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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BQ224571 is the fusion of parental proteins FANCG (from a repository: Sat Nov 12 16:46:27 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)10
The number (and %) of the onco-proteins4 (40.00 %)
The number (and %) of the tumor suppressors2 (20.00 %)
Total number of binary PPIs (saturation %)18 (40.00 %)
The number (and %) of affected PPIs9 (50.00 %)
The number of possible different fusions1
PPI diameter2
PPI radius1
The average degree of PPI2.800
Assortativity coefficient-0.0353
The network average Clustering coefficient0.631
The number (and %) of a zero Clustering coefficients2 (20.00 %)
The number (and %) of a zero Betweenness Centrality7 (70.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: FANCG All fusions
: BQ224571;
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BQ224571chimera90.13958.000Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
2 BLMsuppressor40.6671.000BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein
BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
3 BRCC3interactor31.0000JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
4 CDK1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
5 CTNNB1oncoprotein21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
6 PSMB1interactor100Proteasome (PF00227, IPR001353): Proteasome subunit
7 TOP3Aoncoprotein21.0000A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
Topoisom_bac (PF01131, IPR013497): DNA topoisomerase
Toprim (PF01751, IPR006171, SM00493): Toprim domain
zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-GRF (PF06839, IPR010666): GRF zinc finger
zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
8 UIMC1suppressor40.5003.000Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
9 USHBP1interactor200DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
10 XPO1interactor21.0000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BRCA2suppressorBRCA-2_helical (PF09169, IPR015252): BRCA2, helical
BRCA-2_OB1 (PF09103, IPR015187): BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
BRCA2 (PF00634, IPR002093): BRCA2 repeat
Tower (PF09121, IPR015205): Tower
2 CAPN1interactorCalpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
3 CENPSsuppressorCENP-S (PF15630, IPR029003): CENP-S protein
COMMD1_N (PF17221): COMMD1 N-terminal domain
4 CENPXinteractorCENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X
5 CYP2E1interactorp450 (PF00067, IPR001128): Cytochrome P450
6 DOK5interactorIRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
7 ERCC1oncoproteinRad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
HHH_5 (PF14520): Helix-hairpin-helix domain
8 ERCC4oncoproteinERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
LUC7 (PF03194, IPR004882): LUC7 N_terminus
T2SSM_b (PF10741, IPR007690): Type II secretion system (T2SS), protein M subtype b
HHH_5 (PF14520): Helix-hairpin-helix domain
9 FAAP100interactorFANCAA (PF15146, IPR029251): Fanconi anemia-associated
10 FAAP20interactorUBZ_FAAP20 (PF15750, IPR031490): Ubiquitin-binding zinc-finger
FANCA_interact (PF15751, IPR031491): FAAP20 FANCA interaction domain
11 FAAP24interactorRad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
HHH_2 (PF12826): Helix-hairpin-helix motif
12 FAM175AinteractorDUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
13 FAN1interactorVRR_NUC (PF08774, IPR014883, SM00990): VRR-NUC domain
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TPR_12 (PF13424): Tetratricopeptide repeat
DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
14 FANCAoncoproteinFanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein
Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
15 FANCBinteractorDP (PF08781, IPR014889, SM01138): Transcription factor DP
16 FANCConcoproteinFanconi_C (PF02106, IPR000686): Fanconi anaemia group C protein
17 FANCD2oncoproteinFancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
18 FANCEoncoproteinFA_FANCE (PF11510, IPR021025): Fanconi Anaemia group E protein FANCE
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
19 FANCFoncoproteinFANCF (PF11107): Fanconi anemia group F protein (FANCF)
20 FANCGparental proteinBTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
21 FANCLinteractorWD-3 (PF09765, IPR019162): WD-repeat region
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
22 FANCMinteractorERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MRC1 (PF09444, IPR018564): MRC1-like domain
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
HHH_2 (PF12826): Helix-hairpin-helix motif
FANCM-MHF_bd (PF16783, IPR031879): FANCM to MHF binding domain
23 FTSJ3interactorDUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein
Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
24 GABPB1oncoproteinAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
Ank_4 (PF13637): Ankyrin repeats (many copies)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
25 HES1oncoproteinHairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
26 KIF15interactorBcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
STE (PF02200, IPR003120, SM00424): STE like transcription factor
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
FlxA (PF14282, IPR025577): FlxA-like protein
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
27 KRT19suppressorFilament (PF00038, IPR001664): Intermediate filament protein
28 NLGN3interactorCOesterase (PF00135, IPR002018): Carboxylesterase family
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
29 POLNinteractorDNA_pol_A (PF00476, IPR001098, SM00482): DNA polymerase family A
30 PRDX3interactorAhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
31 RPA1suppressorRep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
32 RTN2interactorReticulon (PF02453, IPR003388): Reticulon
33 SAMD3interactorSAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
RecG_wedge (PF17191): RecG wedge domain
34 SPTAN1oncoproteinEFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
35 VPS50interactorVps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
36 XRCC3oncoproteinRad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
37 ZBED1interactorDimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF4413 (PF14372, IPR025525): Domain of unknown function (DUF4413)

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