Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BU734913 is the fusion of parental proteins CRYBB2, FAH (from a repository: Thu Oct 17 19:20:17 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins6 (46.15 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)35 (44.87 %)
The number (and %) of affected PPIs12 (34.29 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI4.154
Assortativity coefficient-0.2103
The network average Clustering coefficient0.794
The number (and %) of a zero Clustering coefficients1 (7.69 %)
The number (and %) of a zero Betweenness Centrality9 (69.23 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: FAH,CRYBB2 All fusions
: BU734913;
Proteins found in more fusions HSPB1 (see 4 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BU734913chimera120.22793.000FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
Crystall (PF00030, IPR001064, SM00247): Beta/Gamma crystallin
2 ABATinteractor41.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
3 ADAMTSL4interactor21.0000ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
4 CRYAAoncoprotein51.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
5 CRYABoncoprotein60.7003.000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
6 CRYGCinteractor51.0000Crystall (PF00030, IPR001064, SM00247): Beta/Gamma crystallin
7 EGFRoncoprotein31.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
8 GOT2oncoprotein100Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
9 HSPB1oncoprotein60.7003.000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
10 KRTAP10-8interactor31.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
11 LDHAinteractor51.0000Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
12 PGM1interactor41.0000PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
13 SORDinteractor60.7003.000ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CRYBB2parental proteinCrystall (PF00030, IPR001064, SM00247): Beta/Gamma crystallin
2 FAHparental proteinFAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
3 KRTAP5-9interactorEry_res_leader2 (PF08057, IPR012559): Erythromycin resistance leader peptide
4 MIPinteractorMIP (PF00230, IPR000425): Major intrinsic protein
5 SERTAD1interactorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SERTA (PF06031, IPR009263): SERTA motif
6 TCF4suppressorCDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain

B a c k    t o    T o p ⇑