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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)88
The number (and %) of the onco-proteins16 (18.18 %)
The number (and %) of the tumor suppressors8 (9.09 %)
Total number of binary PPIs (saturation %)321 (8.39 %)
The number (and %) of affected PPIs87 (27.10 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI6.750
Assortativity coefficient-0.3418
The network average Clustering coefficient0.576
The number (and %) of a zero Clustering coefficients12 (13.64 %)
The number (and %) of a zero Betweenness Centrality30 (34.09 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: VPS26A All fusions
: BU507793;
Proteins found in more fusions PSMC2 (see 1 fusions); UBQLN1 (see 2 fusions); AHCYL1 (see 3 fusions); MCM7 (see 2 fusions); SNX1 (see 1 fusions); NFKB1 (see 2 fusions); USP1 (see 1 fusions); VPS35 (see 2 fusions); STAT1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BU507793chimera870.0565643.887Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
2 AHCYL1suppressor70.6673.067AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
3 ANKFY1interactor60.6672.800Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
4 ANKRD27interactor21.0000TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
Ribonuc_red_sm (PF00268, IPR000358): Ribonucleotide reductase, small chain
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
5 ATP6V1Finteractor70.4769.333ATP-synt_F (PF01990, IPR008218): ATP synthase (F/14-kDa) subunit
6 BAG6interactor80.28610.833DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
7 BCS1Linteractor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
BCS1_N (PF08740, IPR014851, SM01024): BCS1 N terminal
AAA_25 (PF13481): AAA domain
8 BHLHE41suppressor200Adeno_PIX (PF03955, IPR005641): Adenovirus hexon-associated protein (IX)
Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
9 CAPZBinteractor40.5001.333Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit
10 CD99L2interactor21.0000CD99L2 (PF12301, IPR022078): CD99 antigen like protein 2
11 CELF1interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
12 CORO1Binteractor70.6674.067DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_4 (PF16300): Type of WD40 repeat
13 CORO1Concoprotein110.47320.400DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
WD40_4 (PF16300): Type of WD40 repeat
14 COX6B1interactor200COX6B (PF02297, IPR003213): Cytochrome oxidase c subunit VIb
15 CPSF6interactor40.5001.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
16 CRTAPinteractor21.0000Whi5 (PF08528, IPR013734): Whi5 like
YfiO (PF13525): Outer membrane lipoprotein
Stomagen (PF16851, IPR031753): Stomagen
17 CYHR1interactor70.4767.833Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
18 DDI2interactor50.5003.333Asp_protease (PF09668, IPR019103): Aspartyl protease
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
19 DNM1Linteractor110.37821.300Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
AAA_16 (PF13191): AAA ATPase domain
20 EHD1interactor41.0000Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
21 ERCC4oncoprotein21.0000ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
LUC7 (PF03194, IPR004882): LUC7 N_terminus
T2SSM_b (PF10741, IPR007690): Type II secretion system (T2SS), protein M subtype b
HHH_5 (PF14520): Helix-hairpin-helix domain
22 ETF1interactor50.7001.833eRF1_1 (PF03463, IPR005140): eRF1 domain 1
eRF1_2 (PF03464, IPR005141): eRF1 domain 2
eRF1_3 (PF03465, IPR005142): eRF1 domain 3
23 FAM129Binteractor110.52716.854PH (PF00169, IPR001849, SM00233): PH domain
24 FAM21Ainteractor60.8001.400DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
CAP-ZIP_m (PF15255, IPR029341): WASH complex subunit CAP-Z interacting, central region
25 FAM21Cinteractor50.5003.233DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
CAP-ZIP_m (PF15255, IPR029341): WASH complex subunit CAP-Z interacting, central region
26 FKBP15interactor40.8330.500Filament (PF00038, IPR001664): Intermediate filament protein
FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
WH1 (PF00568, IPR000697, SM00461): WH1 domain
SOSSC (PF15925, IPR031821): SOSS complex subunit C
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
27 FN1oncoprotein150.19063.567fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
28 H1FXinteractor40.6670.900IGPS (PF00218, IPR013798): Indole-3-glycerol phosphate synthase
29 H3F3Aoncoprotein70.8571.233Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
30 HDLBPoncoprotein90.7224.387BMC (PF00936, IPR000249, SM00877): BMC domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
KH_5 (PF13184, IPR025249): NusA-like KH domain
SLS (PF14611, IPR032741): Mitochondrial inner-membrane-bound regulator
DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
31 HIST1H1Einteractor100Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
32 HSPA4Linteractor40.6671.067HSP70 (PF00012, IPR013126): Hsp70 protein
33 INTS7interactor100DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
SPG48 (PF14764, IPR028222): AP-5 complex subunit, vesicle trafficking
34 JMJD6interactor60.6004.333AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
35 KIAA0368interactor50.5002.900HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
36 KIAA1033interactor70.6195.400WASH-7_mid (PF14744, IPR028282): WASH complex subunit 7
WASH-7_N (PF14745, IPR028191): WASH complex subunit 7, N-terminal
WASH-7_C (PF14746, IPR028283): WASH complex subunit 7, C-terminal
37 LCMT2interactor21.0000Kelch_2 (PF07646, IPR011498): Kelch motif
LCM (PF04072, IPR007213): Leucine carboxyl methyltransferase
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
38 MAGEL2interactor21.0000MAGE (PF01454, IPR002190): MAGE family
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
39 MCM7protein found in more fusions70.6671.987MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
40 MIFoncoprotein31.0000MIF (PF01187, IPR001398): Macrophage migration inhibitory factor (MIF)
41 MPDZinteractor100L27_2 (PF09045, IPR015132): L27_2
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
42 MUL1interactor40.6670.333DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
DUF3040 (PF11239, IPR021401): Protein of unknown function (DUF3040)
GIDE (PF12483, IPR022170): E3 Ubiquitin ligase
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
43 NAA10oncoprotein70.5715.321Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
44 NAA15interactor60.6004.333NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
45 NFKB1suppressor200Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
46 NMIinteractor70.4676.667IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
47 NOLC1interactor100DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain
Stm1_N (PF09598, IPR019084): Stm1
stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
PAF (PF15715, IPR031444): PCNA-associated factor
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NuDC (PF16273, IPR032572): Nuclear distribution C domain
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
48 NTRK1oncoprotein420.100669.300I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
49 NUDCinteractor100.60010.354CS (PF04969, IPR007052): CS domain
D5_N (PF08706, IPR014818, SM00885): D5 N terminal like
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc.
NuDC (PF16273, IPR032572): Nuclear distribution C domain
50 P3H1interactor30.6671.000TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
YfiO (PF13525): Outer membrane lipoprotein
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
MCM_N (PF14551, IPR027925): MCM N-terminal domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
51 PSMC2protein found in more fusions50.8330.500AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
52 PSMG3interactor40.6671.667PAC3 (PF10178, IPR018788): Proteasome assembly chaperone 3
53 PTPN23suppressor21.0000BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
SOGA (PF11365, IPR027881): Protein SOGA
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
54 PUM1interactor21.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
YppG (PF14179, IPR025555): YppG-like protein
55 RAI14interactor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Fez1 (PF06818): Fez1
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_13 (PF13166, IPR026866): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
56 RBM26interactor21.0000Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking
PWI (PF01480, IPR002483, SM00311): PWI domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TT_ORF1 (PF02956, IPR004219): TT viral orf 1
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
57 RBM4suppressor30.6670.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
CompInhib_SCIN (PF11546, IPR021612): Staphylococcal complement inhibitor SCIN
58 RIOK2interactor21.0000RIO1 (PF01163, IPR018934): RIO1 family
Rio2_N (PF09202, IPR015285): Rio2, N-terminal
59 RUFY1interactor31.0000DM (PF00751, IPR001275, SM00301): DM DNA binding domain
FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
RUN (PF02759, IPR004012, SM00593): RUN domain
Tektin (PF03148, IPR000435): Tektin family
60 RYKoncoprotein21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
61 SAC3D1interactor51.0000SAC3_GANP (PF03399, IPR005062): SAC3/GANP family
62 SDCCAG3interactor21.0000GA (PF01468, IPR002988, SM00844): GA module
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
63 SEC24Ainteractor80.42910.933Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
64 SNX1protein found in more fusions80.8570.954PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
65 SNX2interactor100.6229.487PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
66 SSSCA1interactor80.5715.233Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
67 STAT1suppressor110.46716.487SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
68 SYMPKinteractor30.6670.167HEAT (PF02985, IPR000357): HEAT repeat
DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453)
Symplekin_C (PF12295, IPR022075): Symplekin tight junction protein C terminal
Cohesin_HEAT (PF12765, IPR026003): HEAT repeat associated with sister chromatid cohesion
69 TARSinteractor70.7142.633HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
70 TBC1D15interactor50.7002.167Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
71 TBC1D5interactor60.8001.221RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
72 THUMPD3interactor31.0000MTS (PF05175, IPR007848): Methyltransferase small domain
THUMP (PF02926, IPR004114, SM00981): THUMP domain
UPF0020 (PF01170, IPR000241): Putative RNA methylase family UPF0020
73 TTC4suppressor90.58311.633TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
74 UBE4Bsuppressor140.43635.421DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
75 UBL4Ainteractor40.5001.567ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
76 UBQLN1protein found in more fusions140.29544.600Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
77 UBQLN4interactor70.5335.400CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
78 UBXN7interactor50.8001.067UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
79 UNKinteractor60.4004.900MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
80 USP1protein found in more fusions40.6671.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
81 UTP4interactor100CPSF_A (PF03178, IPR004871): CPSF A subunit region
PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PQQ_2 (PF13360, IPR002372): PQQ-like domain
82 VPS25interactor61.0000ESCRT-II (PF05871, IPR008570): ESCRT-II complex subunit
83 VPS26Binteractor120.42431.587Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
84 VPS29interactor190.32274.900Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
85 VPS35protein found in more fusions290.201247.854FerA (PF08165, IPR012560): FerA (NUC095) domain
Vps35 (PF03635, IPR005378): Vacuolar protein sorting-associated protein 35
86 VPS36interactor100.58312.633EAP30 (PF04157, IPR007286): EAP30/Vps36 family
Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36
87 VPS4Binteractor60.8001.567AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
88 ZER1interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
HEAT_EZ (PF13513): HEAT-like repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 APEHoncoproteinPeptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
2 C2orf69interactorUPF0565 (PF10561, IPR018881): Uncharacterised protein family UPF0565
3 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
4 FAM102BinteractorNT-C2 (PF10358, IPR019448): N-terminal C2 in EEIG1 and EHBP1 proteins
5 KIAA0196interactorStrumpellin (PF10266, IPR019393): Hereditary spastic paraplegia protein strumpellin
6 RAB7AsuppressorRas (PF00071, IPR001806, SM00173): Ras family
7 UBE2V2interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
8 VPS26Aparental proteinVps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
9 ZPR1interactorzf-ZPR1 (PF03367, IPR004457, SM00709): ZPR1 zinc-finger domain

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