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Fusion ID: Protein names:	BQ300560
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Visualization interactions

Cytoscape Web for: BQ300560 is the fusion of parental proteins PTPRF (from a repository: Fri May 26 08:34:50 2017)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	39
The number (and %) of the onco-proteins	14 (35.90 %)
The number (and %) of the tumor suppressors	4 (10.26 %)
Total number of binary PPIs (saturation %)	114 (15.38 %)
The number (and %) of affected PPIs	38 (33.33 %)
The number of possible different fusions	8
PPI diameter	2
PPI radius	1
The average degree of PPI	5.026
Assortativity coefficient	-0.2755
The network average Clustering coefficient	0.536
The number (and %) of a zero Clustering coefficients	8 (20.51 %)
The number (and %) of a zero Betweenness Centrality	16 (41.03 %)

ACTIVE INTERACTORS

MISSING INTERACTORS

List of the fusions
PPI for parental proteins: PTPRF	All fusions : BQ300560;
Proteins found in more fusions	PRPF40A (see 2 fusions); CUL7 (see 2 fusions); PFKM (see 1 fusions); MAPK1 (see 1 fusions); EGFR (see 2 fusions); NID1 (see 1 fusions); PPFIA1 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	BQ300560	chimera	38	0.085	1094.467	Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST) C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
2	ABCE1	interactor	5	0.833	0.500	ABC_tran (PF00005, IPR003439): ABC transporter Fer4 (PF00037, IPR001450): 4Fe-4S binding domain RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain AAA_29 (PF13555): P-loop containing region of AAA domain
3	ARPC3	interactor	2	1.000	0	P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
4	CAV1	suppressor	7	0.476	8.233	Caveolin (PF01146, IPR001612): Caveolin
5	CDKN2AIP	interactor	1	0	0	XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
6	CEACAM21	interactor	2	1.000	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain
7	CTNNB1	oncoprotein	8	0.429	14.167	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
8	CUL7	protein found in more fusions	6	0.400	4.833	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
9	DNAAF5	interactor	7	0.476	7.233	HEAT (PF02985, IPR000357): HEAT repeat Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
10	EGFR	oncoprotein	10	0.500	10.400	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
11	GIT1	interactor	7	0.600	4.733	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) FlxA (PF14282, IPR025577): FlxA-like protein GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
12	GRK2	interactor	5	0.400	3.733	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
13	HACL1	interactor	2	0	0	TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
14	HEPACAM2	interactor	1	0	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain PgaD (PF13994, IPR023829): PgaD-like protein
15	JUP	suppressor	6	0.600	4.500	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
16	MAPK1	oncoprotein	10	0.361	17.067	Pkinase (PF00069, IPR000719): Protein kinase domain
17	NAA50	interactor	1	0	0	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
18	NID1	protein found in more fusions	3	1.000	0	EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain G2F (PF07474, IPR006605, SM00682): G2F domain NIDO (PF06119, IPR003886, SM00539): Nidogen-like Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EGF_3 (PF12947, IPR024731): EGF domain FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
19	NPLOC4	interactor	5	0.600	3.167	NPL4 (PF05021, IPR007717): NPL4 family zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
20	NTRK1	oncoprotein	19	0.248	97.900	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
21	PFKM	protein found in more fusions	6	0.800	1.000	PFK (PF00365, IPR000023): Phosphofructokinase
22	PICALM	oncoprotein	6	0.600	4.500	ANTH (PF07651, IPR011417): ANTH domain
23	PPFIA1	protein found in more fusions	7	0.667	4.000	HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 Cluap1 (PF10234, IPR019366): Clusterin-associated protein-1 TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus FAM76 (PF16046, IPR032017): FAM76 protein CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
24	PPFIA2	interactor	5	1.000	0	DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745) HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7) HWE_HK (PF07536, IPR011102, SM00911): HWE histidine kinase IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SlyX (PF04102, IPR007236): SlyX TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
25	PPFIA3	interactor	5	1.000	0	DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745) T2SSF (PF00482, IPR018076): Type II secretion system (T2SS), protein F SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) Tup_N (PF08581, IPR013890): Tup N-terminal FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 FAM76 (PF16046, IPR032017): FAM76 protein
26	PPP2R5D	interactor	4	0.833	0.667	B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
27	PPWD1	interactor	3	0.667	0.400	DUF505 (PF04458, IPR007548): Protein of unknown function (DUF505) Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
28	PRPF40A	protein found in more fusions	4	0.667	0.500	FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
29	RET	oncoprotein	5	0.833	0.333	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
30	RYK	oncoprotein	4	0.500	2.500	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase WIF (PF02019, IPR003306, SM00469): WIF domain
31	SCN2B	interactor	1	0	0	DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191) V-set (PF07686, IPR013106): Immunoglobulin V-set domain
32	SEPHS1	interactor	2	0	0	AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
33	SKIL	suppressor	3	1.000	0	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
34	TGFBR2	suppressor	2	1.000	0	ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
35	TRIO	oncoprotein	2	1.000	0	T3SS_needle_E (PF08988, IPR012671): Type III secretion system, cytoplasmic E component of needle GRP (PF07172, IPR010800): Glycine rich protein family I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pap_E4 (PF02711, IPR003861): E4 protein PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain Spectrin (PF00435, IPR002017): Spectrin repeat CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain PH_10 (PF15411): Pleckstrin homology domain SH3-RhoG_link (PF16609): SH3-RhoGEF linking unstructured region
36	TSTA3	interactor	1	0	0	Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family NICE-3 (PF07406, IPR010876): NICE-3 protein Polysacc_synt_2 (PF02719, IPR003869): Polysaccharide biosynthesis protein
37	UFD1L	interactor	3	0.667	0.667	UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
38	UNK	interactor	3	0.667	0.500	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
39	ZNF512B	interactor	1	0	0	YTV (PF07639, IPR011521): YTV zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

B a c k t o T o p ⇑

List of missing interactors