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Powered by Cytoscape Web for: CF138660 is the fusion of parental proteins WWC3, TRPS1 (from a repository: Fri Jan 13 04:04:19 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins6 (46.15 %)
The number (and %) of the tumor suppressors3 (23.08 %)
Total number of binary PPIs (saturation %)33 (42.31 %)
The number (and %) of affected PPIs12 (36.36 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI4.154
Assortativity coefficient-0.5160
The network average Clustering coefficient0.653
The number (and %) of a zero Clustering coefficients2 (15.38 %)
The number (and %) of a zero Betweenness Centrality7 (53.85 %)


List of the fusions

PPI for parental proteins: WWC3,TRPS1 All fusions
: CF138660;
Proteins found in more fusions APP (see 4 fusions); WWC2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CF138660chimera120.22782.667APG6 (PF04111, IPR007243): Autophagy protein Apg6
DivIC (PF04977, IPR007060): Septum formation initiator
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
DUF4452 (PF14618, IPR027915): Domain of unknown function (DUF4452)
LURAP (PF14854): Leucine rich adaptor protein
2 APPprotein found in more fusions40.6671.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 CDK18oncoprotein21.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
4 DLC1suppressor31.0000RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
START (PF01852, IPR002913, SM00234): START domain
DUF4561 (PF15120, IPR027818): Domain of unknown function (DUF4561)
5 DYNLL1interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
6 LATS1suppressor60.6005.333Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
7 LATS2suppressor60.8001.333Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
8 MAPK3oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
9 NFATC1oncoprotein100RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
10 PRKCAinteractor41.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
11 SEC16Ainteractor31.0000APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
12 WWC1interactor70.5248.333APG6 (PF04111, IPR007243): Autophagy protein Apg6
bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
WW (PF00397, IPR001202, SM00456): WW domain
13 WWC2protein found in more fusions70.6673.333DASH_Dad2 (PF08654, IPR013963): DASH complex subunit Dad2
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Phage_Nu1 (PF07471, IPR010906): Phage DNA packaging protein Nu1
WW (PF00397, IPR001202, SM00456): WW domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CDK2AP1suppressorCDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
2 CEP170P1interactorNA
3 CTBP1interactor2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
4 FOXJ2interactorSARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
5 HDAC1suppressorFSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
6 MCM6interactorMCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
7 NLKinteractorPkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
8 RNF4interactorSgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
9 SUMO1interactorRad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
10 TEAD2interactorTEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
11 TP53BP1suppressor53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
12 TRPS1parental proteinRubredoxin (PF00301, IPR024935): Rubredoxin
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
13 UBE2IinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
14 WWC3parental proteinAPG6 (PF04111, IPR007243): Autophagy protein Apg6
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
IncA (PF04156, IPR007285): IncA protein
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
MDMPI_N (PF11716, IPR024344): Mycothiol maleylpyruvate isomerase N-terminal domain
DUF4452 (PF14618, IPR027915): Domain of unknown function (DUF4452)
LURAP (PF14854): Leucine rich adaptor protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease

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