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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins4 (15.38 %)
The number (and %) of the tumor suppressors2 (7.69 %)
Total number of binary PPIs (saturation %)65 (20.00 %)
The number (and %) of affected PPIs25 (38.46 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI4.615
Assortativity coefficient-0.4692
The network average Clustering coefficient0.503
The number (and %) of a zero Clustering coefficients6 (23.08 %)
The number (and %) of a zero Betweenness Centrality11 (42.31 %)


List of the fusions

PPI for parental proteins: MTX2 All fusions
: CA449952;
Proteins found in more fusions IMMT (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CA449952chimera250.117462.467Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
2 APOOLinteractor70.6672.400ApoO (PF09769, IPR019166): Apolipoprotein O
3 C19orf70interactor70.5246.400QIL1 (PF15884, IPR026769): Protein QIL1
4 CCDC155interactor100CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
EF-hand_9 (PF14658): EF-hand domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
5 CD244interactor21.0000Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
6 CEP120interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
DUF3668 (PF12416, IPR022136): Cep120 protein
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
7 CHCHD3interactor70.5245.733DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
eIF3g (PF12353, IPR024675): Eukaryotic translation initiation factor 3 subunit G
8 CHCHD6interactor40.6671.000CHCH (PF06747, IPR010625): CHCH domain
DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
9 EIF2B4interactor100IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
Mpp10 (PF04006, IPR007151): Mpp10 protein
10 HNRNPRinteractor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
11 IMMTprotein found in more fusions100.27821.733Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
12 KRASoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
13 MINOS1interactor50.5003.733DUF543 (PF04418, IPR007512): Domain of unknown function (DUF543)
14 MMGT1interactor70.4768.667MMgT (PF10270, IPR018937): Membrane magnesium transporter
15 MOV10interactor30.6671.000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
16 NDUFA4interactor60.5002.733B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
17 PHBsuppressor60.5337.000Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
18 PHB2interactor41.0000DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
19 PPP1CAsuppressor100Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
20 SAMM50interactor60.6672.400Bac_surface_Ag (PF01103, IPR000184): Surface antigen
POTRA (PF07244, IPR010827): Surface antigen variable number repeat
21 SLC25A3interactor40.5002.400Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
22 TADA2Ainteractor100SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
23 TPD52oncoprotein40.6671.000TPD52 (PF04201, IPR007327): Tumour protein D52 family
24 TRAK2interactor100ZapB (PF06005, IPR009252): Cell division protein ZapB
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Milton (PF12448, IPR022154): Kinesin associated protein
25 VDAC2interactor50.8001.333Porin_3 (PF01459, IPR027246): Eukaryotic porin
26 YWHAQinteractor21.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 MTX2parental proteinTom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain

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