Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BQ937538 is the fusion of parental proteins SPDL1 (from a repository: Thu Feb 2 06:29:37 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins6 (22.22 %)
The number (and %) of the tumor suppressors2 (7.41 %)
Total number of binary PPIs (saturation %)39 (11.11 %)
The number (and %) of affected PPIs26 (66.67 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.222
Assortativity coefficient-0.4249
The network average Clustering coefficient0.247
The number (and %) of a zero Clustering coefficients19 (70.37 %)
The number (and %) of a zero Betweenness Centrality25 (92.59 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SPDL1 All fusions
: BQ937538;
Proteins found in more fusions EWSR1 (see 2 fusions); TRAF4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BQ937538chimera260.012641.000ZapB (PF06005, IPR009252): Cell division protein ZapB
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
DUF2911 (PF11138, IPR021314): Protein of unknown function (DUF2911)
GTA_holin_3TM (PF11351, IPR021497): Holin of 3TMs, for gene-transfer release
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
2 CA8interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
3 CEP126interactor100Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
K1377 (PF15352, IPR028257): Susceptibility to monomelic amyotrophy
4 DHX40interactor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF4685 (PF15737, IPR032756): Domain of unknown function (DUF4685)
5 DYX1C1interactor100CS (PF04969, IPR007052): CS domain
Presenilin (PF01080, IPR001108): Presenilin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
DUF3035 (PF11233, IPR021395): Protein of unknown function (DUF3035)
TPR_11 (PF13414, IPR011990): TPR repeat
G0-G1_switch_2 (PF15103, IPR016821): G0/G1 switch protein 2
CCDC66 (PF15236): Coiled-coil domain-containing protein 66
6 EWSR1oncoprotein40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
7 FBXW7suppressor200Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
8 FNTBinteractor100Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
9 GPS2oncoprotein100G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
10 GSTA1interactor200GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
11 HARSinteractor100HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
12 HAUS7interactor21.0000M3 (PF09213, IPR015296): M3
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
13 HMGCS1interactor100HMG_CoA_synt_C (PF08540, IPR013746): Hydroxymethylglutaryl-coenzyme A synthase C terminal
HMG_CoA_synt_N (PF01154, IPR013528): Hydroxymethylglutaryl-coenzyme A synthase N terminal
14 ITSN1interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
15 NEK9interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
16 NFKBIAoncoprotein100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
17 PPP1R18interactor100Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
18 PSMD14interactor100JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
19 RPS5interactor100Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
20 RTP5interactor100zf-3CxxC (PF13695, IPR027377): Zinc-binding domain
21 SEC13interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
22 SF3B3interactor100CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
23 SIRT1suppressor31.0000DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
24 TRAF4oncoprotein31.0000MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
25 UBXN1interactor200Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
26 USP15oncoprotein31.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
27 YLPM1interactor100DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Com_YlbF (PF06133, IPR010368): Control of competence regulator ComK, YlbF/YmcA
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
AAA_33 (PF13671): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 SPDL1parental proteinPox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF2911 (PF11138, IPR021314): Protein of unknown function (DUF2911)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II

B a c k    t o    T o p ⇑