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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BY796221 is the fusion of parental proteins ERLIN1 (from a repository: Wed Jun 26 05:07:55 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins7 (26.92 %)
The number (and %) of the tumor suppressors3 (11.54 %)
Total number of binary PPIs (saturation %)91 (28.00 %)
The number (and %) of affected PPIs25 (27.47 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI6.231
Assortativity coefficient-0.3565
The network average Clustering coefficient0.665
The number (and %) of a zero Clustering coefficients1 (3.85 %)
The number (and %) of a zero Betweenness Centrality10 (38.46 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ERLIN1 All fusions
: BY796221;
Proteins found in more fusions CUL7 (see 2 fusions); UBC (see 4 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BY796221chimera250.187316.200Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
2 ADRA1Dinteractor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
3 AMFRoncoprotein120.47317.867CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4 ASB11interactor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
5 CFTRsuppressor41.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
6 CHCHD6interactor50.5002.233CHCH (PF06747, IPR010625): CHCH domain
DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
7 CUL7protein found in more fusions50.5002.000ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
8 DBN1oncoprotein40.5002.500Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
9 ERLIN2interactor180.28884.733Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
10 FAF2interactor100.6117.467DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
11 FBXO6interactor50.6002.733FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
12 GOLT1Binteractor50.8000.800Got1 (PF04178, IPR007305): Got1/Sft2-like family
13 INSIG1interactor70.6672.800INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
14 ITPR1interactor31.0000Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
15 MYEF2interactor30.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
16 NTRK1oncoprotein80.4768.800I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
17 PKN2interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
18 RAB7Asuppressor60.5334.133Ras (PF00071, IPR001806, SM00173): Ras family
19 RNF139oncoprotein31.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
20 RPGRIP1Linteractor21.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FtsL (PF04999, IPR011922): Cell division protein FtsL
T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1
BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4497 (PF14924): Protein of unknown function (DUF4497)
21 SUZ12suppressor31.0000DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
22 SYVN1interactor61.0000Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
23 TMEM63Binteractor31.0000RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
24 UBAC2interactor90.6117.100Rhomboid (PF01694, IPR022764): Rhomboid family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
25 UBCprotein found in more fusions100.44415.367ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
26 VAPAinteractor90.44412.600DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AGR3interactorThioredoxin_7 (PF13899): Thioredoxin-like
2 CHMP2AinteractorSnf7 (PF03357, IPR005024): Snf7
3 CPT1AinteractorCarn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
CPT_N (PF16484, IPR032476): Carnitine O-palmitoyltransferase N-terminus
4 ERLIN1parental proteinRibosomal_L33 (PF00471, IPR001705): Ribosomal protein L33
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
5 FA2HinteractorCyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
FA_hydroxylase (PF04116, IPR006694): Fatty acid hydroxylase superfamily
6 NDUFA12interactorNDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
7 RALYinteractorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
8 SEC22AinteractorLongin (PF13774, IPR010908): Regulated-SNARE-like domain
9 SSR3interactorTRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
10 TMEM199interactorVma12 (PF11712, IPR021013): Endoplasmic reticulum-based factor for assembly of V-ATPase
11 XRCC3oncoproteinRad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain

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