1 |
CA313276 | chimera | 140 | 0.080 | 11734.095 | Death (PF00531, IPR000488, SM00005): Death domain Myco_arth_vir_N (PF09610, IPR011732): Mycoplasma virulence signal region (Myco_arth_vir_N) RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
2 |
ABCC2 | interactor | 1 | 0 | 0 | ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter DUF805 (PF05656, IPR008523): Protein of unknown function (DUF805) DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain |
3 |
ANXA4 | interactor | 1 | 0 | 0 | Annexin (PF00191, IPR018502, SM00335): Annexin |
4 |
AURKA | oncoprotein | 17 | 0.442 | 22.734 | Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding |
5 |
BANP | suppressor | 7 | 0.867 | 0.368 | DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845) BEN (PF10523, IPR018379, SM01025): BEN domain |
6 |
BCL3 | oncoprotein | 15 | 0.457 | 18.683 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) |
7 |
BIRC3 | oncoprotein | 8 | 0.476 | 3.922 | BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
8 |
BRMS1 | suppressor | 12 | 0.527 | 6.641 | Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family Sds3 (PF08598, IPR013907): Sds3-like |
9 |
BTRC | oncoprotein | 27 | 0.363 | 96.435 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like |
10 |
CARM1 | oncoprotein | 13 | 0.462 | 17.113 | K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal |
11 |
CD82 | suppressor | 1 | 0 | 0 | Tetraspannin (PF00335, IPR018499): Tetraspanin family |
12 |
CEBPB | oncoprotein | 18 | 0.515 | 22.552 | RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
13 |
CHUK | suppressor | 22 | 0.462 | 40.272 | Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain |
14 |
CLU | suppressor | 8 | 0.619 | 2.570 | Clusterin (PF01093, IPR000753): Clusterin |
15 |
COMMD1 | protein found in more fusions | 23 | 0.359 | 94.447 | COMMD1_N (PF17221): COMMD1 N-terminal domain COMM_domain (PF07258): COMM domain |
16 |
COMMD10 | interactor | 10 | 0.867 | 1.833 | BPL_N (PF09825, IPR019197): Biotin-protein ligase, N terminal COMM_domain (PF07258): COMM domain |
17 |
COMMD2 | interactor | 10 | 0.844 | 2.767 | COMM_domain (PF07258): COMM domain |
18 |
COMMD3 | interactor | 9 | 0.778 | 3.300 | COMM_domain (PF07258): COMM domain |
19 |
COMMD4 | interactor | 11 | 0.782 | 4.633 | COMM_domain (PF07258): COMM domain |
20 |
COMMD5 | interactor | 9 | 0.944 | 0.500 | COMM_domain (PF07258): COMM domain |
21 |
COMMD6 | protein found in more fusions | 10 | 0.556 | 10.250 | COMM_domain (PF07258): COMM domain |
22 |
COMMD8 | interactor | 10 | 0.800 | 4.476 | COMM_domain (PF07258): COMM domain |
23 |
COMMD9 | interactor | 5 | 0.800 | 0.583 | COR (PF16095, IPR032171): C-terminal of Roc, COR, domain CDT1_C (PF16679, IPR032054): DNA replication factor Cdt1 C-terminal domain COMM_domain (PF07258): COMM domain |
24 |
COPB2 | interactor | 5 | 0.667 | 0.422 | Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
25 |
COPS5 | protein found in more fusions | 30 | 0.251 | 175.112 | JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease |
26 |
COPS6 | interactor | 16 | 0.429 | 37.441 | DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function |
27 |
CTNNB1 | oncoprotein | 29 | 0.313 | 121.428 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat |
28 |
CUL3 | protein found in more fusions | 30 | 0.246 | 192.256 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
29 |
CUL4A | protein found in more fusions | 16 | 0.600 | 14.830 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
30 |
CUL4B | oncoprotein | 15 | 0.524 | 23.844 | Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor |
31 |
CUL5 | suppressor | 17 | 0.500 | 31.780 | Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
32 |
DCUN1D1 | interactor | 12 | 0.682 | 9.943 | Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain |
33 |
DNMT3L | interactor | 9 | 0.500 | 5.832 | CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain |
34 |
DPF1 | interactor | 2 | 1.000 | 0 | PHD (PF00628, IPR019787, SM00249): PHD-finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. PHD_4 (PF16866, IPR019787): PHD-finger |
35 |
DPF2 | interactor | 8 | 0.536 | 5.918 | PHD (PF00628, IPR019787, SM00249): PHD-finger zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal Zf_RING (PF16744, IPR031946): KIAA1045 RING finger |
36 |
DPF3 | interactor | 2 | 1.000 | 0 | PHD (PF00628, IPR019787, SM00249): PHD-finger zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. Lar_restr_allev (PF14354): Restriction alleviation protein Lar |
37 |
E2F1 | suppressor | 15 | 0.390 | 28.498 | Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain |
38 |
ECSIT | interactor | 3 | 1.000 | 0 | ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein |
39 |
ELF1 | interactor | 4 | 0.833 | 0.667 | Ets (PF00178, IPR000418, SM00413): Ets-domain PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region Elf-1_N (PF12310, IPR022084): Transcription factor protein N terminal |
40 |
ELF3 | oncoprotein | 5 | 1.000 | 0 | AT_hook (PF02178, IPR017956, SM00384): AT hook motif Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain |
41 |
EP300 | oncoprotein | 50 | 0.221 | 506.749 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type |
42 |
ETS1 | oncoprotein | 7 | 0.667 | 2.241 | Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain |
43 |
FBXW11 | interactor | 11 | 0.644 | 4.144 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like |
44 |
GLUL | protein found in more fusions | 2 | 0 | 0 | Gln-synt_C (PF00120, IPR008146): Glutamine synthetase, catalytic domain Gln-synt_N (PF03951, IPR008147): Glutamine synthetase, beta-Grasp domain |
45 |
GSK3B | suppressor | 23 | 0.299 | 72.023 | Pkinase (PF00069, IPR000719): Protein kinase domain |
46 |
HDAC1 | suppressor | 36 | 0.276 | 227.264 | FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
47 |
HDAC2 | suppressor | 23 | 0.320 | 76.275 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1 |
48 |
HDAC3 | suppressor | 27 | 0.363 | 86.557 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
49 |
HDAC4 | oncoprotein | 19 | 0.392 | 37.690 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
50 |
HDAC5 | protein found in more fusions | 22 | 0.362 | 63.275 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
51 |
HIF1AN | protein found in more fusions | 8 | 0.667 | 1.708 | Cupin_8 (PF13621): Cupin-like domain |
52 |
HMGA1 | oncoprotein | 9 | 0.528 | 8.694 | AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239) |
53 |
HMGA2 | oncoprotein | 2 | 1.000 | 0 | AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF1639 (PF07797, IPR012438): Protein of unknown function (DUF1639) |
54 |
HMGB1 | oncoprotein | 4 | 0.667 | 0.583 | HMG_box_2 (PF09011, IPR009071): HMG-box domain NOA36 (PF06524, IPR010531): NOA36 protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box |
55 |
HSP90AB1 | oncoprotein | 17 | 0.408 | 33.210 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
56 |
HSPA1L | interactor | 12 | 0.545 | 14.045 | HSP70 (PF00012, IPR013126): Hsp70 protein |
57 |
HSPA4 | interactor | 24 | 0.301 | 92.623 | Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5 |
58 |
IKBKB | protein found in more fusions | 19 | 0.431 | 33.808 | FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain |
59 |
IKBKG | interactor | 21 | 0.368 | 52.513 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
60 |
IRF2 | interactor | 4 | 0.833 | 0.500 | IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor |
61 |
IRF8 | suppressor | 6 | 0.600 | 2.077 | IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3 |
62 |
IRF9 | interactor | 2 | 1.000 | 0 | IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3 |
63 |
ITGB3BP | interactor | 4 | 1.000 | 0 | CENP-R (PF06729, IPR009601): Kinetochore component, CENP-R |
64 |
KAT5 | suppressor | 16 | 0.514 | 17.672 | MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain |
65 |
KLF5 | suppressor | 14 | 0.582 | 8.577 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
66 |
KPNA3 | interactor | 4 | 0.500 | 1.083 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat |
67 |
LYL1 | oncoprotein | 2 | 1.000 | 0 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain |
68 |
MAP3K8 | suppressor | 8 | 0.821 | 1.832 | Pkinase (PF00069, IPR000719): Protein kinase domain IML1 (PF12257, IPR027244): Vacuolar membrane-associated protein Iml1 |
69 |
MEN1 | suppressor | 8 | 0.571 | 3.489 | Menin (PF05053, IPR007747): Menin |
70 |
MPP6 | interactor | 1 | 0 | 0 | L27 (PF02828, IPR014775, SM00569): L27 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase |
71 |
MTPN | interactor | 3 | 1.000 | 0 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
72 |
MXD3 | interactor | 1 | 0 | 0 | Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain HTH_20 (PF12840, IPR011991): Helix-turn-helix domain |
73 |
NCOA1 | oncoprotein | 23 | 0.351 | 74.673 | DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein |
74 |
NCOA3 | oncoprotein | 22 | 0.381 | 63.421 | DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3 |
75 |
NCOA6 | oncoprotein | 13 | 0.667 | 6.073 | DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Presenilin (PF01080, IPR001108): Presenilin DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region NST1 (PF13945, IPR025279): Salt tolerance down-regulator |
76 |
NCOR1 | oncoprotein | 21 | 0.448 | 41.305 | BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region |
77 |
NCOR2 | oncoprotein | 30 | 0.386 | 104.902 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820) |
78 |
NFKB2 | oncoprotein | 28 | 0.302 | 134.687 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Death (PF00531, IPR000488, SM00005): Death domain RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
79 |
NFKBIA | oncoprotein | 31 | 0.305 | 172.385 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
80 |
NFKBIB | interactor | 15 | 0.571 | 14.813 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
81 |
NFKBIE | oncoprotein | 10 | 0.711 | 3.667 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
82 |
NFKBIZ | interactor | 3 | 1.000 | 0 | PD-C2-AF1 (PF09310, IPR015389): POU domain, class 2, associating factor 1 Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) |
83 |
NKRF | interactor | 6 | 0.600 | 1.751 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif G-patch (PF01585, IPR000467, SM00443): G-patch domain R3H (PF01424, IPR001374, SM00393): R3H domain XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD |
84 |
NOTCH1 | suppressor | 11 | 0.578 | 8.269 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
85 |
NOV | suppressor | 3 | 1.000 | 0 | Cys_knot (PF00007, IPR006208): Cystine-knot domain VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein |
86 |
NR3C1 | protein found in more fusions | 26 | 0.357 | 99.785 | GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
87 |
NR4A1 | suppressor | 15 | 0.514 | 22.100 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
88 |
PARP1 | suppressor | 20 | 0.351 | 50.499 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region |
89 |
PCBD1 | interactor | 8 | 1.000 | 0 | Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase |
90 |
PELP1 | interactor | 6 | 0.600 | 1.530 | RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis NUC202 (PF08166, IPR012980): NUC202 domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) |
91 |
PHF10 | interactor | 2 | 1.000 | 0 | Herpes_MCP (PF03122, IPR000912): Herpes virus major capsid protein PHD (PF00628, IPR019787, SM00249): PHD-finger MRI (PF15325, IPR028278): Modulator of retrovirus infection |
92 |
PLD3 | interactor | 1 | 0 | 0 | PLDc_2 (PF13091, IPR025202): PLD-like domain PLDc_3 (PF13918, IPR032803): PLD-like domain |
93 |
PML | suppressor | 22 | 0.448 | 43.471 | zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
94 |
POLR2A | protein found in more fusions | 12 | 0.436 | 16.151 | RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat |
95 |
PPARG | suppressor | 32 | 0.357 | 130.075 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region |
96 |
PPARGC1A | interactor | 11 | 0.673 | 5.822 | Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1 |
97 |
PPME1 | protein found in more fusions | 3 | 1.000 | 0 | Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family |
98 |
PPP4C | interactor | 8 | 0.464 | 8.173 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
99 |
PSMA4 | interactor | 3 | 1.000 | 0 | Proteasome (PF00227, IPR001353): Proteasome subunit U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34 Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
100 |
PSMD10 | interactor | 4 | 0.833 | 0.167 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) |
101 |
REL | oncoprotein | 25 | 0.303 | 110.376 | RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
102 |
RELA | oncoprotein | 77 | 0.132 | 1851.576 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
103 |
RELB | oncoprotein | 17 | 0.434 | 45.547 | RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain RelB_leu_zip (PF16180, IPR032399): RelB leucine zipper RelB_transactiv (PF16181, IPR032400): RelB transactivation domain |
104 |
RGS14 | interactor | 2 | 1.000 | 0 | GoLoco (PF02188, IPR003109, SM00390): GoLoco motif RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain RGS12_us1 (PF16613): Unstructured region of RGS12 |
105 |
RNF123 | interactor | 1 | 0 | 0 | SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
106 |
RPS3 | interactor | 14 | 0.495 | 16.354 | KH_2 (PF07650, IPR004044): KH domain Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain |
107 |
RPS6KA5 | interactor | 5 | 0.900 | 0.182 | Choline_kinase (PF01633): Choline/ethanolamine kinase Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
108 |
RSF1 | oncoprotein | 3 | 0.667 | 0.500 | DDT (PF02791, IPR004022, SM00571): DDT domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) PHD (PF00628, IPR019787, SM00249): PHD-finger UPF0239 (PF06783, IPR009621): Uncharacterised protein family (UPF0239) TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1 |
109 |
RUVBL2 | oncoprotein | 16 | 0.400 | 25.928 | TIP49 (PF06068, IPR010339): TIP49 C-terminus |
110 |
RXRA | oncoprotein | 26 | 0.417 | 69.982 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1 |
111 |
SERPINA3 | interactor | 1 | 0 | 0 | Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor) |
112 |
SF1 | protein found in more fusions | 9 | 0.464 | 6.275 | UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain |
113 |
SMAD4 | suppressor | 15 | 0.527 | 12.426 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
114 |
SOCS3 | suppressor | 7 | 0.571 | 5.169 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box |
115 |
SP1 | protein found in more fusions | 29 | 0.378 | 113.400 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
116 |
SPAG9 | interactor | 2 | 1.000 | 0 | DUF501 (PF04417, IPR007511): Protein of unknown function (DUF501) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IncA (PF04156, IPR007285): IncA protein Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II |
117 |
SPPL2A | interactor | 1 | 0 | 0 | PA (PF02225, IPR003137): PA domain Peptidase_A22B (PF04258, IPR007369): Signal peptide peptidase |
118 |
SRF | interactor | 16 | 0.467 | 20.149 | SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) |
119 |
STAT3 | suppressor | 20 | 0.433 | 44.654 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain |
120 |
STAT5A | suppressor | 7 | 0.800 | 0.794 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain |
121 |
STAT6 | oncoprotein | 6 | 0.867 | 0.429 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT6_C (PF14596, IPR028187): STAT6 C-terminal |
122 |
TAB2 | oncoprotein | 11 | 0.489 | 7.870 | CUE (PF02845, IPR003892, SM00546): CUE domain DivIC (PF04977, IPR007060): Septum formation initiator Mnd1 (PF03962, IPR005647): Mnd1 family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others |
123 |
TBK1 | interactor | 11 | 0.711 | 5.976 | DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain |
124 |
TFAP2A | suppressor | 8 | 0.679 | 2.411 | TF_AP-2 (PF03299, IPR013854): Transcription factor AP-2 CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1 Peptidase_Prp (PF04327): Cysteine protease Prp |
125 |
TNIP1 | interactor | 6 | 0.600 | 3.133 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) Filament (PF00038, IPR001664): Intermediate filament protein HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) FlxA (PF14282, IPR025577): FlxA-like protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
126 |
TNIP2 | interactor | 11 | 0.655 | 4.552 | PCRF (PF03462, IPR005139, SM00937): PCRF domain EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55 zf-C2H2_4 (PF13894): C2H2-type zinc finger CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase |
127 |
TNIP3 | interactor | 2 | 1.000 | 0 | ZapB (PF06005, IPR009252): Cell division protein ZapB ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3 CK2S (PF15011, IPR029159): Casein Kinase 2 substrate zf-C2H2_9 (PF16293, IPR032553): C2H2 type zinc-finger (1 copy) CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
128 |
TP53BP1 | suppressor | 10 | 0.311 | 19.992 | 53-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
129 |
TP63 | suppressor | 13 | 0.470 | 13.745 | Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
130 |
TRIP4 | interactor | 9 | 0.722 | 2.908 | ASCH (PF04266, IPR007374, SM01022): ASCH domain UxaC (PF02614, IPR003766): Glucuronate isomerase zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type |
131 |
TSC22D3 | protein found in more fusions | 5 | 0.667 | 0.472 | TSC22 (PF01166, IPR000580): TSC-22/dip/bun family |
132 |
TXN | oncoprotein | 6 | 0.800 | 1.352 | Thioredoxin (PF00085, IPR013766): Thioredoxin |
133 |
UNC5CL | interactor | 2 | 1.000 | 0 | Death (PF00531, IPR000488, SM00005): Death domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain UPA (PF17217): UPA domain |
134 |
VCP | protein found in more fusions | 22 | 0.333 | 78.300 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944) |
135 |
VPS26A | protein found in more fusions | 2 | 0 | 0 | Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26 |
136 |
XPO1 | interactor | 36 | 0.214 | 297.389 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
137 |
XRCC4 | interactor | 2 | 0 | 0 | XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4 |
138 |
YWHAQ | interactor | 13 | 0.359 | 24.804 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
139 |
YY1 | protein found in more fusions | 16 | 0.410 | 23.872 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail |
140 |
ZBTB9 | interactor | 4 | 0.667 | 0.452 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
141 |
ZFP36 | suppressor | 7 | 0.476 | 4.532 | zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) |