398.105BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
23 PHF8interactor81.0000JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
PHD (PF00628, IPR019787, SM00249): PHD-finger
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
24 PLEKHF2interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
25 RB1suppressor70.6195.200RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
26 SDCBP2protein found in more fusions200PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
27 SMAD2suppressor100.6393.879MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
28 SMAD3oncoprotein90.6434.640MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
29 SMCR8interactor100Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
30 SRPK2oncoprotein31.0000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
31 TAF3interactor60.7332.167Bromo_TP (PF07524, IPR006565): Bromodomain associated
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
FHIPEP (PF00771, IPR001712): FHIPEP family
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
32 TAF4protein found in more fusions70.8001.300TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
33 TRIM33oncoprotein100.7223.586PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
Spectrin (PF00435, IPR002017): Spectrin repeat
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ANAPC1suppressorPC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
ANAPC1 (PF12859, IPR024990): Anaphase-promoting complex subunit 1
2 ANAPC11interactorzf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
3 ANAPC13interactorApc13p (PF05839, IPR008401): Apc13p protein
4 ANAPC15interactorNa_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
5 ANAPC16interactorDUF2110 (PF09883, IPR016757): Uncharacterized protein conserved in archaea (DUF2110)
6 ANAPC4interactorANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
ANAPC4 (PF12896, IPR024790): Anaphase-promoting complex, cyclosome, subunit 4
7 ATP5JinteractorATP-synt_F6 (PF05511, IPR008387): Mitochondrial ATP synthase coupling factor 6
8 B4GALT7interactorGlyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase
Glyco_transf_7N (PF13733, IPR027995): N-terminal region of glycosyl transferase group 7
9 BUB1BoncoproteinMad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
10 C11orf49interactorNA
11 CCNB1oncoproteinAdeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
12 CDC16parental proteinDynein_light (PF01221, IPR001372): Dynein light chain type 1
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
13 CDC26interactorANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
14 CDC5LinteractorOmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
15 CFAP97interactorDUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
KIAA1430 (PF13879, IPR029488): KIAA1430 homologue
GH97_C (PF14509, IPR029483): Glycosyl-hydrolase 97 C-terminal, oligomerisation
16 DAB2suppressorPID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
17 FBXO5oncoproteinIBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
18 FTH1interactorCoat_F (PF07875, IPR012851): Coat F domain
Ferritin (PF00210, IPR008331): Ferritin-like domain
19 HECW2interactorC2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
20 HINT1suppressorHIT (PF01230, IPR001310): HIT domain
21 MAD2L1oncoproteinHORMA (PF02301, IPR003511): HORMA domain
22 MAGIXinteractorPDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
23 MDC1suppressorFHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
24 NPM2parental proteinNucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
25 NSUN5interactorMethyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
BrnA_antitoxin (PF14384, IPR025528): BrnA antitoxin of type II toxin-antitoxin system
26 PYCR1interactorApbA (PF02558, IPR013332): Ketopantoate reductase PanE/ApbA
F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
P5CR_dimer (PF14748, IPR029036): Pyrroline-5-carboxylate reductase dimerisation
27 PYCR2interactorApbA (PF02558, IPR013332): Ketopantoate reductase PanE/ApbA
F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
P5CR_dimer (PF14748, IPR029036): Pyrroline-5-carboxylate reductase dimerisation
28 SH3KBP1interactorTmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
29 SMARCAD1interactorCUE (PF02845, IPR003892, SM00546): CUE domain
Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
30 TAF5interactorHerpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Late_protein_L2 (PF00513, IPR000784): Late Protein L2
TFIID_NTD2 (PF04494, IPR007582): WD40 associated region in TFIID subunit, NTD2 domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31 TP53BP1suppressor53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
32 TTKinteractorMad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
T3SS_basalb_I (PF17001, IPR012670): Type III secretion basal body protein I, YscI, HrpB, PscI
Mad3_BUB1_I_2 (PF17014, IPR031522): Putative Mad3/BUB1 like region 1 protein
33 TTLL1interactorTTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
34 UBE2SinteractorALF (PF03752, IPR005506): Short repeats of unknown function
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
35 USP37interactorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
UCH_N (PF16674, IPR032069): N-terminal of ubiquitin carboxyl-terminal hydrolase 37
36 XRCC5suppressorKu (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like

B a c k    t o    T o p ⇑