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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BQ375227 is the fusion of parental proteins HS6ST1, PEBP1 (from a repository: Mon Feb 27 08:28:45 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins12 (31.58 %)
The number (and %) of the tumor suppressors3 (7.89 %)
Total number of binary PPIs (saturation %)104 (14.79 %)
The number (and %) of affected PPIs37 (35.58 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.737
Assortativity coefficient-0.2787
The network average Clustering coefficient0.542
The number (and %) of a zero Clustering coefficients7 (18.42 %)
The number (and %) of a zero Betweenness Centrality15 (39.47 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PEBP1,HS6ST1 All fusions
: BQ375227;
Proteins found in more fusions LGALS3 (see 2 fusions); TRAF6 (see 1 fusions); MAPK1 (see 1 fusions); SOD2 (see 3 fusions); PRDX1 (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BQ375227chimera370.0801081.300PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
2 ABCE1interactor50.5002.667ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 AKT1oncoprotein50.5003.000PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 ALOX15suppressor100Lipoxygenase (PF00305, IPR013819): Lipoxygenase
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
5 ASNSoncoprotein30.6670.667Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
6 BAG3oncoprotein50.5003.000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
7 C11orf54interactor40.6671.667DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
8 CFL1interactor80.5369.067Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
9 GNPDA2interactor31.0000Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
10 GRK2interactor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
11 HNF1Aoncoprotein200HNF-1_N (PF04814, IPR006899): Hepatocyte nuclear factor 1 (HNF-1), N terminus
HNF-1A_C (PF04813, IPR006898): Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
HNF-1B_C (PF04812, IPR006897): Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
12 HSPE1interactor80.46410.900Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
13 IQCB1interactor30.6670.500DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
14 LDHAL6Ainteractor40.6671.333Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
15 LGALS3oncoprotein41.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
16 MAP2K1oncoprotein41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3216 (PF11505, IPR023108): Protein of unknown function (DUF3216)
17 MAPK1oncoprotein50.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
18 MOV10interactor30.6671.000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
19 NKX3-1suppressor100Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
20 NXF1interactor40.6671.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
21 PABPC3interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
22 PGLSinteractor100Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
23 PPIAinteractor50.7003.000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
24 PRDX1oncoprotein70.6673.733AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
25 PRDX5interactor70.6195.400Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
26 PTGR1interactor31.0000ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_N_2 (PF16884): N-terminal domain of oxidoreductase
27 RAF1oncoprotein70.4009.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
28 RFKinteractor21.0000Flavokinase (PF01687, IPR015865, SM00904): Riboflavin kinase
29 SCLT1oncoprotein100DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
30 SLC25A32interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
31 SOD1interactor160.27666.967Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
32 SOD2suppressor60.6002.733Sod_Fe_C (PF02777, IPR019832): Iron/manganese superoxide dismutases, C-terminal domain
Sod_Fe_N (PF00081, IPR019831): Iron/manganese superoxide dismutases, alpha-hairpin domain
33 SPRinteractor70.5247.567adh_short (PF00106, IPR002198): short chain dehydrogenase
34 STC2interactor100Stanniocalcin (PF03298, IPR004978): Stanniocalcin family
35 STIP1interactor40.6671.333TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
36 TRAF6protein found in more fusions31.0000SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
37 UCHL3interactor50.5002.500Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
38 YKT6interactor50.4005.667Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 B3GNT3interactorGalactosyl_T (PF01762, IPR002659): Galactosyltransferase
2 CHRNA9interactorNeur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
3 GSDMBinteractorGasdermin (PF04598, IPR007677): Gasdermin family
4 HS6ST1parental proteinSulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
5 IGBP1interactorTAP42 (PF04177, IPR007304): TAP42-like family
6 ITM2BinteractorBRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SpoVG (PF04026, IPR007170): SpoVG
7 NRG1interactorEGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
8 PEBP1parental proteinPBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein

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