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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: CX755976 is the fusion of parental proteins NMT1, CLN8 (from a repository: Tue Feb 14 21:23:21 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins4 (16.67 %)
The number (and %) of the tumor suppressors3 (12.50 %)
Total number of binary PPIs (saturation %)33 (11.96 %)
The number (and %) of affected PPIs23 (69.70 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.417
Assortativity coefficient-0.4770
The network average Clustering coefficient0.320
The number (and %) of a zero Clustering coefficients15 (62.50 %)
The number (and %) of a zero Betweenness Centrality22 (91.67 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions
PPI for parental proteins: NMT1,CLN8 All fusions
: CX755976;
Proteins found in more fusions UBC (see 1 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam, InterPro, SMART): description
1 CX755976chimera230.024493.000TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
2 ARL6IP5suppressor21.0000PRA1 (PF03208, IPR004895): PRA1 family protein
RBD-FIP (PF09457, IPR019018): FIP domain
3 BNIP3oncoprotein41.0000BNIP3 (PF06553, IPR010548): BNIP3
4 BNIP3Lsuppressor41.0000BNIP3 (PF06553, IPR010548): BNIP3
5 C14orf1interactor100Erg28 (PF03694, IPR005352): Erg28 like protein
6 CD9oncoprotein100Tetraspannin (PF00335, IPR018499): Tetraspanin family
7 CYB5Binteractor100Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIP (PF00230, IPR000425): Major intrinsic protein
8 GPM6Binteractor100PspB (PF06667, IPR009554): Phage shock protein B
Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
9 MTX1interactor100Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
10 PDIA6interactor100FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
11 PLP1interactor21.0000Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
12 PTPRNinteractor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
Receptor_IA-2 (PF11548, IPR021613): Protein-tyrosine phosphatase receptor IA-2
RESP18 (PF14948, IPR029403): RESP18 domain
13 RTN4suppressor40.6671.000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
14 SPCS2interactor100SPC25 (PF06703, IPR009582): Microsomal signal peptidase 25 kDa subunit (SPC25)
15 STX8interactor100CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
SNARE (PF05739, IPR000727, SM00397): SNARE domain
HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain
16 TMEM107interactor100TMEM107 (PF14995, IPR029248): Transmembrane protein
17 TMEM11interactor31.0000Mito_morph_reg (PF14972, IPR026120): Mitochondrial morphogenesis regulator
18 TMEM134interactor100CD99L2 (PF12301, IPR022078): CD99 antigen like protein 2
19 TMEM147interactor100DUF2053 (PF09767, IPR019164): Predicted membrane protein (DUF2053)
20 TMEM14Ainteractor100Tmemb_14 (PF03647, IPR005349): Transmembrane proteins 14C
21 TUBB4Ainteractor100Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
22 UBCprotein found in more fusions200ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
23 VAPAinteractor21.0000DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
24 ZUFSPinteractor100zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Peptidase_C78 (PF07910, IPR012462): Peptidase family C78
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ABCF1interactorABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
ABC_tran_Xtn (PF12848, IPR032781): ABC transporter
AAA_18 (PF13238): AAA domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
2 ABLIM1interactorLIM (PF00412, IPR001781, SM00132): LIM domain
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
3 ACSL4interactorAMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
4 AHI1oncoproteinArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
5 C14orf166interactorRLL (PF10036, IPR019265): Putative carnitine deficiency-associated protein
6 CABP1interactorDUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7 CABP2interactorEF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8 CAPN1interactorCalpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
9 CDCA3interactorNA
10 CEP19interactorCEP19 (PF14933, IPR029412): CEP19-like protein
11 CEP89interactorATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
12 CLN8parental proteinTRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
13 CSNK2A1oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
14 DCTN1interactorBap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
15 DDX1oncoproteinDEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
16 DHX9oncoproteinDEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
17 DIMT1interactorRrnaAD (PF00398, IPR001737, SM00650): Ribosomal RNA adenine dimethylase
18 DTNAinteractorATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CRISPR_Cse2 (PF09485, IPR013382): CRISPR-associated protein Cse2 (CRISPR_cse2)
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
19 DYNC1LI2interactorDLIC (PF05783, IPR022780): Dynein light intermediate chain (DLIC)
20 EDC4interactorDUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
21 EID3interactorNse4_C (PF08743, IPR014854): Nse4 C-terminal
Nse4-Nse3_bdg (PF15412, IPR029225): Binding domain of Nse4/EID3 to Nse3-MAGE
22 EIF2B2interactorIF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
23 EIF2B3interactorNTP_transferase (PF00483, IPR005835): Nucleotidyl transferase
NAGPA (PF09992, IPR018711): Phosphodiester glycosidase
DUF4954 (PF16314, IPR032533): Domain of unknown function (DUF4954)
24 FAM84BinteractorLRAT (PF04970, IPR007053): Lecithin retinol acyltransferase
25 FBF1interactorDUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
26 FBXO17interactorFBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
27 FBXW7suppressorMem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
28 FKBP3interactorFKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
29 FLIIoncoproteinGelsolin (PF00626, IPR007123): Gelsolin repeat
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
30 FYNoncoproteinPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
31 GABARAPL2interactorAtg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
32 HNRNPMinteractorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M
Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
33 HNRNPUinteractorCDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
34 IARSinteractorAnticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
35 IGF2BP3interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
36 ILF2interactorDZF (PF07528, IPR006561, SM00572): DZF domain
37 LYNoncoproteinPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
38 MAP2oncoproteinMAP2_projctn (PF08377, IPR013588): MAP2/Tau projection domain
Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
RII_binding_1 (PF10522, IPR018459): RII binding domain
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
39 MARSoncoproteinAnticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1g (PF09334, IPR015413): tRNA synthetases class I (M)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain
40 MCM2oncoproteinAAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
41 MRE11AoncoproteinAPG6 (PF04111, IPR007243): Autophagy protein Apg6
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
42 NDRG2suppressorNdr (PF03096, IPR004142): Ndr family
43 NELFBinteractorCOBRA1 (PF06209, IPR010405): Cofactor of BRCA1 (COBRA1)
44 NMT1parental proteinNMT (PF01233, IPR022676): Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
NMT_C (PF02799, IPR022677): Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
45 NOP56interactorCytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
46 NTRK1oncoproteinI-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
47 NXF1interactorNTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
48 ODF3L2interactorSHIPPO-rpt (PF07004, IPR010736): Sperm-tail PG-rich repeat
49 PA2G4interactorPeptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
50 PDCD6oncoproteinEF-hand_7 (PF13499, IPR011992): EF-hand domain pair
51 PLCXD1interactorPI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
ShK (PF01549, IPR003582, SM00254): ShK domain-like
52 PLP2interactorMARVEL (PF01284, IPR008253): Membrane-associating domain
53 POLR1CinteractorRNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
54 QARSinteractortRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA_synt_1c_R1 (PF04558, IPR007639): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
55 RFC4interactorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
56 RP2interactorNDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
TBCC (PF07986, IPR012945): Tubulin binding cofactor C
57 RPL19interactorDUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e
58 RPL23AinteractorRibosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
59 RPL38interactorRibosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
60 RRP15interactorRrp15p (PF07890, IPR012459): Rrp15p
61 RTCBinteractorRtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
62 SCLT1oncoproteinDUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
63 SELENOKinteractorSelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
64 STILoncoproteinSTIL_N (PF15253, IPR026123): SCL-interrupting locus protein N-terminus
65 TGFB1suppressorTGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
66 TMEM128interactorNA
67 TP53suppressorDEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
68 VIMsuppressorFilament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
69 YBX1oncoproteinCSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
70 YBX3interactorCSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
71 YIPF6interactorYip1 (PF04893, IPR006977): Yip1 domain
72 ZNRF1interactorzf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
RNF220 (PF15926, IPR031824): E3 ubiquitin-protein ligase RNF220

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