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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)102
The number (and %) of the onco-proteins23 (22.55 %)
The number (and %) of the tumor suppressors16 (15.69 %)
Total number of binary PPIs (saturation %)936 (18.17 %)
The number (and %) of affected PPIs101 (10.79 %)
The number of possible different fusions21
PPI diameter2
PPI radius1
The average degree of PPI17.451
Assortativity coefficient-0.1666
The network average Clustering coefficient0.553
The number (and %) of a zero Clustering coefficients4 (3.92 %)
The number (and %) of a zero Betweenness Centrality7 (6.86 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: POLR2E All fusions
: BQ362075;
Proteins found in more fusions POLR2F/PIH1D1 (see 1 fusions); URI1 (see 3 fusions); LZTR1 (see 2 fusions); HSP90AA1 (see 2 fusions); EEF1A1 (see 1 fusions); TRIM28 (see 1 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); OFD1 (see 1 fusions); MYC (see 1 fusions); CDH1 (see 3 fusions); FOS (see 4 fusions); POLR2A (see 2 fusions); COPS5 (see 1 fusions); PML (see 4 fusions); RPA1 (see 1 fusions); USP11 (see 4 fusions); NEDD4 (see 1 fusions); TRIM29 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BQ362075chimera1010.1564408.151RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain
RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain
2 ARRB1interactor110.49110.024Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
3 ARRB2interactor160.35832.247Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
4 BARD1suppressor130.5769.951BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
5 BRCA1suppressor260.44363.723BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6 CCDC8interactor170.48324.506Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
7 CDH1suppressor70.4672.669Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
8 COPS5protein found in more fusions150.44018.318JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
9 CUL3protein found in more fusions290.294134.694Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10 CUL7protein found in more fusions180.49320.170ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
11 EEF1A1suppressor230.39454.074GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
12 ESR1suppressor350.374172.023Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
13 FKBP14interactor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
14 FOSoncoprotein50.5001.682bZIP_1 (PF00170, IPR004827): bZIP transcription factor
15 GTF2Binteractor100.8671.509Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
16 GTF2F2interactor150.59022.965TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
17 HSP90AA1oncoprotein200.33952.131HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
18 HSP90B1suppressor90.3897.828CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
19 HTATSF1interactor60.6672.109BUD22 (PF09073, IPR015158): BUD22
Conotoxin (PF02950, IPR004214): Conotoxin
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
20 IKBKGinteractor150.35228.225CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
21 INTS3interactor130.7058.056SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
Fn_bind (PF02986, IPR004237): Fibronectin binding repeat
Ints3 (PF10189, IPR019333): Integrator complex subunit 3
22 INTS5interactor110.9640.309INTS5_N (PF14837, IPR029445): Integrator complex subunit 5 N-terminus
INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus
23 INTS6suppressor140.6929.766VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
INT_SG_DDX_CT_C (PF15300, IPR029307): INTS6/SAGE1/DDX26B/CT45 C-terminus
DUF4596 (PF15363, IPR027907): Domain of unknown function (DUF4596)
24 ITCHinteractor110.5567.202C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
25 LAMB1interactor100Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
YscO (PF07321, IPR009929): Type III secretion protein YscO
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
Ntox1 (PF15500, IPR029137): Putative RNase-like toxin, toxin_1
26 LZTR1oncoprotein70.6002.026BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
27 MDC1suppressor150.46717.698FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
28 MED1interactor140.7824.821Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
29 MED10interactor200.8007.053Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
30 MED12oncoprotein110.6555.100Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877)
Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain
Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
31 MED19interactor200.8016.516Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
32 MED26interactor220.67526.051Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
33 MED28interactor180.73516.928cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
Med28 (PF11594, IPR021640): Mediator complex subunit 28
34 MED29interactor200.7848.045Med29 (PF11568, IPR021018): Mediator complex subunit 29
35 MED9interactor160.8583.048Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
36 MYConcoprotein170.45030.037HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
37 NEDD4suppressor130.47012.402Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
38 NPHP1interactor70.7332.650SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FAM176 (PF14851): FAM176 family
Speriolin_N (PF15058, IPR029385): Speriolin N terminus
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
39 NPM1suppressor210.40050.705Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
40 OBSL1interactor180.49318.453BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
41 OFD1protein found in more fusions90.6434.209APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
42 PAAF1interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
43 PIH1D1protein found in more fusions280.370116.514PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
44 PMLsuppressor50.5001.619zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
45 POLR1Ainteractor250.36390.211RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
46 POLR1Binteractor180.43144.848RNA_pol_Rpa2_4 (PF06883, IPR009674): RNA polymerase I, Rpa2 specific domain
RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit
RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3
RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6
RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
47 POLR1Cinteractor230.45168.087RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
48 POLR1Dinteractor140.7695.337RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
49 POLR2Aprotein found in more fusions550.304445.726RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
50 POLR2Binteractor510.293427.487RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit
RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3
RNA_pol_Rpb2_4 (PF04566, IPR007646): RNA polymerase Rpb2, domain 4
RNA_pol_Rpb2_5 (PF04567, IPR007647): RNA polymerase Rpb2, domain 5
RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6
RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
51 POLR2Cinteractor440.375197.536RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
52 POLR2Dinteractor320.47699.975RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
Tfb4 (PF03850, IPR004600): Transcription factor Tfb4
53 POLR2Fprotein found in more fusions390.393196.415RNA_pol_Rpb6 (PF01192, IPR006110): RNA polymerase Rpb6
54 POLR2Ginteractor380.468100.297SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
55 POLR2Hinteractor410.397192.666RNA_pol_Rpb8 (PF03870, IPR005570, SM00658): RNA polymerase Rpb8
56 POLR2Iinteractor280.55845.578RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
CpXC (PF14353, IPR025682): CpXC protein
57 POLR2Jinteractor310.50357.961RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
58 POLR2Kinteractor210.67416.011DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
59 POLR2Linteractor290.47367.157RNA_pol_N (PF01194, IPR000268): RNA polymerases N / 8 kDa subunit
60 POLR2Minteractor160.7426.985GCOM2 (PF15328, IPR026213): Putative GRINL1B complex locus protein 2
61 POLR3Ainteractor230.47859.852RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
62 POLR3Binteractor180.62120.676RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit
RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3
RNA_pol_Rpb2_4 (PF04566, IPR007646): RNA polymerase Rpb2, domain 4
RNA_pol_Rpb2_5 (PF04567, IPR007647): RNA polymerase Rpb2, domain 5
RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6
RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
63 POLR3Cinteractor140.8134.118HTH_9 (PF08221, IPR013197): RNA polymerase III subunit RPC82 helix-turn-helix domain
NIT (PF08376, IPR013587): Nitrate and nitrite sensing
RNA_pol_Rpc82 (PF05645, IPR008806): RNA polymerase III subunit RPC82
HD_4 (PF13328, IPR003607): HD domain
64 POLR3Dinteractor150.71410.124Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
65 POLR3Einteractor170.58822.621Sin_N (PF04801, IPR006886): Sin-like protein conserved region
DUF2382 (PF09557, IPR019060): Domain of unknown function (DUF2382)
66 POLR3Finteractor120.8333.005RNA_pol_Rpc34 (PF05158, IPR007832): RNA polymerase Rpc34 subunit
67 POLR3Hinteractor110.9640.382RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25
SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
68 POLR3Kinteractor100.9330.675RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
zf-ribbon_3 (PF13248): zinc-ribbon domain
zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
69 PPP1CAsuppressor230.39968.572Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
70 PPP1R3Ainteractor70.9050.487CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21)
71 PSMB9interactor160.9240.894Proteasome (PF00227, IPR001353): Proteasome subunit
72 RABEP2interactor21.0000Rab5-bind (PF09311, IPR015390): Rabaptin-like protein
Rabaptin (PF03528, IPR018514): Rabaptin
73 RECQL5oncoprotein120.8642.210DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
RecQ5 (PF06959, IPR010716): RecQ helicase protein-like 5 (RecQ5)
SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
TAtT (PF16811, IPR031823): TRAP transporter T-component
74 RNF2interactor170.34240.267zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
75 RPA1suppressor220.44341.016Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
76 RPA2oncoprotein160.47518.632RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
77 RPA3interactor170.47518.632Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
78 RPAP3interactor250.38080.046TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
79 RPRD1Binteractor180.60822.913CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
Efg1 (PF10153, IPR019310): rRNA-processing protein Efg1
CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
80 RPS5interactor130.55111.768Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
81 RUVBL1oncoprotein250.35185.035TIP49 (PF06068, IPR010339): TIP49 C-terminus
82 RUVBL2oncoprotein310.359131.824TIP49 (PF06068, IPR010339): TIP49 C-terminus
83 SEC13interactor50.6670.376WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
84 SMG1interactor70.5332.633Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
SMG1 (PF15785, IPR031559): Serine/threonine-protein kinase smg-1
85 SRConcoprotein230.48956.688Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
86 SRPK1interactor80.5365.094FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
87 SUPT5Hinteractor230.42761.940KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
88 SYT5interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
MLANA (PF14991, IPR029242): Protein melan-A
89 TAF10interactor40.8330.200TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
90 TAF15oncoprotein140.38522.574API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
GRP (PF07172, IPR010800): Glycine rich protein family
Presenilin (PF01080, IPR001108): Presenilin
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
91 TCEB3suppressor160.8084.664Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
92 TRIM28protein found in more fusions170.44223.219ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
93 TRIM29protein found in more fusions70.6001.604MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
94 TTI1interactor70.8571.200Dopey_N (PF04118, IPR007249): Dopey, N-terminal
HEAT (PF02985, IPR000357): HEAT repeat
VHS (PF00790, IPR002014, SM00288): VHS domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
95 URI1protein found in more fusions180.47828.279CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
Prefoldin (PF02996, IPR004127): Prefoldin subunit
DUF3835 (PF12927, IPR024325): Domain of unknown function (DUF3835)
SCAPER_N (PF16501, IPR032446): S phase cyclin A-associated protein in the endoplasmic reticulum
96 USP11protein found in more fusions60.8000.733Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
97 UXTinteractor90.8332.219Prefoldin (PF02996, IPR004127): Prefoldin subunit
98 WWOXsuppressor110.52711.014adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
99 XPO1interactor280.320122.996CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
100 XRCC5suppressor200.35144.335Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
101 ZNRD1interactor41.0000RecR (PF02132, IPR023628): RecR protein
RNA_POL_M_15KD (PF02150, IPR001529): RNA polymerases M/15 Kd subunit
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
102 ZSCAN1interactor41.0000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Tautomerase_2 (PF14552, IPR004370): Tautomerase enzyme

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 INTS10interactorNA
2 POLR2Eparental proteinRNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain
RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain

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