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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)117
The number (and %) of the onco-proteins31 (26.50 %)
The number (and %) of the tumor suppressors8 (6.84 %)
Total number of binary PPIs (saturation %)377 (5.56 %)
The number (and %) of affected PPIs116 (30.77 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI5.880
Assortativity coefficient-0.4014
The network average Clustering coefficient0.550
The number (and %) of a zero Clustering coefficients24 (20.51 %)
The number (and %) of a zero Betweenness Centrality58 (49.57 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: KIF11 All fusions
: BQ212450;
Proteins found in more fusions ORC2 (see 2 fusions); KAT2B (see 1 fusions); TRAF4 (see 1 fusions); KMT2A (see 16 fusions); GAN (see 1 fusions); YWHAZ (see 1 fusions); PLEKHA5 (see 1 fusions); NPM1 (see 1 fusions); PFKM (see 1 fusions); WHSC1 (see 1 fusions); PEX14 (see 1 fusions); SRPK2 (see 1 fusions); SUV39H1 (see 1 fusions); PINK1 (see 3 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BQ212450chimera1160.03411442.760Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
2 ACSL3oncoprotein21.0000AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
3 ACSL5oncoprotein100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
4 ACTR10interactor21.0000Actin (PF00022, IPR004000, SM00268): Actin
5 ADARB2oncoprotein100dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
A_deamin (PF02137, IPR002466, SM00552): Adenosine-deaminase (editase) domain
6 ANK3interactor21.0000BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Death (PF00531, IPR000488, SM00005): Death domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
DUF3008 (PF11450, IPR021553): Protein of unknwon function (DUF3008)
DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
7 ANKLE2interactor21.0000Cauli_VI (PF01693, IPR011320): Caulimovirus viroplasmin
LEM (PF03020, IPR003887, SM00540): LEM domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
8 ANKS6interactor100DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
9 ANXA1suppressor31.0000Annexin (PF00191, IPR018502, SM00335): Annexin
10 ANXA7suppressor21.0000Annexin (PF00191, IPR018502, SM00335): Annexin
11 AP2A2interactor30.6670.200Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
12 AP3M1interactor31.0000Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
13 ARID4Binteractor30.6671.000ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
CDC45 (PF02724, IPR003874): CDC45-like protein
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
E7 (PF00527, IPR000148): E7 protein, Early protein
NOA36 (PF06524, IPR010531): NOA36 protein
PWWP (PF00855, IPR000313, SM00293): PWWP domain
RBB1NT (PF08169, IPR012603): RBB1NT (NUC162) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
14 BORCS6interactor40.5003.000DUF2365 (PF10157, IPR019314): Uncharacterized conserved protein (DUF2365)
15 BRPF1interactor21.0000Pap_E4 (PF02711, IPR003861): E4 protein
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
PWWP (PF00855, IPR000313, SM00293): PWWP domain
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
16 C2orf69interactor21.0000UPF0565 (PF10561, IPR018881): Uncharacterised protein family UPF0565
17 CALD1interactor40.6671.200Caldesmon (PF02029, IPR006018): Caldesmon
DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
18 CARNMT1interactor21.0000N2227 (PF07942, IPR012901): N2227-like protein
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
19 CASP1oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
20 CDC5Linteractor160.33345.733OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
21 CDK1oncoprotein60.6002.367Pkinase (PF00069, IPR000719): Protein kinase domain
22 CEP295interactor100CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain
SseC (PF04888, IPR006972): Secretion system effector C (SseC) like family
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
CFIA_Pcf11 (PF11526, IPR021605): Subunit of cleavage factor IA Pcf11
ALMS_motif (PF15309, IPR029299): ALMS motif
23 CEP350interactor40.5002.167CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
Complex1_LYR_2 (PF13233): Complex1_LYR-like
AAA_23 (PF13476): AAA domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
24 CETN2interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
25 DCTN1interactor120.21840.186Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
26 DDX51interactor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3330 (PF11809, IPR021767): Domain of unknown function (DUF3330)
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
27 DECR1interactor31.0000adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
28 DGCR8interactor21.0000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
WW (PF00397, IPR001202, SM00456): WW domain
29 DHRS13interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
30 DNM3interactor100Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
31 DPPA4interactor200Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
DCR (PF14047, IPR025891): Dppa2/4 conserved region
Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
32 DUSP11interactor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
33 DYNLRB1interactor100Robl_LC7 (PF03259, IPR004942, SM00960): Roadblock/LC7 domain
34 EDC4interactor40.6670.833DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
35 EIF3Aoncoprotein110.47316.205DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003)
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
PCI (PF01399, IPR000717, SM00088): PCI domain
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
36 EIF3Ioncoprotein80.6075.367ISN1 (PF06437, IPR009453): IMP-specific 5'-nucleotidase
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
37 ELAVL1oncoprotein170.19288.267RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
38 FASNinteractor80.5244.286Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain
KR (PF08659, IPR013968, SM00130): KR domain
L27 (PF02828, IPR014775, SM00569): L27 domain
Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
Thioesterase (PF00975, IPR001031): Thioesterase domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
39 FBXO6interactor130.25642.221FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
40 FLYWCH1interactor21.0000FLYWCH (PF04500, IPR007588): FLYWCH zinc finger domain
FLYWCH_N (PF15423, IPR029279): FLYWCH-type zinc finger-containing protein
FLYWCH_u (PF16662): FLYWCH-type zinc finger-containing protein 1
41 GANprotein found in more fusions70.8000.869BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
42 GTPBP4suppressor50.7001.500DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
MRC1 (PF09444, IPR018564): MRC1-like domain
NOG1 (PF06858, IPR010674): Nucleolar GTP-binding protein 1 (NOG1)
NOGCT (PF08155, IPR012973): NOGCT (NUC087) domain
Lip_prot_lig_C (PF10437, IPR019491): Bacterial lipoate protein ligase C-terminus
AAA_16 (PF13191): AAA ATPase domain
43 H2BFSinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
44 H3F3Aoncoprotein40.5002.000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
45 H3F3Concoprotein21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
46 HDLBPoncoprotein50.7003.000BMC (PF00936, IPR000249, SM00877): BMC domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
KH_5 (PF13184, IPR025249): NusA-like KH domain
SLS (PF14611, IPR032741): Mitochondrial inner-membrane-bound regulator
DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
47 HIST1H3Ainteractor110.28929.833Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
48 HSPB8interactor200Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
49 ILVBLinteractor21.0000TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
50 IRAK4interactor100Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
51 KAT2Bprotein found in more fusions70.3339.167Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
52 KIAA0922interactor21.0000TMEM131_like (PF12371, IPR022113): Transmembrane protein 131-like
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
53 KIF5Ainteractor30.6671.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Microtub_bd (PF16796, IPR031852): Microtubule binding
54 KMT2Aoncoprotein50.5002.167AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus
FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SET (PF00856, IPR001214, SM00317): SET domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
55 LAMB1interactor30.6670.200Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
YscO (PF07321, IPR009929): Type III secretion protein YscO
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
Ntox1 (PF15500, IPR029137): Putative RNase-like toxin, toxin_1
56 LDHAinteractor40.6670.200Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
57 LUZP1interactor50.4005.667Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
TMA7 (PF09072, IPR015157): Translation machinery associated TMA7
HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
58 MAP4oncoprotein40.8330.667SdiA-regulated (PF06977, IPR009722): SdiA-regulated
Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
59 MED14interactor50.5003.000Med14 (PF08638, IPR013947): Mediator complex subunit MED14
60 MED4interactor90.22222.567Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
61 MEPCEinteractor60.6003.667Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3)
Methyltransf_23 (PF13489): Methyltransferase domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
62 METTL13interactor31.0000Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
Methyltransf_23 (PF13489): Methyltransferase domain
63 MLF1oncoprotein100Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
64 MLST8interactor100Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
65 MRPL27interactor100Ribosomal_L27 (PF01016, IPR001684): Ribosomal L27 protein
66 MTUS1suppressor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
ZapB (PF06005, IPR009252): Cell division protein ZapB
SRP19 (PF01922, IPR002778): SRP19 protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
67 MYO1Cinteractor60.5335.533IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
68 MYSM1interactor21.0000SWIRM (PF04433, IPR007526): SWIRM domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
69 NCOR1oncoprotein50.5003.500BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
70 NOL7suppressor100NUC129 (PF08157, IPR012579): NUC129 domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
71 NOLC1interactor80.5009.300DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain
Stm1_N (PF09598, IPR019084): Stm1
stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
PAF (PF15715, IPR031444): PCNA-associated factor
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NuDC (PF16273, IPR032572): Nuclear distribution C domain
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
72 NPM1suppressor230.312119.102Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
73 NT5DC3interactor21.00005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
74 NTRK1oncoprotein410.112612.569I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
75 ORC2protein found in more fusions41.0000ORC2 (PF04084, IPR007220): Origin recognition complex subunit 2
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
76 PAN2interactor180.32782.024RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
77 PCID2interactor100PCI (PF01399, IPR000717, SM00088): PCI domain
78 PDE3Ainteractor100PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
79 PEX14protein found in more fusions31.0000HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
80 PFKMprotein found in more fusions60.7001.200PFK (PF00365, IPR000023): Phosphofructokinase
81 PI4K2Ainteractor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
82 PINK1protein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
83 PLEKHA5protein found in more fusions60.4004.500PH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
84 PNMA3interactor100zf-CCHC (PF00098, IPR001878): Zinc knuckle
PNMA (PF14893, IPR026523): PNMA
85 PPARGsuppressor70.3337.667zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
86 PRKCAinteractor80.5716.233C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
87 PRR3interactor21.0000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
88 RAPGEF2interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
89 RBM28interactor31.0000CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
Phage_TAC_13 (PF16459, IPR024410): Phage tail assembly chaperone, TAC
90 RBM45interactor41.0000RNA_bind (PF08675, IPR014789): RNA binding domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
91 RPAP1interactor40.8330.500ATP-synt_B (PF00430, IPR002146): ATP synthase B/B' CF(0)
RPAP1_C (PF08620, IPR013929): RPAP1-like, C-terminal
RPAP1_N (PF08621, IPR013930): RPAP1-like, N-terminal
92 RPL23Ainteractor100.8222.838Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
93 RPL28interactor70.8101.467Ribosomal_L28e (PF01778, IPR029004): Ribosomal L28e protein family
94 RPL32interactor90.8611.967Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
95 RPL36ALinteractor21.0000NOB1_Zn_bind (PF08772, IPR014881): Nin one binding (NOB1) Zn-ribbon like
Ribosomal_L44 (PF00935, IPR000552): Ribosomal protein L44
96 RPL37Ainteractor90.8612.019Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
97 RPS23interactor110.7275.788Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
98 RPS3Ainteractor130.60314.074Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
99 RPS6interactor140.53819.790Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
100 SMURF1interactor100.27817.950C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
101 SNRNP70interactor70.6194.100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
102 SNRPD3interactor80.5008.633LSM (PF01423, IPR001163): LSM domain
103 SNW1protein found in more fusions190.25584.200SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
104 SPATS2interactor21.0000DUF1296 (PF06972, IPR009719): Protein of unknown function (DUF1296)
DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
105 SPIRE2interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
KIND (PF16474, IPR011019, SM00750): Kinase non-catalytic C-lobe domain
106 SRPK2oncoprotein110.28927.567DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
107 SUV39H1protein found in more fusions60.4005.500Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
108 TACC3oncoprotein60.4008.667TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
109 TFDP3interactor100DP (PF08781, IPR014889, SM01138): Transcription factor DP
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
110 TLN1interactor60.5333.686DUF1013 (PF06242, IPR010421): Protein of unknown function (DUF1013)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Talin_middle (PF09141, IPR015224): Talin, middle domain
VBS (PF08913, IPR015009): Vinculin Binding Site
CoatB (PF10389, IPR008020): Bacteriophage coat protein B
LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
FERM_f0 (PF16511, IPR032425): N-terminal or F0 domain of Talin-head FERM
111 TNFAIP3suppressor40.6670.400OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
112 TRAF4oncoprotein31.0000MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
113 TRIP4interactor40.5001.333ASCH (PF04266, IPR007374, SM01022): ASCH domain
UxaC (PF02614, IPR003766): Glucuronate isomerase
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
114 WHSC1oncoprotein31.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
PWWP (PF00855, IPR000313, SM00293): PWWP domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
SET (PF00856, IPR001214, SM00317): SET domain
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
115 YWHAZprotein found in more fusions140.33340.60014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
116 ZGRF1interactor100zf-GRF (PF06839, IPR010666): GRF zinc finger
DUF2439 (PF10382, IPR018838): Protein of unknown function (DUF2439)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
117 ZKSCAN8interactor200KRAB (PF01352, IPR001909, SM00349): KRAB box
SCAN (PF02023, IPR003309, SM00431): SCAN domain
SPX (PF03105, IPR004331): SPX domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 FAM122AinteractorNA
2 KIF11parental proteinBaculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding

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