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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)106
The number (and %) of the onco-proteins32 (30.19 %)
The number (and %) of the tumor suppressors17 (16.04 %)
Total number of binary PPIs (saturation %)719 (12.92 %)
The number (and %) of affected PPIs105 (14.60 %)
The number of possible different fusions25
PPI diameter2
PPI radius1
The average degree of PPI12.585
Assortativity coefficient-0.1588
The network average Clustering coefficient0.525
The number (and %) of a zero Clustering coefficients7 (6.60 %)
The number (and %) of a zero Betweenness Centrality16 (15.09 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ACTG1 All fusions
: CB409249;
Proteins found in more fusions HSP90AA1 (see 2 fusions); EEF1A1 (see 1 fusions); SH3GL2 (see 1 fusions); APOE (see 1 fusions); HSP90AB1 (see 1 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); CTBP2 (see 2 fusions); BCAP31 (see 3 fusions); MYC (see 1 fusions); SP1 (see 1 fusions); ERBB3 (see 2 fusions); CDH1 (see 3 fusions); ACTB (see 3 fusions); TOPBP1 (see 2 fusions); GAN (see 1 fusions); MCM2 (see 1 fusions); CTTN (see 1 fusions); KAT5 (see 3 fusions); SHC1 (see 1 fusions); EZH2 (see 1 fusions); LRRK2 (see 1 fusions); ERRFI1 (see 1 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CB409249chimera1050.1036545.586Actin (PF00022, IPR004000, SM00268): Actin
2 ACTA1interactor270.234171.228Actin (PF00022, IPR004000, SM00268): Actin
3 ACTBoncoprotein430.216453.608Actin (PF00022, IPR004000, SM00268): Actin
4 ACTBL2interactor120.34821.963Actin (PF00022, IPR004000, SM00268): Actin
5 ADRB2interactor60.6000.6917tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6 AICDAinteractor40.6670.133APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
7 ANLNoncoprotein130.9490.658Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
8 APOEprotein found in more fusions200Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
9 BCAP31protein found in more fusions50.6670.722Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
10 BMI1oncoprotein110.35617.838zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
11 BRCA1suppressor170.35050.732BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
12 BRK1interactor50.9000.500DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
13 CADoncoprotein140.45117.634Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain
CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
MGS (PF02142, IPR011607, SM00851): MGS-like domain
OTCace (PF00185, IPR006131): Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
OTCace_N (PF02729, IPR006132): Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
ATPgrasp_Ter (PF15632, IPR011226): ATP-grasp in the biosynthetic pathway with Ter operon
14 CAP1interactor100.44413.706CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
15 CAP2interactor50.5002.000CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
16 CAPZA2interactor220.55446.704F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
17 CCDC22interactor100DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
18 CCDC8interactor160.42923.673Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
19 CDH1suppressor70.5333.025Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
20 CDK2suppressor270.44064.524Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
21 CDKN2Asuppressor200.33269.846Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
22 CORO1Binteractor150.8293.991DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_4 (PF16300): Type of WD40 repeat
23 CORO1Concoprotein200.64220.746DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
WD40_4 (PF16300): Type of WD40 repeat
24 CTBP2protein found in more fusions31.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
25 CTNND1suppressor70.3336.902Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
26 CTTNoncoprotein180.51541.381FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
27 DBN1oncoprotein260.45284.922Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
28 DISC1interactor50.4005.400HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
29 DMAP1interactor90.6676.778DMAP1 (PF05499, IPR008468): DNA methyltransferase 1-associated protein 1 (DMAP1)
SANT_DAMP1_like (PF16282, IPR032563): SANT/Myb-like domain of DAMP1
30 EEDsuppressor140.41022.614WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31 EEF1A1suppressor280.245157.010GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
32 EEF1A2oncoprotein40.6670.419GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
33 EHHADHinteractor21.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
34 EIF6interactor30.6671.000eIF-6 (PF01912, IPR002769, SM00654): eIF-6 family
35 EPS8L1interactor21.0000PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
TetR_C_11 (PF16859, IPR011075): Bacterial transcriptional repressor C-terminal
36 EPS8L2interactor100PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
37 ERBB3oncoprotein120.49114.473Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
38 ERRFI1suppressor100.5566.344GTPase_binding (PF09027, IPR015116): GTPase binding
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
39 EZH2suppressor110.48911.945CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
40 FAF2interactor80.4297.825DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
41 FBXO6interactor110.4559.615FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
42 FEZ1interactor31.0000FEZ (PF07763, IPR011680): FEZ-like protein
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
43 FHOD1interactor50.6671.167Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
44 FLNAsuppressor320.411141.183CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
45 FN1oncoprotein240.41774.145fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
46 GANprotein found in more fusions80.3336.994BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
47 GIT2interactor200ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Sen15 (PF09631, IPR018593): Sen15 protein
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
48 GRB2oncoprotein280.368123.663SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
49 HSP90AA1oncoprotein300.288149.758HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
50 HSP90AB1oncoprotein300.308129.390HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
51 HSPA5oncoprotein290.323136.090HSP70 (PF00012, IPR013126): Hsp70 protein
52 HSPB2interactor70.4673.393Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
53 ILF3oncoprotein210.32465.449dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
54 IQGAP1interactor350.393149.539CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
55 ITGA4interactor160.56216.321FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
56 KAT5suppressor140.48722.224MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
57 LGR4interactor90.5364.1577tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
58 LIG4interactor40.5000.848APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
59 LIMA1suppressor250.50762.342LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
60 LRRK2oncoprotein150.38527.371Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
61 MCM2oncoprotein280.350121.490AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
62 MDKoncoprotein21.0000PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
63 MEPCEinteractor60.6001.866Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3)
Methyltransf_23 (PF13489): Methyltransferase domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
64 MLH1suppressor50.6001.800DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
65 MORF4L1interactor90.8211.519MRG (PF05712, IPR026541): MRG
Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
66 MORF4L2interactor80.8211.519MRG (PF05712, IPR026541): MRG
67 MRGBPinteractor70.9520.111Eaf7 (PF07904, IPR012423): Chromatin modification-related protein EAF7
68 MYConcoprotein170.39240.396HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
69 MYH9suppressor370.372196.466IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
70 MYO18Ainteractor200.67923.481Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
71 MYO19interactor170.8015.801IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
72 MYO1Cinteractor230.46259.642IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
73 MYO5Cinteractor160.72510.570DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD)
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
YtxH (PF12732, IPR024623): YtxH-like protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
74 MYOCinteractor60.8000.833IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
75 NCKAP1interactor60.5334.806Nckap1 (PF09735, IPR019137): Membrane-associated apoptosis protein
76 PDLIM7interactor90.6944.389LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
77 PFN2interactor50.5002.733Profilin (PF00235, IPR005455, SM00392): Profilin
78 PLD1suppressor100PH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
79 POU5F1oncoprotein90.39310.600Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
80 PPP1CBinteractor240.55443.581Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
81 PPP1CConcoprotein170.57422.395Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
82 PSEN2oncoprotein31.0000Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
Presenilin (PF01080, IPR001108): Presenilin
83 RNF2interactor150.26449.038zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
84 RPS6KA5interactor40.6670.900Choline_kinase (PF01633): Choline/ethanolamine kinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
85 RPS6KB2interactor100.4675.289Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
86 SFNsuppressor90.5005.87214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
87 SGF29interactor100DUF1325 (PF07039, IPR010750): SGF29 tudor-like domain
Filament (PF00038, IPR001664): Intermediate filament protein
88 SH3GL2oncoprotein31.0000BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
89 SHC1oncoprotein160.58113.510PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
90 SP1protein found in more fusions110.6225.470zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
91 SRPK2oncoprotein80.38111.233DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
92 ST3GAL3interactor100Glyco_transf_29 (PF00777, IPR001675): Glycosyltransferase family 29 (sialyltransferase)
93 SUZ12suppressor110.5567.762DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
94 TNIKinteractor30.6671.000CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499)
CNDH2_M (PF16869): PF16858
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
95 TOPBP1protein found in more fusions50.6670.733BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
96 TRAF2interactor90.35712.633MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
97 TRAF3IP1interactor80.5006.277MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
98 TSGA10interactor41.0000Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A3L (PF05288, IPR007952): Poxvirus A3L Protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
99 UBASH3Binteractor120.7643.591His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
100 UBE2Q2interactor41.0000Josephin (PF02099, IPR006155): Josephin
RWD (PF05773, IPR006575, SM00591): RWD domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
DUF2890 (PF11081, IPR021304): Protein of unknown function (DUF2890)
101 UBL4Ainteractor120.33318.743ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
102 VASPinteractor70.6672.222ASD2 (PF08687, IPR014799): Apx/Shroom domain ASD2
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
103 WASLinteractor70.7142.181Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
104 WIPF1interactor50.7001.567CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GRP (PF07172, IPR010800): Glycine rich protein family
WH2 (PF02205, IPR003124, SM00246): WH2 motif
105 YARSinteractor80.6796.440tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain
106 YWHAQinteractor200.35367.37014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACTG1parental proteinActin (PF00022, IPR004000, SM00268): Actin
2 CFL1interactorCofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
3 CFL2interactorCofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
4 COTL1oncoproteinCofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
5 DSTNinteractorCofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
6 FBXO25suppressorElongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
7 GZMAinteractorTrypsin (PF00089, IPR001254, SM00020): Trypsin
8 GZMKinteractorTrypsin (PF00089, IPR001254, SM00020): Trypsin
9 HIST1H3EinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
10 MAPK6oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
11 NDRG1suppressorNdr (PF03096, IPR004142): Ndr family
12 PRSS23interactorTrypsin (PF00089, IPR001254, SM00020): Trypsin
13 RANoncoproteinRas (PF00071, IPR001806, SM00173): Ras family
14 RBX1oncoproteinzf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
15 RUVBL1oncoproteinTIP49 (PF06068, IPR010339): TIP49 C-terminus
16 RUVBL2oncoproteinTIP49 (PF06068, IPR010339): TIP49 C-terminus
17 TMSB4XinteractorThymosin (PF01290, IPR001152, SM00152): Thymosin beta-4 family
18 UCHL5oncoproteinPeptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
19 VCLoncoproteinVinculin (PF01044, IPR006077): Vinculin family
20 WDYHV1interactorNt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase

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