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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BU680050 is the fusion of parental proteins NDUFAF4 (from a repository: Wed Jan 11 10:29:26 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins4 (11.43 %)
The number (and %) of the tumor suppressors1 (2.86 %)
Total number of binary PPIs (saturation %)169 (28.40 %)
The number (and %) of affected PPIs34 (20.12 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI9.200
Assortativity coefficient-0.3977
The network average Clustering coefficient0.750
The number (and %) of a zero Clustering coefficients1 (2.86 %)
The number (and %) of a zero Betweenness Centrality12 (34.29 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: NDUFAF4 All fusions
: BU680050;
Proteins found in more fusions NDUFS3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BU680050chimera340.226541.902UPF0240 (PF06784, IPR009622): Uncharacterised protein family (UPF0240)
2 ABCE1interactor50.8330.250ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 ACAD9interactor110.8911.501Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 ACIN1interactor30.6670.667Calc_CGRP_IAPP (PF00214, IPR021116): Calcitonin / CGRP / IAPP family
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
FAM27 (PF15832, IPR031672): FAM27 D and E protein family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
RSB_motif (PF16294, IPR032552): RNSP1-SAP18 binding (RSB) motif
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
5 ATP5C1interactor51.0000ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
6 ATP5Einteractor31.0000ATP-synt_Eps (PF04627, IPR006721): Mitochondrial ATP synthase epsilon chain
7 C15orf48interactor190.44450.980B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
8 C1QBPinteractor51.0000MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
9 C2orf47interactor130.56114.687Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
10 CHCHD4interactor21.0000CHCH (PF06747, IPR010625): CHCH domain
Voldacs (PF03517): Regulator of volume decrease after cellular swelling
11 COQ9interactor180.49333.673COQ9 (PF08511, IPR013718): COQ9
12 DHX15interactor40.5002.667DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
AAA_29 (PF13555): P-loop containing region of AAA domain
13 DHX9oncoprotein40.5002.667DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
14 ECSITinteractor130.69713.072ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
15 HNRNPFinteractor30.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
16 HTRA2suppressor31.0000Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32
PDZ_2 (PF13180, IPR001478): PDZ domain
Trypsin_2 (PF13365): Trypsin-like peptidase domain
17 IGF2BP3interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
18 NDUFA13interactor140.70312.859GRIM-19 (PF06212, IPR009346): GRIM-19 protein
19 NDUFA5interactor110.6189.955ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region
20 NDUFAF1interactor81.0000CIA30 (PF08547, IPR013857): Complex I intermediate-associated protein 30 (CIA30)
21 NDUFAF3interactor140.7696.145DUF498 (PF04430, IPR007523): Protein of unknown function (DUF498/DUF598)
22 NDUFB10interactor70.9050.500NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
23 NDUFB5interactor60.9330.200NDUF_B5 (PF09781, IPR019173): NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
24 NDUFS2interactor140.7258.992Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
25 NDUFS3protein found in more fusions260.383115.736Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
26 NDUFS5interactor160.61724.531Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
27 NDUFS7interactor160.66712.729Oxidored_q6 (PF01058, IPR006137): NADH ubiquinone oxidoreductase, 20 Kd subunit
28 NDUFS8interactor100.8891.118Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
Fer4_16 (PF13484): 4Fe-4S double cluster binding domain
29 NUDT19interactor100NUDIX (PF00293, IPR000086): NUDIX domain
30 PITRM1interactor31.0000M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
31 PMPCAinteractor61.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
32 PMPCBinteractor61.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
33 POLDIP2interactor41.0000DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525)
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
34 POU5F1oncoprotein60.9000.222Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
35 TIMMDC1interactor150.66712.282Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BCKDHAinteractorE1_dh (PF00676, IPR001017): Dehydrogenase E1 component
2 ECH1interactorECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
3 NDUFAF4parental proteinUPF0240 (PF06784, IPR009622): Uncharacterised protein family (UPF0240)

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