Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	141
The number (and %) of the onco-proteins	53 (37.59 %)
The number (and %) of the tumor suppressors	30 (21.28 %)
Total number of binary PPIs (saturation %)	980 (9.93 %)
The number (and %) of affected PPIs	140 (14.29 %)
The number of possible different fusions	34
PPI diameter	2
PPI radius	1
The average degree of PPI	13.021
Assortativity coefficient	-0.2359
The network average Clustering coefficient	0.543
The number (and %) of a zero Clustering coefficients	12 (8.51 %)
The number (and %) of a zero Betweenness Centrality	31 (21.99 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: NFKB1	All fusions : CA313276;
Proteins found in more fusions	TAB2 (see 1 fusions); SMAD4 (see 2 fusions); CUL4A (see 4 fusions); ELF3 (see 2 fusions); VCP (see 4 fusions); NR3C1 (see 8 fusions); GSK3B (see 1 fusions); COMMD1 (see 1 fusions); PPME1 (see 1 fusions); CUL3 (see 1 fusions); HSP90AB1 (see 1 fusions); HDAC4 (see 1 fusions); NCOA1 (see 2 fusions); NCOA6 (see 1 fusions); VPS26A (see 1 fusions); YY1 (see 2 fusions); GLUL (see 4 fusions); SP1 (see 1 fusions); STAT3 (see 2 fusions); SF1 (see 1 fusions); HIF1AN (see 1 fusions); KAT5 (see 3 fusions); POLR2A (see 2 fusions); RXRA (see 2 fusions); COPS5 (see 1 fusions); HDAC5 (see 1 fusions); IKBKB (see 2 fusions); PARP1 (see 1 fusions); EP300 (see 1 fusions); TSC22D3 (see 2 fusions); PML (see 4 fusions); CLU (see 5 fusions); COMMD6 (see 1 fusions);

List of the fusions

PPI for parental proteins: NFKB1

All fusions

: CA313276;

Proteins found in more fusions

TAB2 (see 1 fusions); SMAD4 (see 2 fusions); CUL4A (see 4 fusions); ELF3 (see 2 fusions); VCP (see 4 fusions); NR3C1 (see 8 fusions); GSK3B (see 1 fusions); COMMD1 (see 1 fusions); PPME1 (see 1 fusions); CUL3 (see 1 fusions); HSP90AB1 (see 1 fusions); HDAC4 (see 1 fusions); NCOA1 (see 2 fusions); NCOA6 (see 1 fusions); VPS26A (see 1 fusions); YY1 (see 2 fusions); GLUL (see 4 fusions); SP1 (see 1 fusions); STAT3 (see 2 fusions); SF1 (see 1 fusions); HIF1AN (see 1 fusions); KAT5 (see 3 fusions); POLR2A (see 2 fusions); RXRA (see 2 fusions); COPS5 (see 1 fusions); HDAC5 (see 1 fusions); IKBKB (see 2 fusions); PARP1 (see 1 fusions); EP300 (see 1 fusions); TSC22D3 (see 2 fusions); PML (see 4 fusions); CLU (see 5 fusions); COMMD6 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	CA313276	chimera	140	0.080	11734.095	Death (PF00531, IPR000488, SM00005): Death domain Myco_arth_vir_N (PF09610, IPR011732): Mycoplasma virulence signal region (Myco_arth_vir_N) RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
2	ABCC2	interactor	1	0	0	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter DUF805 (PF05656, IPR008523): Protein of unknown function (DUF805) DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
3	ANXA4	interactor	1	0	0	Annexin (PF00191, IPR018502, SM00335): Annexin
4	AURKA	oncoprotein	17	0.442	22.734	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
5	BANP	suppressor	7	0.867	0.368	DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845) BEN (PF10523, IPR018379, SM01025): BEN domain
6	BCL3	oncoprotein	15	0.457	18.683	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
7	BIRC3	oncoprotein	8	0.476	3.922	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
8	BRMS1	suppressor	12	0.527	6.641	Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family Sds3 (PF08598, IPR013907): Sds3-like
9	BTRC	oncoprotein	27	0.363	96.435	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
10	CARM1	oncoprotein	13	0.462	17.113	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
11	CD82	suppressor	1	0	0	Tetraspannin (PF00335, IPR018499): Tetraspanin family
12	CEBPB	oncoprotein	18	0.515	22.552	RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
13	CHUK	suppressor	22	0.462	40.272	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
14	CLU	suppressor	8	0.619	2.570	Clusterin (PF01093, IPR000753): Clusterin
15	COMMD1	protein found in more fusions	23	0.359	94.447	COMMD1_N (PF17221): COMMD1 N-terminal domain COMM_domain (PF07258): COMM domain
16	COMMD10	interactor	10	0.867	1.833	BPL_N (PF09825, IPR019197): Biotin-protein ligase, N terminal COMM_domain (PF07258): COMM domain
17	COMMD2	interactor	10	0.844	2.767	COMM_domain (PF07258): COMM domain
18	COMMD3	interactor	9	0.778	3.300	COMM_domain (PF07258): COMM domain
19	COMMD4	interactor	11	0.782	4.633	COMM_domain (PF07258): COMM domain
20	COMMD5	interactor	9	0.944	0.500	COMM_domain (PF07258): COMM domain
21	COMMD6	protein found in more fusions	10	0.556	10.250	COMM_domain (PF07258): COMM domain
22	COMMD8	interactor	10	0.800	4.476	COMM_domain (PF07258): COMM domain
23	COMMD9	interactor	5	0.800	0.583	COR (PF16095, IPR032171): C-terminal of Roc, COR, domain CDT1_C (PF16679, IPR032054): DNA replication factor Cdt1 C-terminal domain COMM_domain (PF07258): COMM domain
24	COPB2	interactor	5	0.667	0.422	Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
25	COPS5	protein found in more fusions	30	0.251	175.112	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
26	COPS6	interactor	16	0.429	37.441	DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
27	CTNNB1	oncoprotein	29	0.313	121.428	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
28	CUL3	protein found in more fusions	30	0.246	192.256	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
29	CUL4A	protein found in more fusions	16	0.600	14.830	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
30	CUL4B	oncoprotein	15	0.524	23.844	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
31	CUL5	suppressor	17	0.500	31.780	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
32	DCUN1D1	interactor	12	0.682	9.943	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
33	DNMT3L	interactor	9	0.500	5.832	CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
34	DPF1	interactor	2	1.000	0	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. PHD_4 (PF16866, IPR019787): PHD-finger
35	DPF2	interactor	8	0.536	5.918	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
36	DPF3	interactor	2	1.000	0	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. Lar_restr_allev (PF14354): Restriction alleviation protein Lar
37	E2F1	suppressor	15	0.390	28.498	Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
38	ECSIT	interactor	3	1.000	0	ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
39	ELF1	interactor	4	0.833	0.667	Ets (PF00178, IPR000418, SM00413): Ets-domain PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region Elf-1_N (PF12310, IPR022084): Transcription factor protein N terminal
40	ELF3	oncoprotein	5	1.000	0	AT_hook (PF02178, IPR017956, SM00384): AT hook motif Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
41	EP300	oncoprotein	50	0.221	506.749	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
42	ETS1	oncoprotein	7	0.667	2.241	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
43	FBXW11	interactor	11	0.644	4.144	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
44	GLUL	protein found in more fusions	2	0	0	Gln-synt_C (PF00120, IPR008146): Glutamine synthetase, catalytic domain Gln-synt_N (PF03951, IPR008147): Glutamine synthetase, beta-Grasp domain
45	GSK3B	suppressor	23	0.299	72.023	Pkinase (PF00069, IPR000719): Protein kinase domain
46	HDAC1	suppressor	36	0.276	227.264	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
47	HDAC2	suppressor	23	0.320	76.275	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
48	HDAC3	suppressor	27	0.363	86.557	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
49	HDAC4	oncoprotein	19	0.392	37.690	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
50	HDAC5	protein found in more fusions	22	0.362	63.275	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
51	HIF1AN	protein found in more fusions	8	0.667	1.708	Cupin_8 (PF13621): Cupin-like domain
52	HMGA1	oncoprotein	9	0.528	8.694	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
53	HMGA2	oncoprotein	2	1.000	0	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF1639 (PF07797, IPR012438): Protein of unknown function (DUF1639)
54	HMGB1	oncoprotein	4	0.667	0.583	HMG_box_2 (PF09011, IPR009071): HMG-box domain NOA36 (PF06524, IPR010531): NOA36 protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
55	HSP90AB1	oncoprotein	17	0.408	33.210	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
56	HSPA1L	interactor	12	0.545	14.045	HSP70 (PF00012, IPR013126): Hsp70 protein
57	HSPA4	interactor	24	0.301	92.623	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
58	IKBKB	protein found in more fusions	19	0.431	33.808	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
59	IKBKG	interactor	21	0.368	52.513	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
60	IRF2	interactor	4	0.833	0.500	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
61	IRF8	suppressor	6	0.600	2.077	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
62	IRF9	interactor	2	1.000	0	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
63	ITGB3BP	interactor	4	1.000	0	CENP-R (PF06729, IPR009601): Kinetochore component, CENP-R
64	KAT5	suppressor	16	0.514	17.672	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
65	KLF5	suppressor	14	0.582	8.577	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
66	KPNA3	interactor	4	0.500	1.083	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
67	LYL1	oncoprotein	2	1.000	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
68	MAP3K8	suppressor	8	0.821	1.832	Pkinase (PF00069, IPR000719): Protein kinase domain IML1 (PF12257, IPR027244): Vacuolar membrane-associated protein Iml1
69	MEN1	suppressor	8	0.571	3.489	Menin (PF05053, IPR007747): Menin
70	MPP6	interactor	1	0	0	L27 (PF02828, IPR014775, SM00569): L27 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
71	MTPN	interactor	3	1.000	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
72	MXD3	interactor	1	0	0	Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain HTH_20 (PF12840, IPR011991): Helix-turn-helix domain
73	NCOA1	oncoprotein	23	0.351	74.673	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
74	NCOA3	oncoprotein	22	0.381	63.421	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
75	NCOA6	oncoprotein	13	0.667	6.073	DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Presenilin (PF01080, IPR001108): Presenilin DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region NST1 (PF13945, IPR025279): Salt tolerance down-regulator
76	NCOR1	oncoprotein	21	0.448	41.305	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
77	NCOR2	oncoprotein	30	0.386	104.902	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
78	NFKB2	oncoprotein	28	0.302	134.687	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Death (PF00531, IPR000488, SM00005): Death domain RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
79	NFKBIA	oncoprotein	31	0.305	172.385	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
80	NFKBIB	interactor	15	0.571	14.813	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
81	NFKBIE	oncoprotein	10	0.711	3.667	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
82	NFKBIZ	interactor	3	1.000	0	PD-C2-AF1 (PF09310, IPR015389): POU domain, class 2, associating factor 1 Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
83	NKRF	interactor	6	0.600	1.751	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif G-patch (PF01585, IPR000467, SM00443): G-patch domain R3H (PF01424, IPR001374, SM00393): R3H domain XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
84	NOTCH1	suppressor	11	0.578	8.269	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
85	NOV	suppressor	3	1.000	0	Cys_knot (PF00007, IPR006208): Cystine-knot domain VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
86	NR3C1	protein found in more fusions	26	0.357	99.785	GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
87	NR4A1	suppressor	15	0.514	22.100	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
88	PARP1	suppressor	20	0.351	50.499	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
89	PCBD1	interactor	8	1.000	0	Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
90	PELP1	interactor	6	0.600	1.530	RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis NUC202 (PF08166, IPR012980): NUC202 domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
91	PHF10	interactor	2	1.000	0	Herpes_MCP (PF03122, IPR000912): Herpes virus major capsid protein PHD (PF00628, IPR019787, SM00249): PHD-finger MRI (PF15325, IPR028278): Modulator of retrovirus infection
92	PLD3	interactor	1	0	0	PLDc_2 (PF13091, IPR025202): PLD-like domain PLDc_3 (PF13918, IPR032803): PLD-like domain
93	PML	suppressor	22	0.448	43.471	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
94	POLR2A	protein found in more fusions	12	0.436	16.151	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
95	PPARG	suppressor	32	0.357	130.075	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
96	PPARGC1A	interactor	11	0.673	5.822	Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
97	PPME1	protein found in more fusions	3	1.000	0	Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
98	PPP4C	interactor	8	0.464	8.173	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
99	PSMA4	interactor	3	1.000	0	Proteasome (PF00227, IPR001353): Proteasome subunit U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34 Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
100	PSMD10	interactor	4	0.833	0.167	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
101	REL	oncoprotein	25	0.303	110.376	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
102	RELA	oncoprotein	77	0.132	1851.576	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
103	RELB	oncoprotein	17	0.434	45.547	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain RelB_leu_zip (PF16180, IPR032399): RelB leucine zipper RelB_transactiv (PF16181, IPR032400): RelB transactivation domain
104	RGS14	interactor	2	1.000	0	GoLoco (PF02188, IPR003109, SM00390): GoLoco motif RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain RGS12_us1 (PF16613): Unstructured region of RGS12
105	RNF123	interactor	1	0	0	SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
106	RPS3	interactor	14	0.495	16.354	KH_2 (PF07650, IPR004044): KH domain Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
107	RPS6KA5	interactor	5	0.900	0.182	Choline_kinase (PF01633): Choline/ethanolamine kinase Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
108	RSF1	oncoprotein	3	0.667	0.500	DDT (PF02791, IPR004022, SM00571): DDT domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) PHD (PF00628, IPR019787, SM00249): PHD-finger UPF0239 (PF06783, IPR009621): Uncharacterised protein family (UPF0239) TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
109	RUVBL2	oncoprotein	16	0.400	25.928	TIP49 (PF06068, IPR010339): TIP49 C-terminus
110	RXRA	oncoprotein	26	0.417	69.982	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
111	SERPINA3	interactor	1	0	0	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
112	SF1	protein found in more fusions	9	0.464	6.275	UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
113	SMAD4	suppressor	15	0.527	12.426	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
114	SOCS3	suppressor	7	0.571	5.169	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
115	SP1	protein found in more fusions	29	0.378	113.400	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
116	SPAG9	interactor	2	1.000	0	DUF501 (PF04417, IPR007511): Protein of unknown function (DUF501) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IncA (PF04156, IPR007285): IncA protein Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
117	SPPL2A	interactor	1	0	0	PA (PF02225, IPR003137): PA domain Peptidase_A22B (PF04258, IPR007369): Signal peptide peptidase
118	SRF	interactor	16	0.467	20.149	SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
119	STAT3	suppressor	20	0.433	44.654	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
120	STAT5A	suppressor	7	0.800	0.794	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
121	STAT6	oncoprotein	6	0.867	0.429	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT6_C (PF14596, IPR028187): STAT6 C-terminal
122	TAB2	oncoprotein	11	0.489	7.870	CUE (PF02845, IPR003892, SM00546): CUE domain DivIC (PF04977, IPR007060): Septum formation initiator Mnd1 (PF03962, IPR005647): Mnd1 family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
123	TBK1	interactor	11	0.711	5.976	DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain
124	TFAP2A	suppressor	8	0.679	2.411	TF_AP-2 (PF03299, IPR013854): Transcription factor AP-2 CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1 Peptidase_Prp (PF04327): Cysteine protease Prp
125	TNIP1	interactor	6	0.600	3.133	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) Filament (PF00038, IPR001664): Intermediate filament protein HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) FlxA (PF14282, IPR025577): FlxA-like protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
126	TNIP2	interactor	11	0.655	4.552	PCRF (PF03462, IPR005139, SM00937): PCRF domain EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55 zf-C2H2_4 (PF13894): C2H2-type zinc finger CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
127	TNIP3	interactor	2	1.000	0	ZapB (PF06005, IPR009252): Cell division protein ZapB ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3 CK2S (PF15011, IPR029159): Casein Kinase 2 substrate zf-C2H2_9 (PF16293, IPR032553): C2H2 type zinc-finger (1 copy) CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
128	TP53BP1	suppressor	10	0.311	19.992	53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
129	TP63	suppressor	13	0.470	13.745	Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
130	TRIP4	interactor	9	0.722	2.908	ASCH (PF04266, IPR007374, SM01022): ASCH domain UxaC (PF02614, IPR003766): Glucuronate isomerase zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
131	TSC22D3	protein found in more fusions	5	0.667	0.472	TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
132	TXN	oncoprotein	6	0.800	1.352	Thioredoxin (PF00085, IPR013766): Thioredoxin
133	UNC5CL	interactor	2	1.000	0	Death (PF00531, IPR000488, SM00005): Death domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain UPA (PF17217): UPA domain
134	VCP	protein found in more fusions	22	0.333	78.300	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
135	VPS26A	protein found in more fusions	2	0	0	Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
136	XPO1	interactor	36	0.214	297.389	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
137	XRCC4	interactor	2	0	0	XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
138	YWHAQ	interactor	13	0.359	24.804	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
139	YY1	protein found in more fusions	16	0.410	23.872	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
140	ZBTB9	interactor	4	0.667	0.452	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type PRIMA1 (PF16101): Proline-rich membrane anchor 1
141	ZFP36	suppressor	7	0.476	4.532	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	NFKB1	parental protein	Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain

B a c k t o T o p ⇑

Fusion ID: Protein names:	CA313276
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Statistics and Network structure information

List of the fusions

List of active interactors

List of missing interactors