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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BU608643 is the fusion of parental proteins CHMP2B (from a repository: Tue Apr 25 10:54:18 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)7
The number (and %) of the onco-proteins2 (28.57 %)
The number (and %) of the tumor suppressors1 (14.29 %)
Total number of binary PPIs (saturation %)8 (38.10 %)
The number (and %) of affected PPIs6 (75.00 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI1.714
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients7 (100.00 %)
The number (and %) of a zero Betweenness Centrality6 (85.71 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CHMP2B All fusions
: BU608643;
Proteins found in more fusions PAFAH1B1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BU608643chimera6030.000LEM (PF03020, IPR003887, SM00540): LEM domain
Snf7 (PF03357, IPR005024): Snf7
2 ATP6V1B1interactor100ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
3 MYH14interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
4 PAFAH1B1suppressor200LisH (PF08513, IPR013720, SM00667): LisH
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
5 PNMA1oncoprotein100PNMA (PF14893, IPR026523): PNMA
6 USP8interactor200DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
SET (PF00856, IPR001214, SM00317): SET domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
7 XPO1interactor100CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ATP5C1interactorATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
2 ATP6AP2interactorPhosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
3 CHMP2AinteractorSnf7 (PF03357, IPR005024): Snf7
4 CHMP2Bparental proteinInvolucrin (PF00904, IPR000354): Involucrin repeat
Snf7 (PF03357, IPR005024): Snf7
5 CHMP3interactorSnf7 (PF03357, IPR005024): Snf7
6 CHMP4BinteractorSnf7 (PF03357, IPR005024): Snf7
7 GOLT1BinteractorGot1 (PF04178, IPR007305): Got1/Sft2-like family
8 LTN1interactorzf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
9 MAD2L1oncoproteinHORMA (PF02301, IPR003511): HORMA domain
10 MALSU1interactorRsfS (PF02410, IPR025656): Ribosomal silencing factor during starvation
11 PHGDHinteractor2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
12 RAB5ConcoproteinRas (PF00071, IPR001806, SM00173): Ras family
13 RAB7AsuppressorRas (PF00071, IPR001806, SM00173): Ras family
14 SGO1interactorDUF778 (PF05608, IPR008496): Protein of unknown function (DUF778)
Menin (PF05053, IPR007747): Menin
Shugoshin_C (PF07557, IPR011515): Shugoshin C terminus
Shugoshin_N (PF07558, IPR011516): Shugoshin N-terminal coiled-coil region
15 SQSTM1oncoproteinPB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
16 TERF2IPinteractorBRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
17 TRAF2interactorMATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
18 USP54interactorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
19 VHLsuppressorTrypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain

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