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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)126
The number (and %) of the onco-proteins45 (35.71 %)
The number (and %) of the tumor suppressors26 (20.63 %)
Total number of binary PPIs (saturation %)779 (9.89 %)
The number (and %) of affected PPIs125 (16.05 %)
The number of possible different fusions30
PPI diameter2
PPI radius1
The average degree of PPI11.222
Assortativity coefficient-0.2930
The network average Clustering coefficient0.498
The number (and %) of a zero Clustering coefficients10 (7.94 %)
The number (and %) of a zero Betweenness Centrality24 (19.05 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: IKBKB All fusions
: CA436950;
Proteins found in more fusions TAB2 (see 1 fusions); TRAF6 (see 1 fusions); HSP90AA1 (see 2 fusions); PRKCD (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); HSP90AB1 (see 1 fusions); NFKB1 (see 2 fusions); MAP3K1 (see 1 fusions); FAF1 (see 2 fusions); MAPK14 (see 1 fusions); TNFRSF1A (see 2 fusions); CREBBP (see 6 fusions); NEDD4L (see 3 fusions); CD40 (see 2 fusions); EIF2AK2 (see 1 fusions); PRKDC (see 3 fusions); RIPK1 (see 1 fusions); HTT (see 1 fusions); HSPB1 (see 4 fusions); COPS5 (see 1 fusions); FANCA (see 1 fusions); MAP3K7 (see 7 fusions); CDC37 (see 2 fusions); MTOR (see 1 fusions); RPTOR (see 3 fusions); PRKCE (see 3 fusions); HOMER3 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CA436950chimera1260.0759910.619Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus
2 AKT1oncoprotein290.235182.152PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 AURKAoncoprotein180.38243.919Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
4 BCL2oncoprotein100.3899.956Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
5 BIRC3oncoprotein140.64111.059BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
6 BRAPinteractor60.4003.900BRAP2 (PF07576, IPR011422): BRCA1-associated protein 2
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
7 BTRConcoprotein240.32088.774WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
8 CASP8suppressor150.44029.357DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
9 CD40protein found in more fusions70.6673.400Glycophorin_A (PF01102, IPR001195): Glycophorin A
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
10 CDC37protein found in more fusions180.39037.601CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
11 CDKN2Asuppressor100.5567.812Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
12 CLTConcoprotein110.41813.376Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
13 COPS3interactor110.5827.845RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
14 COPS4interactor90.6673.396DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
15 COPS5protein found in more fusions260.267128.549JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
16 COPS7Ainteractor70.8101.383PCI (PF01399, IPR000717, SM00088): PCI domain
17 CREBBPsuppressor140.43621.613Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
18 CSF2RAinteractor200IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
19 CSF2RBinteractor31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL4Ra_N (PF09238, IPR015319): Interleukin-4 receptor alpha chain, N-terminal
IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Tissue_fac (PF01108, IPR003961): Tissue factor
20 CSNK2Binteractor110.42211.219CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
21 CTNNB1oncoprotein210.27692.633Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
22 CUEDC2interactor31.0000CUE (PF02845, IPR003892, SM00546): CUE domain
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
23 CUL1suppressor240.289106.300Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
24 CUL3protein found in more fusions300.204210.525Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
25 DHCR24interactor21.0000FAD_binding_4 (PF01565, IPR006094): FAD binding domain
26 DPP4suppressor100DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
27 DUSP1suppressor30.6671.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
28 EIF2AK2oncoprotein120.41814.369dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Pkinase (PF00069, IPR000719): Protein kinase domain
29 ERC1oncoprotein70.4765.852RBD-FIP (PF09457, IPR019018): FIP domain
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
30 FAF1protein found in more fusions110.37818.522UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
31 FANCAoncoprotein50.8330.182Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein
Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
32 FKBP4interactor60.6672.152FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
33 FKBP5interactor90.6119.800FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NuDC (PF16273, IPR032572): Nuclear distribution C domain
34 FLNCinteractor30.6670.400CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
35 FOXO3suppressor80.5365.802Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
36 GLI1suppressor50.7001.833zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
37 HNRNPUinteractor110.52711.380CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
38 HOMER3protein found in more fusions200COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
WH1 (PF00568, IPR000697, SM00461): WH1 domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
39 HSP90AA1oncoprotein410.205369.233HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
40 HSP90AB1oncoprotein250.308103.166HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
41 HSPB1oncoprotein150.45126.271HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
42 HTTprotein found in more fusions110.42210.963HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
43 IKBKAPinteractor80.4764.686IKI3 (PF04762, IPR006849): IKI3 family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
44 IKBKEinteractor150.39628.997IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
45 IKBKGinteractor560.162877.410CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
46 IRAK1interactor200.36362.363Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
47 IRS1interactor70.4766.289CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
48 ITCHinteractor140.29533.918C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
49 JUNoncoprotein130.36419.513bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
50 KEAP1oncoprotein90.5364.784BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
51 LATS2suppressor70.5335.000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
52 MACROD1oncoprotein50.5002.083DUF1108 (PF06531, IPR009494): Protein of unknown function (DUF1108)
DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502)
Macro (PF01661, IPR002589, SM00506): Macro domain
53 MAP3K1oncoprotein90.3936.689zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
54 MAP3K11interactor90.6432.755APG6 (PF04111, IPR007243): Autophagy protein Apg6
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
55 MAP3K13interactor31.0000DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
56 MAP3K14interactor120.6188.348Pkinase (PF00069, IPR000719): Protein kinase domain
57 MAP3K7oncoprotein290.272152.677Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
58 MAPK14oncoprotein180.26564.460Pkinase (PF00069, IPR000719): Protein kinase domain
59 MAVSinteractor130.59110.117Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
60 MEOX2interactor30.6670.500Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
61 MTORoncoprotein150.40728.702DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
62 MUC1oncoprotein90.4449.583SEA (PF01390, IPR000082, SM00200): SEA domain
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
Collectrin (PF16959, IPR031588): Renal amino acid transporter
63 NAA20interactor100Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
64 NCOA3oncoprotein100.48911.678DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
65 NEDD4Lsuppressor200WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
66 NFKB1suppressor180.39041.722Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
67 NFKBIAoncoprotein230.289102.178Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
68 NFKBIBinteractor80.6795.550Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
69 NGFRsuppressor51.0000LHC (PF00556, IPR000066): Antenna complex alpha/beta subunit
70 NLRC5interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
AAA_16 (PF13191): AAA ATPase domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
71 NLRP2oncoprotein50.5003.133LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
AAA_16 (PF13191): AAA ATPase domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
72 NLRX1interactor40.6671.167NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
AAA_16 (PF13191): AAA ATPase domain
AAA_22 (PF13401, IPR003593): AAA domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
73 PELI1interactor50.5002.329Pellino (PF04710, IPR006800): Pellino
74 PLK1suppressor100.40012.766Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
75 PPARGsuppressor130.42421.205zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
76 PPM1Binteractor60.5333.883PP2C (PF00481, IPR001932): Protein phosphatase 2C
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
77 PPP1CAsuppressor140.29738.618Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
78 PPP1R15Ainteractor50.7002.000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
PP1c_bdg (PF10488, IPR019523): Phosphatase-1 catalytic subunit binding region
SCHIP-1 (PF10148, IPR015649): Schwannomin-interacting protein 1
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
79 PPP2CAsuppressor150.28643.485Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
80 PPP2R3Cinteractor21.0000DUF61 (PF01886, IPR002746): Protein of unknown function DUF61
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
81 PRDX3interactor80.4299.567AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
82 PRKCAinteractor90.3938.651C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
83 PRKCBsuppressor90.5367.988C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
84 PRKCDsuppressor130.36420.929Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
85 PRKCEsuppressor60.9000.286C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
86 PRKCIinteractor70.4768.432PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
87 PRKCQinteractor70.7330.978Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
88 PRKDCprotein found in more fusions120.50910.507FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
89 PYCARDsuppressor40.6670.500CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
90 PYGLinteractor31.0000Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
91 RANoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
92 RELAoncoprotein250.268122.088DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
93 RICTORinteractor90.41710.867RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term
RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain
RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
94 RIPK1protein found in more fusions180.43440.903Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
95 ROCK1interactor100FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
ZapB (PF06005, IPR009252): Cell division protein ZapB
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
PH (PF00169, IPR001849, SM00233): PH domain
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
Rho_Binding (PF08912, IPR015008): Rho Binding
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
96 RPTORprotein found in more fusions80.7622.133HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
97 SASH1suppressor41.0000PGA2 (PF07543, IPR011431): Protein trafficking PGA2
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
98 SHARPINinteractor61.0000DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Sharpin_PH (PF16764, IPR031912): Sharpin PH domain
99 SLC25A13interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
100 SLC25A22interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
DUF4257 (PF14074, IPR025353): Protein of unknown function (DUF4257)
101 SRConcoprotein150.45120.849Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
102 STAP2interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
103 STK26interactor50.5002.333DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
104 TAB1interactor130.47418.474PP2C (PF00481, IPR001932): Protein phosphatase 2C
105 TAB2oncoprotein130.57610.701CUE (PF02845, IPR003892, SM00546): CUE domain
DivIC (PF04977, IPR007060): Septum formation initiator
Mnd1 (PF03962, IPR005647): Mnd1 family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
106 TFAP2Cinteractor21.0000TF_AP-2 (PF03299, IPR013854): Transcription factor AP-2
107 TNFAIP3suppressor170.50026.868OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
108 TNFRSF1Aoncoprotein200.39262.129Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
109 TNIP2interactor50.8000.900PCRF (PF03462, IPR005139, SM00937): PCRF domain
EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55
zf-C2H2_4 (PF13894): C2H2-type zinc finger
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
110 TP53suppressor400.170420.497DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
111 TP63suppressor100.5289.891Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
112 TP73suppressor70.5333.015P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
113 TPX2interactor40.6670.600Aurora-A_bind (PF09041, IPR015128): Aurora-A binding
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
DUF2259 (PF10016, IPR018725): Predicted secreted protein (DUF2259)
TPX2_importin (PF12214, IPR027330): Cell cycle regulated microtubule associated protein
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
114 TRAF1oncoprotein160.57120.603HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
115 TRAF2interactor280.319124.554MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
116 TRAF3IP2interactor90.7143.340SEFIR (PF08357, IPR013568): SEFIR domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
117 TRAF6protein found in more fusions310.257200.749SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
118 TRAPPC9interactor100PMBR (PF09373, IPR018975): Pseudomurein-binding repeat
TRAPPC9-Trs120 (PF08626, IPR013935): Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
Vps23_core (PF09454, IPR017916): Vps23 core domain
119 TRIM21interactor60.4004.667DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
120 TRIM27oncoprotein80.33312.452IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
121 TRIM40interactor21.0000Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
CRR7 (PF12095, IPR021954): Protein CHLORORESPIRATORY REDUCTION 7
Dzip-like_N (PF13815, IPR032714): Iguana/Dzip1-like DAZ-interacting protein N-terminal
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
122 TRPC4APinteractor70.7141.863Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus
DUF3689 (PF12463, IPR022162): Protein of unknown function (DUF3689)
123 TSC1suppressor50.6670.667Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Hamartin (PF04388, IPR007483): Hamartin protein
124 TWIST1oncoprotein60.6003.369ACC_epsilon (PF13822, IPR032716): Acyl-CoA carboxylase epsilon subunit
PRR20 (PF15708, IPR031439): Proline-rich protein family 20
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
125 USP18interactor51.0000TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
126 USP4oncoprotein110.44418.748UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BCL10suppressorCARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
2 CHUKsuppressorPkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
3 COMMD7interactorCOMM_domain (PF07258): COMM domain
4 EGLN3suppressor2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
5 IKBKBparental proteinFliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
6 TNFoncoproteinTNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family

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