Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	109
The number (and %) of the onco-proteins	33 (30.28 %)
The number (and %) of the tumor suppressors	3 (2.75 %)
Total number of binary PPIs (saturation %)	723 (12.28 %)
The number (and %) of affected PPIs	108 (14.94 %)
The number of possible different fusions	22
PPI diameter	2
PPI radius	1
The average degree of PPI	12.495
Assortativity coefficient	-0.2556
The network average Clustering coefficient	0.552
The number (and %) of a zero Clustering coefficients	5 (4.59 %)
The number (and %) of a zero Betweenness Centrality	19 (17.43 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: RANGAP1	All fusions : BU527948;
Proteins found in more fusions	PTBP1 (see 1 fusions); LMNA (see 3 fusions); EEF1G (see 1 fusions); U2AF2 (see 2 fusions); KPNB1 (see 2 fusions); CUL7 (see 2 fusions); HUWE1 (see 2 fusions); NCOA6 (see 1 fusions); NUP153 (see 2 fusions); PRPF8 (see 3 fusions); EGFR (see 2 fusions); UBR5 (see 4 fusions); CSNK2A1 (see 1 fusions); NLK (see 4 fusions); PRDX6 (see 1 fusions); TPD52L2 (see 2 fusions); MIB1 (see 3 fusions); SENP1 (see 1 fusions); PCGF2 (see 1 fusions); NCL (see 3 fusions); SNW1 (see 1 fusions);

List of the fusions

PPI for parental proteins: RANGAP1

All fusions

: BU527948;

Proteins found in more fusions

PTBP1 (see 1 fusions); LMNA (see 3 fusions); EEF1G (see 1 fusions); U2AF2 (see 2 fusions); KPNB1 (see 2 fusions); CUL7 (see 2 fusions); HUWE1 (see 2 fusions); NCOA6 (see 1 fusions); NUP153 (see 2 fusions); PRPF8 (see 3 fusions); EGFR (see 2 fusions); UBR5 (see 4 fusions); CSNK2A1 (see 1 fusions); NLK (see 4 fusions); PRDX6 (see 1 fusions); TPD52L2 (see 2 fusions); MIB1 (see 3 fusions); SENP1 (see 1 fusions); PCGF2 (see 1 fusions); NCL (see 3 fusions); SNW1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	BU527948	chimera	108	0.099	7063.686	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain SDA1 (PF05285, IPR007949): SDA1 LRR_6 (PF13516, IPR001611): Leucine Rich repeat
2	ACTR2	interactor	29	0.367	137.404	Actin (PF00022, IPR004000, SM00268): Actin
3	ACTR3	interactor	20	0.495	36.662	Actin (PF00022, IPR004000, SM00268): Actin
4	ARPC1B	interactor	14	0.527	19.773	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
5	ARPC2	interactor	17	0.551	24.622	P34-Arc (PF04045, IPR007188): Arp2/3 complex, 34 kD subunit p34-Arc Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
6	ARRB2	interactor	11	0.382	16.933	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7	ATP6AP2	interactor	5	0.500	2.200	Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase Renin_r (PF07850, IPR012493): Renin receptor-like protein
8	BABAM1	interactor	3	1.000	0	VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
9	BAG1	oncoprotein	8	0.679	3.894	BAG (PF02179, IPR003103, SM00264): BAG domain Presenilin (PF01080, IPR001108): Presenilin ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
10	C11orf58	interactor	4	0.500	1.150	DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) SMAP (PF15477, IPR028124): Small acidic protein family
11	CALU	interactor	23	0.451	58.419	EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
12	CCL5	interactor	1	0	0	IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
13	CDC5L	interactor	24	0.427	68.597	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
14	COL4A3BP	interactor	3	1.000	0	Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase PH (PF00169, IPR001849, SM00233): PH domain START (PF01852, IPR002913, SM00234): START domain
15	CPSF1	interactor	9	0.556	6.282	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term HPS3_N (PF14761, IPR029437): Hermansky-Pudlak syndrome 3
16	CPSF4	interactor	4	0.667	0.468	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCHC (PF00098, IPR001878): Zinc knuckle zf-CCCH_3 (PF15663): Zinc-finger containing family
17	CSNK2A1	oncoprotein	16	0.419	29.067	Pkinase (PF00069, IPR000719): Protein kinase domain
18	CUL7	protein found in more fusions	31	0.317	122.635	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
19	DBNL	interactor	4	0.667	0.508	RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
20	DYNC1LI1	interactor	4	0.833	0.286	DLIC (PF05783, IPR022780): Dynein light intermediate chain (DLIC)
21	EEF1G	protein found in more fusions	9	0.536	5.309	EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
22	EEF2K	interactor	8	0.679	3.490	Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
23	EFL1	interactor	13	0.628	9.198	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
24	EFTUD2	interactor	15	0.527	17.939	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
25	EGFR	oncoprotein	20	0.339	59.578	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
26	FOXB1	interactor	7	0.381	6.067	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
27	FOXE1	oncoprotein	3	0.667	0.250	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
28	FOXJ3	interactor	1	0	0	Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1 Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
29	FOXL1	oncoprotein	4	0.833	0.250	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
30	FOXQ1	interactor	8	0.464	7.767	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
31	GNAI1	oncoprotein	2	1.000	0	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
32	GNAI3	interactor	5	0.600	3.111	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
33	GNL1	interactor	3	1.000	0	HbrB (PF08539, IPR013745): HbrB-like MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
34	GTF3C3	interactor	8	0.393	11.424	BUD22 (PF09073, IPR015158): BUD22 PGA2 (PF07543, IPR011431): Protein trafficking PGA2 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1 DUF3369 (PF11849, IPR021800): Domain of unknown function (DUF3369) ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat TPR_20 (PF14561): Tetratricopeptide repeat
35	HUWE1	oncoprotein	18	0.375	46.695	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
36	IPO11	interactor	12	0.470	18.532	DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein HEAT_2 (PF13646): HEAT repeats
37	IPO5	interactor	15	0.524	18.075	HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat AAA_30 (PF13604): AAA domain HEAT_2 (PF13646): HEAT repeats PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
38	JUN	oncoprotein	6	0.500	3.900	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
39	KDM2A	interactor	2	1.000	0	JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain F-box (PF00646, IPR001810, SM00256): F-box domain DZR (PF12773, IPR025874): Double zinc ribbon LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat PHD_4 (PF16866, IPR019787): PHD-finger
40	KIF1BP	interactor	16	0.567	26.738	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat KBP_C (PF12309, IPR022083): KIF-1 binding protein C terminal TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
41	KPNB1	protein found in more fusions	30	0.369	129.261	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat
42	LMNA	protein found in more fusions	16	0.514	20.532	Filament (PF00038, IPR001664): Intermediate filament protein LTD (PF00932, IPR001322): Lamin Tail Domain Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
43	LPP	oncoprotein	13	0.321	29.632	LIM (PF00412, IPR001781, SM00132): LIM domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
44	MEPCE	interactor	8	0.607	3.163	Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
45	MIB1	protein found in more fusions	3	1.000	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat MIB_HERC2 (PF06701, IPR010606): Mib_herc2 ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
46	MMS19	interactor	10	0.378	15.747	DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
47	MYO18A	interactor	5	0.800	0.533	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_tail_1 (PF01576, IPR002928): Myosin tail PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
48	NCL	protein found in more fusions	17	0.508	19.891	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1
49	NCOA6	oncoprotein	3	1.000	0	DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Presenilin (PF01080, IPR001108): Presenilin DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region NST1 (PF13945, IPR025279): Salt tolerance down-regulator
50	NDUFA7	interactor	2	1.000	0	CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
51	NIF3L1	interactor	16	0.638	14.056	NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
52	NLK	protein found in more fusions	4	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
53	NSUN2	interactor	17	0.500	33.132	Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
54	NTRK1	oncoprotein	49	0.158	645.381	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
55	NUP107	interactor	23	0.458	58.128	Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107
56	NUP153	protein found in more fusions	23	0.489	45.244	Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
57	NUP35	interactor	10	0.733	4.286	Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
58	NUP85	interactor	12	0.606	10.406	Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
59	NXF1	interactor	33	0.246	241.537	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
60	OBSL1	interactor	32	0.342	115.948	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
61	OSGEP	interactor	17	0.617	14.658	Peptidase_M22 (PF00814, IPR000905): Glycoprotease family
62	PANK4	interactor	14	0.593	13.480	DUF89 (PF01937, IPR002791): Protein of unknown function DUF89 Fumble (PF03630, IPR004567): Fumble
63	PCF11	interactor	4	0.833	0.111	CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger CFIA_Pcf11 (PF11526, IPR021605): Subunit of cleavage factor IA Pcf11
64	PCGF2	suppressor	5	0.667	0.571	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
65	PMS1	oncoprotein	7	0.600	2.752	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain HTH_Tnp_IS630 (PF01710, IPR002622): Transposase HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box MRP-L46 (PF11788, IPR021757): 39S mitochondrial ribosomal protein L46 HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
66	PNPT1	interactor	8	0.679	2.359	PNPase (PF03726, IPR015848): Polyribonucleotide nucleotidyltransferase, RNA binding domain RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1 RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2 S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain KH_1 (PF00013, IPR004088, SM00322): KH domain
67	POLR3C	interactor	3	0.667	1.000	HTH_9 (PF08221, IPR013197): RNA polymerase III subunit RPC82 helix-turn-helix domain NIT (PF08376, IPR013587): Nitrate and nitrite sensing RNA_pol_Rpc82 (PF05645, IPR008806): RNA polymerase III subunit RPC82 HD_4 (PF13328, IPR003607): HD domain
68	PPIB	interactor	5	0.800	0.170	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
69	PPIF	interactor	1	0	0	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
70	PPP2R5D	interactor	9	0.556	7.303	B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
71	PRDX6	protein found in more fusions	6	0.500	1.954	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
72	PRPF8	oncoprotein	18	0.529	22.061	PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain PROCN (PF08083, IPR012592): PROCN (NUC071) domain PROCT (PF08084, IPR012984): PROCT (NUC072) domain RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8 U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8 U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8 JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
73	PTBP1	oncoprotein	12	0.545	7.267	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
74	RALY	interactor	15	0.476	29.174	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
75	RAN	oncoprotein	17	0.551	24.285	Ras (PF00071, IPR001806, SM00173): Ras family
76	RANBP2	oncoprotein	31	0.368	145.851	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693) IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1 TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
77	RBPJ	interactor	5	0.500	3.404	BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding TIG (PF01833, IPR002909): IPT/TIG domain
78	RCC1	interactor	17	0.456	43.232	RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
79	RGPD2	interactor	1	0	0	GRIP (PF01465, IPR000237, SM00755): GRIP domain HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Tropomyosin (PF00261, IPR000533): Tropomyosin Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat Rab_bind (PF16704, IPR032023): Rab binding domain
80	RGPD5	interactor	3	1.000	0	GRIP (PF01465, IPR000237, SM00755): GRIP domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat FlxA (PF14282, IPR025577): FlxA-like protein TPR_19 (PF14559): Tetratricopeptide repeat Rab_bind (PF16704, IPR032023): Rab binding domain
81	RGPD6	interactor	1	0	0	GRIP (PF01465, IPR000237, SM00755): GRIP domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat FlxA (PF14282, IPR025577): FlxA-like protein TPR_19 (PF14559): Tetratricopeptide repeat Rab_bind (PF16704, IPR032023): Rab binding domain
82	RNF2	interactor	20	0.316	63.125	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
83	RPRD1B	interactor	14	0.451	26.569	CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. Efg1 (PF10153, IPR019310): rRNA-processing protein Efg1 CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3 CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
84	SAE1	interactor	11	0.491	13.178	ThiF (PF00899, IPR000594): ThiF family
85	SEH1L	interactor	12	0.758	3.865	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
86	SENP1	protein found in more fusions	9	0.714	3.319	Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
87	SENP2	interactor	4	1.000	0	Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
88	SH3GLB1	suppressor	15	0.615	14.395	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
89	SIRT7	interactor	25	0.347	80.975	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
90	SNW1	protein found in more fusions	27	0.360	119.041	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
91	SORD	interactor	3	1.000	0	ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
92	SOX2	oncoprotein	13	0.303	24.624	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOXp (PF12336, IPR022097): SOX transcription factor
93	SUB1	interactor	7	0.467	5.238	Dehydrin (PF00257, IPR000167): Dehydrin PC4 (PF02229, IPR003173): Transcriptional Coactivator p15 (PC4)
94	SUMO1	interactor	20	0.351	74.124	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
95	SUPT5H	interactor	13	0.462	17.121	KOW (PF00467, IPR005824, SM00739): KOW motif Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
96	THG1L	interactor	10	0.750	2.609	Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase Thg1C (PF14413, IPR025845): Thg1 C terminal domain
97	TMUB1	interactor	2	1.000	0	DUF347 (PF03988, IPR007136): Repeat of Unknown Function (DUF347) ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF4227 (PF14004, IPR025321): Protein of unknown function (DUF4227)
98	TOPORS	suppressor	3	1.000	0	Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
99	TP53RK	oncoprotein	17	0.610	17.466	APH (PF01636, IPR002575): Phosphotransferase enzyme family Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
100	TPD52L2	protein found in more fusions	19	0.510	30.068	TPD52 (PF04201, IPR007327): Tumour protein D52 family
101	TPRKB	interactor	16	0.583	21.748	CGI-121 (PF08617, IPR013926): Kinase binding protein CGI-121
102	U2AF2	protein found in more fusions	19	0.549	23.414	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
103	UBE2E3	interactor	5	0.500	1.733	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
104	UBE2I	interactor	23	0.338	102.097	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
105	UBR4	interactor	6	0.400	3.055	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Pheromone (PF08015, IPR012597): Fungal mating-type pheromone RecR (PF02132, IPR023628): RecR protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) DZR (PF12773, IPR025874): Double zinc ribbon E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4 FAM176 (PF14851): FAM176 family
106	UBR5	protein found in more fusions	9	0.393	9.453	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SDA1 (PF05285, IPR007949): SDA1 HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
107	UFM1	interactor	9	0.667	8.155	Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
108	USPL1	interactor	4	0.500	1.222	zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain Peptidase_C98 (PF15499, IPR028890): Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF4650 (PF15509, IPR029388): Domain of unknown function (DUF4650)
109	XPO1	interactor	31	0.252	205.987	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	RANGAP1	parental protein	RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain SDA1 (PF05285, IPR007949): SDA1 LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
2	SCARNA22	interactor	NA

B a c k t o T o p ⇑

Fusion ID: Protein names:	BU527948
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List of the fusions

List of active interactors

List of missing interactors