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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: CA442157 is the fusion of parental proteins PPP1R15A, TAGLN2 (from a repository: Sun May 7 20:19:13 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins16 (51.61 %)
The number (and %) of the tumor suppressors2 (6.45 %)
Total number of binary PPIs (saturation %)97 (20.86 %)
The number (and %) of affected PPIs30 (30.93 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI5.355
Assortativity coefficient-0.2816
The network average Clustering coefficient0.591
The number (and %) of a zero Clustering coefficients4 (12.90 %)
The number (and %) of a zero Betweenness Centrality11 (35.48 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PPP1R15A,TAGLN2 All fusions
: CA442157;
Proteins found in more fusions KMT2A (see 16 fusions); SMARCB1 (see 12 fusions); CUL7 (see 2 fusions); COPS5 (see 1 fusions); BRD2 (see 5 fusions); CTBP2 (see 2 fusions); LYN (see 2 fusions); IKBKB (see 2 fusions); CUL3 (see 1 fusions); LMNA (see 3 fusions); TSN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CA442157chimera300.122642.867PPP4R2 (PF09184, IPR015267): PPP4R2
PP1c_bdg (PF10488, IPR019523): Phosphatase-1 catalytic subunit binding region
2 ACAA2interactor100Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3 BAG1oncoprotein30.6670.500BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
4 BCAR1oncoprotein21.0000Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
5 BRD2oncoprotein50.5002.000AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
6 CAND1interactor90.6076.233Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7 COPS5protein found in more fusions110.46715.467JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
8 CTBP2protein found in more fusions31.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
9 CUEDC2interactor31.0000CUE (PF02845, IPR003892, SM00546): CUE domain
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
10 CUL3protein found in more fusions120.45521.633Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
11 CUL7protein found in more fusions50.8330.500ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
12 DHX36interactor41.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
13 ECI1interactor100ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
14 EIF2S1interactor40.6672.000EIF_2_alpha (PF07541, IPR011488): Eukaryotic translation initiation factor 2 alpha subunit
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
15 HABP4interactor100HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
16 HIST1H2BGoncoprotein70.33313.167Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
17 IGBP1interactor21.0000TAP42 (PF04177, IPR007304): TAP42-like family
18 IKBKBprotein found in more fusions60.7002.067FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
19 KMT2Aoncoprotein40.6670.667AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus
FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SET (PF00856, IPR001214, SM00317): SET domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
20 LMNAprotein found in more fusions70.4675.733Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
21 LYNoncoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
22 MOV10interactor50.7001.833AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
23 NXF1interactor90.42912.833NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
24 OBSL1interactor70.5335.333BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
25 PPP1CAsuppressor90.44416.900Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
26 PPP1CBinteractor50.9000.400Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
27 PPP1CConcoprotein60.6003.900Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
28 RAD21oncoprotein21.0000Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
29 SMARCB1suppressor90.5718.967SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
30 TSNprotein found in more fusions200Translin (PF01997, IPR002848): Translin family
31 ZNF512Binteractor30.6671.000YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AHCYL1suppressorAdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
2 ALDOAinteractorGlycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
3 ALDOCinteractorGlycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
4 APPinteractorAPP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ARL8AinteractorArf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
6 ASS1suppressorArginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
7 ATF2oncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
8 ATOX1interactorHMA (PF00403, IPR006121): Heavy-metal-associated domain
9 ATP5BinteractorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
10 CACYBPinteractorCS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
11 CDK2suppressorKdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
12 CFL1interactorCofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
13 CLIC3interactorGST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
14 CLIC4oncoproteinGST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
15 COTL1oncoproteinCofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
16 CPLX1interactorSynaphin (PF05835, IPR008849): Synaphin protein
17 CRIP1interactorLIM (PF00412, IPR001781, SM00132): LIM domain
18 DAZAP1interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
19 DUTinteractordUTPase (PF00692, IPR008180): dUTPase
20 EEF2interactorEFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
21 EHD2interactorDynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
22 EIF1BoncoproteinSUI1 (PF01253, IPR001950): Translation initiation factor SUI1
23 EIF5A2interactorEFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
24 EIF5AL1interactorEFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
25 ENO1oncoproteinEnolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
26 ENO2interactorEnolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
27 ENO3interactorEnolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
28 EPB41suppressor4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
SAB (PF04382, IPR007477): SAB domain
29 EZRinteractorDUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
30 FABP3suppressorLipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
31 FABP5interactorLipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
32 FABP7interactorLipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
33 FKBP1AinteractorFKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
34 FKBP1BinteractorFKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
35 FKBP2interactorFKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
36 FN1oncoproteinfn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
37 GDI1interactorGDI (PF00996, IPR018203): GDP dissociation inhibitor
38 GPX4interactorGSHPx (PF00255, IPR000889): Glutathione peroxidase
39 GSTO1interactorGST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
40 GSTO2interactorGST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
41 HINT1suppressorHIT (PF01230, IPR001310): HIT domain
42 HSD17B10interactoradh_short (PF00106, IPR002198): short chain dehydrogenase
43 HSDL2interactoradh_short (PF00106, IPR002198): short chain dehydrogenase
SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family
44 HSPA4interactorHerpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
45 HSPA4LinteractorHSP70 (PF00012, IPR013126): Hsp70 protein
46 HSPA5oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
47 HSPA8oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
48 HSPE1interactorCpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
49 HSPH1oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
50 ITGA4interactorFG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
51 LIG4interactorAPG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
52 LTA4HinteractorLeuk-A4-hydro_C (PF09127, IPR015211): Leukotriene A4 hydrolase, C-terminal
Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
53 MCM2oncoproteinAAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
54 MDC1suppressorFHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
55 MSNoncoproteinDUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
56 MTAPsuppressorPNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
57 MTHFD1LinteractorFTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
58 NAXDinteractorCarb_kinase (PF01256, IPR000631): Carbohydrate kinase
GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
59 NME1-NME2interactorNDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
60 NME2interactorNDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
61 NUTF2interactorNTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
62 PDIA3interactorThioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
63 PGAM1interactorHis_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
64 PGK1interactorPGK (PF00162, IPR001576): Phosphoglycerate kinase
65 PHBsuppressorBand_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
66 PIN1suppressorRotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
67 PLS3interactorCH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
68 PMP2interactorLipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
69 PPIAinteractorPro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
70 PPIL3interactorPro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
71 PPP1R15Aparental proteinFSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
PP1c_bdg (PF10488, IPR019523): Phosphatase-1 catalytic subunit binding region
SCHIP-1 (PF10148, IPR015649): Schwannomin-interacting protein 1
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
72 PPP1R1AoncoproteinDARPP-32 (PF05395, IPR008466): Protein phosphatase inhibitor 1/DARPP-32
73 PSAT1interactorAminotran_5 (PF00266, IPR000192): Aminotransferase class-V
74 RAB10oncoproteinRas (PF00071, IPR001806, SM00173): Ras family
75 RAE1interactorExonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
76 RDXinteractorERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
77 RPA1suppressorRep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
78 RPA2oncoproteinRPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
79 RPA3interactorRep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
80 SLC33A1interactorAcatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
81 SMAD7interactorMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
82 SNRPFinteractorLSM (PF01423, IPR001163): LSM domain
83 SNX12interactorPX (PF00787, IPR001683, SM00312): PX domain
84 SNX3interactorPX (PF00787, IPR001683, SM00312): PX domain
85 SOD1interactorSod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
86 SPRinteractoradh_short (PF00106, IPR002198): short chain dehydrogenase
87 SSSCA1interactorAuto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
88 STIP1interactorTPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
89 SUMO3interactorRad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
90 TAGLN2parental proteinCalponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
91 TAGLN3interactorCalponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
92 TIGD6interactorCENP-B_N (PF04218, IPR007889): CENP-B N-terminal DNA-binding domain
DDE_1 (PF03184, IPR004875): DDE superfamily endonuclease
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
DUF3837 (PF12939, IPR024212): Domain of unknown function (DUF3837)
93 TKTinteractorTransket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
94 TKTL2interactorTransket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
95 TMEM189-UBE2V1interactorMARVEL (PF01284, IPR008253): Membrane-associating domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
TMEM189_B_dmain (PF10520, IPR019547): B domain of TMEM189, localisation domain
96 TOMM40interactorPorin_3 (PF01459, IPR027246): Eukaryotic porin
97 TXNoncoproteinThioredoxin (PF00085, IPR013766): Thioredoxin
98 TXNDC16interactorThioredoxin (PF00085, IPR013766): Thioredoxin
DUF4147 (PF13660, IPR025286): Domain of unknown function (DUF4147)
Thioredoxin_6 (PF13848): Thioredoxin-like domain
99 U2AF2interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
100 UBE2ConcoproteinUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
101 UBE2V1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
102 UCHL3interactorPeptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
103 UFC1interactorUFC1 (PF08694, IPR014806): Ubiquitin-fold modifier-conjugating enzyme 1
104 USP1interactorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
105 VCAM1interactorC2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
106 VHLsuppressorTrypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
107 YKT6interactorSynaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain

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