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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BU734913 is the fusion of parental proteins CRYBB2, FAH (from a repository: Tue May 21 10:41:13 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins6 (46.15 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)35 (44.87 %)
The number (and %) of affected PPIs12 (34.29 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI4.154
Assortativity coefficient-0.2103
The network average Clustering coefficient0.794
The number (and %) of a zero Clustering coefficients1 (7.69 %)
The number (and %) of a zero Betweenness Centrality9 (69.23 %)


List of the fusions

PPI for parental proteins: FAH,CRYBB2 All fusions
: BU734913;
Proteins found in more fusions HSPB1 (see 4 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BU734913chimera120.22793.000FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
Crystall (PF00030, IPR001064, SM00247): Beta/Gamma crystallin
2 ABATinteractor41.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
3 ADAMTSL4interactor21.0000ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
4 CRYAAoncoprotein51.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
5 CRYABoncoprotein60.7003.000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
6 CRYGCinteractor51.0000Crystall (PF00030, IPR001064, SM00247): Beta/Gamma crystallin
7 EGFRoncoprotein31.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
8 GOT2oncoprotein100Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
9 HSPB1oncoprotein60.7003.000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
10 KRTAP10-8interactor31.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
11 LDHAinteractor51.0000Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
12 PGM1interactor41.0000PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
13 SORDinteractor60.7003.000ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CRYBB2parental proteinCrystall (PF00030, IPR001064, SM00247): Beta/Gamma crystallin
2 FAHparental proteinFAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
3 KRTAP5-9interactorEry_res_leader2 (PF08057, IPR012559): Erythromycin resistance leader peptide
4 MIPinteractorMIP (PF00230, IPR000425): Major intrinsic protein
5 SERTAD1interactorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SERTA (PF06031, IPR009263): SERTA motif
6 TCF4suppressorCDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain

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