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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BU608568 is the fusion of parental proteins GDPD1, VPS13B (from a repository: Wed Dec 11 18:42:36 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)5
The number (and %) of the onco-proteins2 (40.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)5 (50.00 %)
The number (and %) of affected PPIs4 (80.00 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI1.600
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients5 (100.00 %)
The number (and %) of a zero Betweenness Centrality4 (80.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: VPS13B,GDPD1 All fusions
: BU608568;
Proteins found in more fusions CSNK1E (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BU608568chimera4012.000ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
2 CSNK1Eprotein found in more fusions200APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
3 DNAJC7interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
4 FAM177A1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Connexin (PF00029, IPR013092, SM00037): Connexin
FAM177 (PF14774, IPR028260): FAM177 family
5 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 A1BGinteractorIg_2 (PF13895, IPR007110): Immunoglobulin domain
2 A2MinteractorA2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
3 AHSGinteractorCystatin (PF00031, IPR000010, SM00043): Cystatin domain
4 ALBinteractorSerum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
5 APOA1interactorApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
6 APOA2interactorApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
7 APOA4interactorApo-CIII (PF05778, IPR008403): Apolipoprotein CIII (Apo-CIII)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
ApoLp-III (PF07464, IPR010009): Apolipophorin-III precursor (apoLp-III)
8 C3interactorA2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
NTR (PF01759, IPR018933, SM00206): UNC-6/NTR/C345C module
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
9 C4AinteractorA2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
NTR (PF01759, IPR018933, SM00206): UNC-6/NTR/C345C module
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
10 CFBinteractorVWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
11 CPinteractorCu-oxidase (PF00394, IPR001117): Multicopper oxidase
Cu-oxidase_2 (PF07731, IPR011706): Multicopper oxidase
Cu-oxidase_3 (PF07732, IPR011707): Multicopper oxidase
12 GDPD1parental proteinGDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
13 HBA2interactorGlobin (PF00042, IPR000971): Globin
14 HBBinteractorGlobin (PF00042, IPR000971): Globin
15 HBDinteractorGlobin (PF00042, IPR000971): Globin
16 HPinteractorSushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
17 HPXinteractorHemopexin (PF00045, IPR018487, SM00120): Hemopexin
18 IGHA1interactorig (PF00047, IPR013151, SM00409): Immunoglobulin domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4333 (PF14230, IPR025637): Domain of unknown function (DUF4333)
19 IGHG1oncoproteinC1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
20 IGHG2oncoproteinC1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
21 ITIH2interactorITI_HC_C (PF06668, IPR010600): Inter-alpha-trypsin inhibitor heavy chain C-terminus
VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
DUF4561 (PF15120, IPR027818): Domain of unknown function (DUF4561)
22 KNG1interactorBradykinin (PF06753, IPR009608): Bradykinin
Chorion_2 (PF03964, IPR005649): Chorion family 2
Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
23 ORM1interactorLipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
24 ORM2interactorLipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
25 SERPINA1oncoproteinSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
26 SERPINA3interactorSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
27 TFinteractorTransferrin (PF00405, IPR001156, SM00094): Transferrin
28 TSPAN5interactorTetraspannin (PF00335, IPR018499): Tetraspanin family
29 VPS13Bparental proteinATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal

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