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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: CT004483 is the fusion of parental proteins CXCR4, TSC22D3 (from a repository: Sun Jan 29 21:28:48 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins9 (32.14 %)
The number (and %) of the tumor suppressors7 (25.00 %)
Total number of binary PPIs (saturation %)85 (22.49 %)
The number (and %) of affected PPIs27 (31.76 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI4.714
Assortativity coefficient-0.3863
The network average Clustering coefficient0.590
The number (and %) of a zero Clustering coefficients7 (25.00 %)
The number (and %) of a zero Betweenness Centrality17 (60.71 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: TSC22D3,CXCR4 All fusions
: CT004483;
Proteins found in more fusions FOS (see 4 fusions); NEDD4L (see 3 fusions); MYOD1 (see 1 fusions); MAD1L1 (see 3 fusions); TP53 (see 3 fusions); NFKB1 (see 2 fusions); SGK1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CT004483chimera270.111551.567TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
2 C19orf57interactor200DUF4671 (PF15710, IPR031441): Domain of unknown function (DUF4671)
3 CASP8suppressor31.0000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
4 DCLK2interactor100DCX (PF03607, IPR003533, SM00537): Doublecortin
Metallothio_Pro (PF02069, IPR000518): Prokaryotic metallothionein
Pkinase (PF00069, IPR000719): Protein kinase domain
5 EID3interactor31.0000Nse4_C (PF08743, IPR014854): Nse4 C-terminal
Nse4-Nse3_bdg (PF15412, IPR029225): Binding domain of Nse4/EID3 to Nse3-MAGE
6 FIGNL1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
7 FOSoncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
8 HDAC1suppressor120.38229.667FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
9 HDAC2suppressor70.6673.333Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
10 HPCAL4interactor100EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
11 ITCHinteractor60.6003.333C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
12 JUNoncoprotein90.5369.233bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
13 MAD1L1suppressor41.0000MAD (PF05557, IPR008672): Mitotic checkpoint protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
14 MDM2oncoprotein80.7622.233Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
15 MTA2interactor41.0000BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
16 MYOD1oncoprotein41.0000Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Mfp-3 (PF04202, IPR007328): Foot protein 3
Myf5 (PF12232, IPR022032): Myogenic determination factor 5
17 NEDD4Lsuppressor51.0000WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
18 NFKB1suppressor50.6672.000Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
19 NFKB2oncoprotein31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Death (PF00531, IPR000488, SM00005): Death domain
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
20 PCK1interactor100PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
21 PLEKHF2interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
22 RAF1oncoprotein51.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
23 SCNN1Boncoprotein50.7003.000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
24 SGK1oncoprotein51.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
25 SUMO1interactor60.9000.333Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
26 TP53suppressor100.47215.567DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
27 TSC22D4interactor100AflR (PF08493, IPR013700): Aflatoxin regulatory protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
28 UBE2Iinteractor80.7143.733UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ALDH3B1interactorAldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
2 ATP13A2interactorE1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
MARVEL (PF01284, IPR008253): Membrane-associating domain
P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter
3 B2MoncoproteinC1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
4 CAV1suppressorCaveolin (PF01146, IPR001612): Caveolin
5 CCR5interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6 CD4suppressorATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family
C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
CD4-extracel (PF09191, IPR015274): CD4, extracellular
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
7 CXCL12suppressorIL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
8 CXCR4parental protein7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal
9 CXCR5interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
10 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 ENDOVinteractorEndonuclease_5 (PF04493, IPR007581): Endonuclease V
12 GNA13interactorG-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
13 GOLT1BinteractorGot1 (PF04178, IPR007305): Got1/Sft2-like family
14 GRK3interactorPH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
15 HLA-BoncoproteinMHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
16 JAK2oncoproteinFERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
17 JAK3oncoproteinPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
18 MYBL2oncoproteinCmyb_C (PF09316, IPR015395): C-myb, C-terminal
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
19 P4HBinteractorGlycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
20 PTK2interactorFERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
21 PTPN11suppressorSH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
22 PTPN6suppressorSH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
23 SOCS3suppressorSH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
24 ST13suppressorHox9_act (PF04617, IPR006711): Hox9 activation region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
25 STAMinteractorGAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
26 TMEM63BinteractorRSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
27 TSC22D3parental proteinTSC22 (PF01166, IPR000580): TSC-22/dip/bun family
28 UBCinteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
29 USP14interactorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

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