Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	160
The number (and %) of the onco-proteins	44 (27.50 %)
The number (and %) of the tumor suppressors	19 (11.88 %)
Total number of binary PPIs (saturation %)	4959 (38.99 %)
The number (and %) of affected PPIs	159 (3.21 %)
The number of possible different fusions	33
PPI diameter	2
PPI radius	1
The average degree of PPI	61.500
Assortativity coefficient	-0.0954
The network average Clustering coefficient	0.693
The number (and %) of a zero Clustering coefficients	0 (0.00 %)
The number (and %) of a zero Betweenness Centrality	5 (3.12 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: HIST1H1C,ZNF90	All fusions : CF128699;
Proteins found in more fusions	EIF2AK2 (see 1 fusions); DDX5 (see 1 fusions); HNRNPU/RPL24 (see 1 fusions); RPLP2 (see 1 fusions); RPS24/RPS23 (see 1 fusions); RPS24/RPS27 (see 1 fusions); RPL27/RPS6 (see 1 fusions); HUWE1 (see 2 fusions); EEF1A1/RPL12 (see 1 fusions); RPS4X/AHSA1 (see 1 fusions); RPL38/RPL3 (see 1 fusions); NCL (see 3 fusions); RPS19/RPS14 (see 1 fusions); TUBG1 (see 1 fusions); EEF1A1 (see 1 fusions); CUL3 (see 1 fusions); TP53 (see 3 fusions); KPNB1 (see 2 fusions); RACK1 (see 3 fusions); FN1/RPL6 (see 1 fusions); NPM1 (see 1 fusions); CUL1 (see 3 fusions); RPS5/RPL14 (see 1 fusions); CENPQ (see 1 fusions); APP (see 4 fusions); HSP90AA1 (see 2 fusions); HSP90AB1 (see 1 fusions); SKI (see 1 fusions); RACK1/FN1 (see 1 fusions); PUF60 (see 2 fusions); PABPC1 (see 2 fusions); MCM2 (see 1 fusions);

List of the fusions

PPI for parental proteins: HIST1H1C,ZNF90

All fusions

: CF128699;

Proteins found in more fusions

EIF2AK2 (see 1 fusions); DDX5 (see 1 fusions); HNRNPU/RPL24 (see 1 fusions); RPLP2 (see 1 fusions); RPS24/RPS23 (see 1 fusions); RPS24/RPS27 (see 1 fusions); RPL27/RPS6 (see 1 fusions); HUWE1 (see 2 fusions); EEF1A1/RPL12 (see 1 fusions); RPS4X/AHSA1 (see 1 fusions); RPL38/RPL3 (see 1 fusions); NCL (see 3 fusions); RPS19/RPS14 (see 1 fusions); TUBG1 (see 1 fusions); EEF1A1 (see 1 fusions); CUL3 (see 1 fusions); TP53 (see 3 fusions); KPNB1 (see 2 fusions); RACK1 (see 3 fusions); FN1/RPL6 (see 1 fusions); NPM1 (see 1 fusions); CUL1 (see 3 fusions); RPS5/RPL14 (see 1 fusions); CENPQ (see 1 fusions); APP (see 4 fusions); HSP90AA1 (see 2 fusions); HSP90AB1 (see 1 fusions); SKI (see 1 fusions); RACK1/FN1 (see 1 fusions); PUF60 (see 2 fusions); PABPC1 (see 2 fusions); MCM2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	CF128699	chimera	159	0.379	2912.158	Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
2	ACTA2	interactor	18	0.641	2.571	Actin (PF00022, IPR004000, SM00268): Actin
3	AHSA1	protein found in more fusions	34	0.661	28.676	Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
4	APP	protein found in more fusions	43	0.396	121.531	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5	ASB14	interactor	5	0.600	0.815	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
6	ASB15	interactor	2	1.000	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
7	ATP6V0D1	interactor	4	0.833	0.182	vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
8	AURKA	oncoprotein	38	0.557	31.903	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
9	AURKB	interactor	17	0.575	5.000	Pkinase (PF00069, IPR000719): Protein kinase domain
10	CAND1	interactor	98	0.632	197.729	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
11	CD81	interactor	44	0.759	14.570	Tetraspannin (PF00335, IPR018499): Tetraspanin family
12	CDC5L	interactor	27	0.563	26.828	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
13	CDH2	interactor	9	0.806	1.716	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like Cadherin (PF00028, IPR002126, SM00112): Cadherin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain Cadherin_3 (PF16184): Cadherin-like
14	CDK2	suppressor	75	0.639	94.526	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
15	CENPQ	protein found in more fusions	8	0.714	0.542	CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
16	CEP250	interactor	54	0.811	17.263	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
17	CEP57	interactor	20	0.842	1.801	Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57 Tup_N (PF08581, IPR013890): Tup N-terminal CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57 TRIQK (PF15168, IPR024842): Triple QxxK/R motif-containing protein family
18	CEP76	interactor	26	0.766	9.591	Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily CEP76-C2 (PF15627, IPR028926): CEP76 C2 domain
19	CKAP5	interactor	9	0.357	3.674	HEAT (PF02985, IPR000357): HEAT repeat PAS_6 (PF08348, IPR013559): YheO-like PAS domain UME (PF08064, IPR012993, SM00802): UME (NUC010) domain CLASP_N (PF12348, IPR024395): CLASP N terminal Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
20	CNBP	oncoprotein	13	0.808	0.620	zf-CCHC (PF00098, IPR001878): Zinc knuckle zf-ribbon_3 (PF13248): zinc-ribbon domain
21	CUL1	suppressor	90	0.661	111.591	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
22	CUL2	suppressor	66	0.690	60.896	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
23	CUL3	protein found in more fusions	93	0.610	223.371	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
24	CUL4B	oncoprotein	59	0.649	53.323	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
25	CUL5	suppressor	64	0.690	137.204	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
26	DDX5	oncoprotein	35	0.339	45.623	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
27	DDX56	interactor	22	0.701	3.871	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
28	DYNLT3	interactor	3	1.000	0	Tctex-1 (PF03645, IPR005334): Tctex-1 family
29	EED	suppressor	48	0.637	59.719	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
30	EEF1A1	suppressor	67	0.668	67.717	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
31	EEF2	interactor	49	0.699	24.392	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
32	EIF2A	interactor	12	0.576	3.946	Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
33	EIF2AK2	oncoprotein	12	0.655	2.390	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Pkinase (PF00069, IPR000719): Protein kinase domain
34	EIF3L	interactor	23	0.688	5.389	Paf67 (PF10255, IPR019382): RNA polymerase I-associated factor PAF67
35	ESR1	suppressor	66	0.722	44.012	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
36	ESRRB	suppressor	14	0.516	5.047	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
37	EXOSC1	interactor	7	0.571	2.423	EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4 ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
38	EXOSC5	interactor	6	0.600	1.735	RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1 RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
39	FAU	interactor	40	0.805	9.523	Ribosomal_S30 (PF04758, IPR006846): Ribosomal protein S30 ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
40	FN1	oncoprotein	84	0.649	151.010	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
41	HNRNPM	interactor	63	0.667	58.536	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
42	HNRNPU	protein found in more fusions	100	0.612	190.208	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
43	HSP90AA1	oncoprotein	54	0.466	107.952	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
44	HSP90AB1	oncoprotein	49	0.495	67.150	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
45	HUWE1	oncoprotein	55	0.667	45.749	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
46	ICAM1	oncoprotein	49	0.825	12.310	Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
47	IGSF8	oncoprotein	52	0.781	19.215	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
48	ILF2	interactor	62	0.605	120.854	DZF (PF07528, IPR006561, SM00572): DZF domain
49	ILF3	oncoprotein	75	0.639	158.655	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain
50	ITGA4	interactor	70	0.657	82.844	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
51	KPNB1	protein found in more fusions	23	0.355	14.757	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat
52	LARP1	interactor	27	0.769	5.508	La (PF05383, IPR006630, SM00715): La domain Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
53	LARP7	interactor	11	0.564	3.078	Agouti (PF05039, IPR007733, SM00792): Agouti protein DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) La (PF05383, IPR006630, SM00715): La domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 (PF08777, IPR014886): RNA binding motif
54	MAGEB2	interactor	15	0.876	0.736	MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
55	MCM2	oncoprotein	91	0.551	299.699	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
56	MLEC	interactor	2	1.000	0	Malectin (PF11721, IPR021720): Di-glucose binding within endoplasmic reticulum
57	NCL	protein found in more fusions	61	0.612	65.011	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1
58	NDRG1	suppressor	19	0.696	3.422	Ndr (PF03096, IPR004142): Ndr family
59	NEDD8	interactor	35	0.825	5.629	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
60	NOP56	interactor	68	0.737	65.731	Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
61	NPM1	suppressor	98	0.624	153.095	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
62	PABPC1	oncoprotein	61	0.618	72.170	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT
63	PAN2	interactor	72	0.781	38.693	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
64	PARK2	suppressor	34	0.587	26.897	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
65	PINX1	suppressor	10	0.556	3.211	G-patch (PF01585, IPR000467, SM00443): G-patch domain NR_Repeat (PF14046, IPR025900): Nuclear receptor repeat
66	PPT2	interactor	10	0.778	1.259	Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
67	PRKCDBP	suppressor	11	0.473	8.234	A1_Propeptide (PF07966, IPR012848): A1 Propeptide PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
68	PUF60	protein found in more fusions	14	0.679	1.341	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Titin_Z (PF09042, IPR015129): Titin Z TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
69	PYM1	interactor	26	0.880	2.960	CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD) Mago-bind (PF09282, IPR015362): Mago binding AAA_23 (PF13476): AAA domain
70	RACK1	suppressor	48	0.734	25.076	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
71	RAD21	oncoprotein	34	0.768	9.547	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
72	RPL10	suppressor	92	0.703	123.911	Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
73	RPL10L	interactor	63	0.881	11.984	Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e Cytochrome_P460 (PF16694, IPR032033): Cytochrome P460
74	RPL11	suppressor	104	0.667	143.364	Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5 Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
75	RPL12	protein found in more fusions	100	0.684	109.260	Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
76	RPL13	interactor	96	0.694	97.152	Ribosomal_L13e (PF01294, IPR001380): Ribosomal protein L13e
77	RPL13A	interactor	78	0.824	26.461	Ribosomal_L13 (PF00572, IPR005822): Ribosomal protein L13
78	RPL14	protein found in more fusions	105	0.638	213.226	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14 UPF0688 (PF15772, IPR031530): UPF0688 family
79	RPL15	interactor	93	0.748	60.975	Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15
80	RPL18	interactor	106	0.666	168.688	Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
81	RPL18A	interactor	85	0.766	57.863	Ribosomal_L18A (PF01775, IPR023573): Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
82	RPL19	interactor	94	0.719	98.392	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e
83	RPL21	interactor	103	0.656	213.090	Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
84	RPL22	oncoprotein	95	0.712	84.580	Ribosomal_L22e (PF01776, IPR002671): Ribosomal L22e protein family
85	RPL23	interactor	102	0.654	224.571	Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
86	RPL23A	interactor	110	0.620	222.956	Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23 Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
87	RPL24	protein found in more fusions	99	0.697	102.137	MAS20 (PF02064, IPR002056): MAS20 protein import receptor Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
88	RPL26	oncoprotein	58	0.773	28.739	TP2 (PF01254, IPR000678): Nuclear transition protein 2 Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
89	RPL26L1	interactor	47	0.808	10.495	Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
90	RPL27	protein found in more fusions	90	0.748	67.474	Ribosomal_L27e (PF01777, IPR001141): Ribosomal L27e protein family
91	RPL27A	interactor	89	0.735	88.771	Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
92	RPL28	interactor	43	0.818	10.402	Ribosomal_L28e (PF01778, IPR029004): Ribosomal L28e protein family
93	RPL29	interactor	35	0.839	6.785	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain Ribosomal_L29e (PF01779, IPR002673): Ribosomal L29e protein family
94	RPL3	protein found in more fusions	98	0.685	160.681	Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
95	RPL30	interactor	90	0.725	83.027	NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
96	RPL31	interactor	97	0.670	147.937	Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e
97	RPL32	interactor	57	0.841	25.679	Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
98	RPL34	interactor	65	0.789	42.886	Redoxin (PF08534, IPR013740): Redoxin Ribosomal_L34e (PF01199, IPR008195): Ribosomal protein L34e
99	RPL35	interactor	80	0.799	35.141	Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein XFP_N (PF09364, IPR018970): XFP N-terminal domain
100	RPL35A	interactor	63	0.867	20.136	Ribosomal_L35Ae (PF01247, IPR001780): Ribosomal protein L35Ae
101	RPL36	interactor	83	0.776	95.045	Ribosomal_L36e (PF01158, IPR000509): Ribosomal protein L36e
102	RPL37A	interactor	81	0.803	37.386	Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
103	RPL38	protein found in more fusions	78	0.780	49.596	Ribosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
104	RPL3L	interactor	32	0.956	1.643	Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
105	RPL4	interactor	105	0.666	129.120	Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
106	RPL5	suppressor	112	0.633	238.949	Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
107	RPL6	protein found in more fusions	110	0.624	224.843	Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
108	RPL7	interactor	98	0.710	84.276	Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
109	RPL7A	interactor	99	0.694	94.067	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
110	RPL8	interactor	99	0.668	192.295	Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
111	RPL9	interactor	98	0.680	224.704	Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
112	RPLP0	interactor	103	0.677	134.191	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
113	RPLP1	interactor	68	0.854	16.722	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
114	RPLP2	protein found in more fusions	87	0.747	60.522	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
115	RPS10P5	interactor	18	1.000	0	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
116	RPS11	interactor	101	0.644	194.709	Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17 Ribosomal_S17_N (PF16205, IPR032440): Ribosomal_S17 N-terminal
117	RPS12	interactor	80	0.777	46.444	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
118	RPS13	interactor	106	0.650	155.245	Ribosomal_S13_N (PF08069, IPR012606): Ribosomal S13/S15 N-terminal domain Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
119	RPS14	protein found in more fusions	107	0.620	227.074	Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
120	RPS15	interactor	76	0.791	36.189	Ribosomal_S19 (PF00203, IPR002222): Ribosomal protein S19 Prok_Ub (PF14454, IPR032866): Prokaryotic Ubiquitin
121	RPS15A	interactor	106	0.629	217.938	Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
122	RPS17	interactor	65	0.743	63.184	Ribosomal_S17e (PF00833, IPR001210): Ribosomal S17
123	RPS18	interactor	99	0.671	121.369	Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
124	RPS19	protein found in more fusions	101	0.648	193.742	Ribosomal_S19e (PF01090, IPR001266): Ribosomal protein S19e
125	RPS2	interactor	115	0.591	355.447	Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
126	RPS21	interactor	68	0.832	20.574	Ribosomal_S21e (PF01249, IPR001931): Ribosomal protein S21e
127	RPS23	protein found in more fusions	105	0.621	187.682	Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
128	RPS24	protein found in more fusions	92	0.709	91.969	Fascin (PF06268, IPR022768): Fascin domain Ribosomal_S24e (PF01282, IPR001976): Ribosomal protein S24e DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
129	RPS26	interactor	95	0.628	242.446	Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
130	RPS27	protein found in more fusions	80	0.751	84.052	Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27 DUF3795 (PF12675, IPR024227): Protein of unknown function (DUF3795)
131	RPS27A	interactor	53	0.779	28.379	DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
132	RPS27L	interactor	48	0.859	16.148	E7 (PF00527, IPR000148): E7 protein, Early protein Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27 zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
133	RPS28	interactor	70	0.748	53.327	Ribosomal_S28e (PF01200, IPR000289): Ribosomal protein S28e
134	RPS3	interactor	118	0.568	401.878	KH_2 (PF07650, IPR004044): KH domain Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
135	RPS3A	interactor	120	0.562	390.884	Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
136	RPS4X	protein found in more fusions	121	0.564	358.553	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain S4 (PF01479, IPR002942, SM00363): S4 domain 40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
137	RPS5	protein found in more fusions	92	0.720	94.155	Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
138	RPS6	protein found in more fusions	114	0.613	202.367	Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
139	RPS7	interactor	92	0.695	161.920	Ribosomal_S7e (PF01251, IPR000554): Ribosomal protein S7e
140	RPS8	interactor	115	0.604	262.796	Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
141	RPS9	interactor	103	0.640	172.244	Ribosomal_S4 (PF00163, IPR001912): Ribosomal protein S4/S9 N-terminal domain S4 (PF01479, IPR002942, SM00363): S4 domain
142	RPSA	interactor	90	0.730	84.616	Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2 40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
143	SFN	suppressor	38	0.767	13.158	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
144	SIRT7	interactor	59	0.586	110.667	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
145	SKI	oncoprotein	19	0.647	3.440	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
146	SMURF1	interactor	34	0.693	12.837	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
147	SND1	interactor	29	0.744	5.265	TUDOR (PF00567, IPR002999, SM00333): Tudor domain SNase (PF00565, IPR016071, SM00318): Staphylococcal nuclease homologue
148	TERF1	interactor	13	0.485	7.403	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
149	TP53	suppressor	75	0.624	116.338	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
150	TSR1	interactor	31	0.856	11.841	AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
151	TUBG1	protein found in more fusions	50	0.707	28.205	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
152	TUBGCP4	interactor	18	0.876	1.748	Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
153	TUFM	interactor	51	0.602	90.992	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
154	TXN2	interactor	5	1.000	0	Thioredoxin (PF00085, IPR013766): Thioredoxin
155	UBL4A	interactor	80	0.695	73.825	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
156	UQCRB	interactor	9	0.694	2.230	UCR_14kD (PF02271, IPR003197): Ubiquinol-cytochrome C reductase complex 14kD subunit
157	VAPA	interactor	15	0.410	24.238	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
158	VCAM1	interactor	71	0.661	80.742	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
159	XPO1	interactor	55	0.547	125.874	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
160	ZBTB1	interactor	25	0.910	1.335	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	ABCE1	interactor	ABC_tran (PF00005, IPR003439): ABC transporter Fer4 (PF00037, IPR001450): 4Fe-4S binding domain RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain AAA_29 (PF13555): P-loop containing region of AAA domain
2	AEBP2	interactor	Bindin (PF02084, IPR000775): Bindin Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box DUF4764 (PF15961, IPR031885): Domain of unknown function (DUF4764)
3	APEH	oncoprotein	Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
4	ARRB1	interactor	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5	ARRB2	interactor	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6	ASB16	interactor	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
7	ASB9	interactor	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
8	ASXL1	suppressor	HARE-HTH (PF05066, IPR007759): HB1, ASXL, restriction endonuclease HTH domain ASXH (PF13919, IPR028020): Asx homology domain PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
9	ATP5I	interactor	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
10	ATRX	oncoprotein	DDHD (PF02862, IPR004177, SM01127): DDHD domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region Pap_E4 (PF02711, IPR003861): E4 protein PHD (PF00628, IPR019787, SM00249): PHD-finger Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Zip (PF02535, IPR003689): ZIP Zinc transporter DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992) DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex FAM176 (PF14851): FAM176 family DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
11	CDC73	suppressor	CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
12	CDKN1A	suppressor	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
13	CENPA	interactor	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
14	COPS5	interactor	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
15	CSNK2A2	interactor	Pkinase (PF00069, IPR000719): Protein kinase domain
16	CTNNB1	oncoprotein	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
17	CTR9	interactor	DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) Pap_E4 (PF02711, IPR003861): E4 protein SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175) TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
18	CUL4A	interactor	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
19	DAXX	oncoprotein	Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Nop14 (PF04147, IPR007276): Nop14-like family RF-1 (PF00472, IPR000352): RF-1 domain Vpu (PF00558, IPR008187): Vpu protein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
20	DCAF1	interactor	DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) LisH (PF08513, IPR013720, SM00667): LisH ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
21	DDB1	interactor	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
22	DOT1L	oncoprotein	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DivIC (PF04977, IPR007060): Septum formation initiator DOT1 (PF08123, IPR013110): Histone methylation protein DOT1 ZapB (PF06005, IPR009252): Cell division protein ZapB HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
23	FIP1L1	oncoprotein	Fip1 (PF05182, IPR007854): Fip1 motif Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FAM176 (PF14851): FAM176 family Auts2 (PF15336): Autism susceptibility gene 2 protein
24	H1FX	interactor	IGPS (PF00218, IPR013798): Indole-3-glycerol phosphate synthase
25	HDAC5	interactor	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
26	HDGF	interactor	PWWP (PF00855, IPR000313, SM00293): PWWP domain
27	HIST1H1C	parental protein	Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
28	HIST1H2AD	interactor	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
29	HIST1H3A	interactor	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
30	HIST1H3E	interactor	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
31	HSP90AA5P	interactor	NA
32	HSPA5	oncoprotein	HSP70 (PF00012, IPR013126): Hsp70 protein
33	IL7R	interactor	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
34	IRAK4	interactor	Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
35	KPNA7	interactor	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
36	LEO1	interactor	Leo1 (PF04004, IPR007149): Leo1-like protein PPP4R2 (PF09184, IPR015267): PPP4R2 EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
37	LOC101929876	interactor	NA
38	MCM5	oncoprotein	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
39	NSD1	oncoprotein	PHD (PF00628, IPR019787, SM00249): PHD-finger PWWP (PF00855, IPR000313, SM00293): PWWP domain SET (PF00856, IPR001214, SM00317): SET domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
40	NTRK1	oncoprotein	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
41	OAS3	interactor	NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain OAS1_C (PF10421, IPR018952): 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
42	PAF1	oncoprotein	Paf1 (PF03985, IPR007133): Paf1 MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
43	PARP1	suppressor	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
44	PHF6	suppressor	zf-HC5HC2H (PF13771): PHD-like zinc-binding domain YqfQ (PF14181, IPR025571): YqfQ-like protein
45	POLR2A	interactor	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
46	PRKCA	interactor	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
47	PRKDC	interactor	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
48	RBM39	oncoprotein	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
49	RBM8A	interactor	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
50	RBX1	oncoprotein	zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
51	RNF146	interactor	WWE (PF02825, IPR004170, SM00678): WWE domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
52	RNF168	interactor	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
53	RNF2	interactor	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
54	RPL10A	interactor	Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
55	RPL17	interactor	Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
56	RPLP0P6	interactor	NA
57	RPS10	interactor	S10_plectin (PF03501, IPR005326): Plectin/S10 domain
58	RPS16	parental protein	Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
59	RPS20	interactor	Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
60	RPS25	interactor	Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
61	RPS29	interactor	Ribosomal_S14 (PF00253, IPR001209): Ribosomal protein S14p/S29e
62	SEC24D	interactor	Gelsolin (PF00626, IPR007123): Gelsolin repeat Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain Transp_Tc5_C (PF04236, IPR007350): Tc5 transposase C-terminal domain zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
63	SUZ12	suppressor	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
64	TARDBP	interactor	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
65	TBCD	interactor	HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal HEAT_EZ (PF13513): HEAT-like repeat
66	TONSL	interactor	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 (PF13424): Tetratricopeptide repeat LRR_6 (PF13516, IPR001611): Leucine Rich repeat Ank_4 (PF13637): Ankyrin repeats (many copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat Ank_5 (PF13857): Ankyrin repeats (many copies) UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
67	TOP1	oncoprotein	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor Sox_N (PF12444, IPR022151): Sox developmental protein N terminal Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) TonB_N (PF16031): TonB N-terminal region
68	TRIM29	interactor	MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family TP2 (PF01254, IPR000678): Nuclear transition protein 2 zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
69	UBASH3B	interactor	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain
70	VHL	suppressor	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain
71	WDR12	interactor	NLE (PF08154, IPR012972): NLE (NUC135) domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
72	WDR5	interactor	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
73	WDR61	interactor	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
74	YBX1	oncoprotein	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
75	YWHAQ	interactor	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
76	ZC3H3	interactor	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
77	ZNF22	interactor	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

B a c k t o T o p ⇑

Fusion ID: Protein names:	CF128699
Level of PPIs:	or Upload text file:	Update repository

Visible interactions:	all	affected	independent (normal)	missing	nothing (blank)
Chimeric state:	ordinary fusion	big fusion

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