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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: CA309051 is the fusion of parental proteins MT1X, RNF216 (from a repository: Thu Dec 15 19:39:59 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins7 (36.84 %)
The number (and %) of the tumor suppressors2 (10.53 %)
Total number of binary PPIs (saturation %)45 (26.32 %)
The number (and %) of affected PPIs18 (40.00 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.684
Assortativity coefficient-0.5319
The network average Clustering coefficient0.564
The number (and %) of a zero Clustering coefficients5 (26.32 %)
The number (and %) of a zero Betweenness Centrality12 (63.16 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MT1X,RNF216 All fusions
: CA309051;
Proteins found in more fusions RIPK1 (see 1 fusions); RNF11 (see 1 fusions); TICAM1 (see 1 fusions); TERF2IP (see 1 fusions); UBE2H (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CA309051chimera180.111245.667DUF226 (PF02890, IPR004180): Borrelia family of unknown function DUF226
Metallothio (PF00131, IPR003019): Metallothionein
2 ARCinteractor100DUF842 (PF05811, IPR008560): Eukaryotic protein of unknown function (DUF842)
Retrotrans_gag (PF03732, IPR005162): Retrotransposon gag protein
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
3 BECN1suppressor40.6671.000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
4 BRCA1suppressor31.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
5 KIR2DL4interactor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
SVM_signal (PF12113, IPR021970): SVM protein signal sequence
6 MOV10interactor100AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
7 NXF1interactor31.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
8 RIPK1protein found in more fusions70.6005.333Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
9 RNF11protein found in more fusions31.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
10 TERF2IPprotein found in more fusions31.0000BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
11 TICAM1protein found in more fusions70.6673.667Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
TIR_2 (PF13676, IPR000157): TIR domain
12 TIRAPinteractor31.0000TIR_2 (PF13676, IPR000157): TIR domain
13 TLR3interactor41.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
14 TLR4interactor40.6672.000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
15 TLR5interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
16 TLR9interactor21.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
17 TRAF3oncoprotein70.6005.333ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
18 UBE2Hprotein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
19 XPO1interactor60.4009.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2 MT1Xparental proteinRib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
3 POT1interactorPOT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
4 RNF216parental proteinDUF226 (PF02890, IPR004180): Borrelia family of unknown function DUF226
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
DUF4645 (PF15488, IPR027891): Domain of unknown function (DUF4645)
5 TERF1interactorTRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
6 UBE2ConcoproteinUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
7 UBE2L3interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
8 UBE2L6interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
9 VKORC1interactorVKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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