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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BQ423643 is the fusion of parental proteins CD3EAP (from a repository: Fri Feb 9 09:56:51 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins2 (18.18 %)
The number (and %) of the tumor suppressors1 (9.09 %)
Total number of binary PPIs (saturation %)26 (47.27 %)
The number (and %) of affected PPIs10 (38.46 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI4.000
Assortativity coefficient-0.1124
The network average Clustering coefficient0.739
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality5 (45.45 %)


List of the fusions

PPI for parental proteins: CD3EAP,ERCC1 All fusions
: BQ423643;
Proteins found in more fusions NCL (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BQ423643chimera100.26748.333RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
2 ARRB1interactor30.6670.667Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
3 CD3Einteractor21.0000ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif
P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter
Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
4 NBNsuppressor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
5 NCLprotein found in more fusions60.4005.667DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
6 POLR1Ainteractor60.4677.667RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
7 POLR1Binteractor31.0000RNA_pol_Rpa2_4 (PF06883, IPR009674): RNA polymerase I, Rpa2 specific domain
RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit
RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3
RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6
RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
8 RNF2interactor50.6671.667zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
9 SKAP1interactor41.0000PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
10 TBPinteractor31.0000TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
11 UBTFinteractor40.6672.000Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HMG_box_2 (PF09011, IPR009071): HMG-box domain
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF4473 (PF14747, IPR027913): Domain of unknown function (DUF4473)
HMG_box_5 (PF14887, IPR029215): HMG (high mobility group) box 5

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CD3EAPparental proteinPol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
2 GPN3interactorATP_bind_1 (PF03029, IPR004130): Conserved hypothetical ATP binding protein
3 GTF3C1interactorB-block_TFIIIC (PF04182, IPR007309): B-block binding subunit of TFIIIC
4 POLR1CinteractorRNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
5 POLR1DinteractorRNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
6 POLR1EinteractorRNA_pol_I_A49 (PF06870, IPR009668): A49-like RNA polymerase I associated factor
7 POLR2FinteractorRNA_pol_Rpb6 (PF01192, IPR006110): RNA polymerase Rpb6
8 SCARNA22interactorNA
9 TAF1CinteractorLRV (PF01816, IPR004830): Leucine rich repeat variant

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