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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: CF137274 is the fusion of parental proteins CCNF (from a repository: Thu May 28 01:57:45 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins7 (53.85 %)
The number (and %) of the tumor suppressors2 (15.38 %)
Total number of binary PPIs (saturation %)27 (34.62 %)
The number (and %) of affected PPIs12 (44.44 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.538
Assortativity coefficient-0.5352
The network average Clustering coefficient0.528
The number (and %) of a zero Clustering coefficients4 (30.77 %)
The number (and %) of a zero Betweenness Centrality7 (53.85 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CCNF,LOC105371050 All fusions
: CF137274;
Proteins found in more fusions CUL1 (see 3 fusions); MYBL2 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CF137274chimera120.167100.333Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
F-box (PF00646, IPR001810, SM00256): F-box domain
2 CCNB1oncoprotein40.8330.667Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
3 CCP110interactor21.0000DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
CALM_bind (PF16025): Calcium-dependent calmodulin binding
4 CDC6oncoprotein31.0000Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
5 CDK1oncoprotein60.6003.667Pkinase (PF00069, IPR000719): Protein kinase domain
6 CUL1suppressor50.8330.667Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
7 MYBL2oncoprotein200Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
8 NUSAP1interactor100GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
9 PSMA6interactor50.6004.000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
10 RBX1oncoprotein50.8330.667zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
11 RRM2interactor100Ribonuc_red_sm (PF00268, IPR000358): Ribonucleotide reductase, small chain
12 SCYL1suppressor100HEAT (PF02985, IPR000357): HEAT repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
13 SKP1oncoprotein31.0000Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CCNFparental proteinCyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
F-box (PF00646, IPR001810, SM00256): F-box domain

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