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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: DA142897 is the fusion of parental proteins AGT, GABBR2 (from a repository: Tue Mar 14 04:49:33 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)6
The number (and %) of the onco-proteins4 (66.67 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)9 (60.00 %)
The number (and %) of affected PPIs5 (55.56 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.4472
The network average Clustering coefficient0.350
The number (and %) of a zero Clustering coefficients3 (50.00 %)
The number (and %) of a zero Betweenness Centrality5 (83.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: AGT,GABBR2 All fusions
: DA142897;
Proteins found in more fusions GRB2 (see 1 fusions); ITSN2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DA142897chimera50.10018.0007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
2 ATF4oncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
3 GABBR1interactor21.00007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
DUF1700 (PF08006, IPR012963): Protein of unknown function (DUF1700)
NEMP (PF10225, IPR019358): NEMP family
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
4 GLP1Rinteractor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
5 GRB2oncoprotein200SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
6 ITSN2protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACEinteractorPeptidase_M2 (PF01401, IPR001548): Angiotensin-converting enzyme
2 ACE2interactorPeptidase_M2 (PF01401, IPR001548): Angiotensin-converting enzyme
Collectrin (PF16959, IPR031588): Renal amino acid transporter
3 AGTparental proteinNuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
4 ATP6AP2interactorPhosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
5 ECE1interactorPeptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
6 EWSR1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
7 GABBR2parental protein7tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
8 GSDMBinteractorGasdermin (PF04598, IPR007677): Gasdermin family
9 KCTD12interactorBTB_2 (PF02214, IPR003131): BTB/POZ domain
10 MMEsuppressorPeptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
11 RENinteractorA1_Propeptide (PF07966, IPR012848): A1 Propeptide
Asp (PF00026, IPR001461): Eukaryotic aspartyl protease
12 SH3GL3interactorBAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
13 TP53suppressorDEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif

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