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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BQ649564 is the fusion of parental proteins ALDH7A1, MRPS15 (from a repository: Wed Jan 25 06:51:34 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins9 (30.00 %)
The number (and %) of the tumor suppressors2 (6.67 %)
Total number of binary PPIs (saturation %)120 (27.59 %)
The number (and %) of affected PPIs29 (24.17 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI7.267
Assortativity coefficient-0.2242
The network average Clustering coefficient0.585
The number (and %) of a zero Clustering coefficients4 (13.33 %)
The number (and %) of a zero Betweenness Centrality7 (23.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MRPS15,ALDH7A1 All fusions
: BQ649564;
Proteins found in more fusions EPS8 (see 1 fusions); APP (see 4 fusions); YWHAH (see 2 fusions); G6PD (see 3 fusions); YWHAG (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BQ649564chimera290.197496.152Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
2 ABATinteractor21.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
3 APPprotein found in more fusions80.38110.019APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ASNSoncoprotein90.7224.533Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
5 CAPN2interactor51.0000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
6 CAPNS1interactor120.59113.419EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7 CATsuppressor60.7002.067Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
8 EIF5interactor100.60010.167CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
9 EPS8oncoprotein200DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
10 ERP44interactor40.6670.800Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
11 FERMT2interactor80.6795.333FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
12 G6PDprotein found in more fusions100.6119.119G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
13 HMGB3interactor31.0000HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
14 KBTBD7interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
15 KIF2Ainteractor200Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
AAA_23 (PF13476): AAA domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
16 LDHBinteractor100.47215.667Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
17 PDIA4interactor90.6397.967Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
18 PGDoncoprotein60.8002.0006PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
19 PPIAinteractor30.6670.400Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
20 PPP1CAsuppressor70.7621.967Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
21 PRDX5interactor40.8330.400Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
22 SCPEP1interactor60.8670.667Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
23 SORDinteractor60.6003.667ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
24 STK24interactor80.7142.367DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
25 TBCBinteractor120.59114.900CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
26 UBA5interactor200Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
27 YWHAEoncoprotein130.55119.78614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
28 YWHAGprotein found in more fusions100.6117.90014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
29 YWHAHprotein found in more fusions130.56117.41914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
30 YWHAQinteractor90.7225.28614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACSL4interactorAMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
2 ALDH7A1parental proteinAldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3 CAND1interactorAdaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
4 CDC73suppressorCDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
5 COPS5interactorJAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
6 COQ2interactorUbiA (PF01040, IPR000537): UbiA prenyltransferase family
7 COQ4interactorCoq4 (PF05019, IPR007715): Coenzyme Q (ubiquinone) biosynthesis protein Coq4
8 CPT2interactorCarn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
9 CUL3interactorCullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10 DDA1interactorDDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
11 ESR2suppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
12 FAHD2AinteractorFAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
13 GLAinteractorMelibiase_2 (PF16499, IPR002241): Alpha galactosidase A
14 GOT1interactorAminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
15 GRSF1interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
VWA_N2 (PF16164, IPR032361): VWA N-terminal
16 HIBCHinteractorECH_2 (PF16113, IPR032259): Enoyl-CoA hydratase/isomerase
17 HNRNPA1interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
18 HNRNPUinteractorCDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
19 L3HYPDHinteractorPro_racemase (PF05544, IPR008794): Proline racemase
20 MPP1oncoproteinPDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
21 MRPL58interactorRF-1 (PF00472, IPR000352): RF-1 domain
22 MRPS15parental proteinRibosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
23 MRPS31interactorMRP-S31 (PF15433, IPR026299): Mitochondrial 28S ribosomal protein S31
24 MRPS5interactorRibosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
25 ORC1interactorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
BAH (PF01426, IPR001025, SM00439): BAH domain
Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
26 PARK2suppressorIBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
27 PHF8interactorJmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
PHD (PF00628, IPR019787, SM00249): PHD-finger
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
28 POU5F1oncoproteinPou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
29 PTCD3interactorPPR (PF01535, IPR002885): PPR repeat
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
30 TRA2AinteractorDUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
31 TRMT10BinteractortRNA_m1G_MT (PF01746, IPR016009): tRNA (Guanine-1)-methyltransferase
32 VPS16interactorVps16_C (PF04840, IPR006925): Vps16, C-terminal region
Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
33 XRCC4interactorXRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4

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