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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BQ184412 is the fusion of parental proteins EZR, FADS2 (from a repository: Wed Dec 14 12:31:51 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)93
The number (and %) of the onco-proteins28 (30.11 %)
The number (and %) of the tumor suppressors17 (18.28 %)
Total number of binary PPIs (saturation %)432 (10.10 %)
The number (and %) of affected PPIs92 (21.30 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI8.559
Assortativity coefficient-0.2513
The network average Clustering coefficient0.565
The number (and %) of a zero Clustering coefficients9 (9.68 %)
The number (and %) of a zero Betweenness Centrality26 (27.96 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: EZR,FADS2 All fusions
: BQ184412;
Proteins found in more fusions UBE2R2 (see 1 fusions); NF2 (see 1 fusions); CDH1 (see 3 fusions); HLA-B (see 2 fusions); TKT (see 5 fusions); MCM2 (see 1 fusions); PIK3R1 (see 1 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); ACTN1 (see 3 fusions); AHNAK (see 2 fusions); SLC9A3R1 (see 2 fusions); UBA1 (see 2 fusions); TNFRSF1A (see 2 fusions); WWP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BQ184412chimera920.0735948.531ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
2 ACAA2interactor90.7782.370Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3 ACTN1protein found in more fusions90.5368.437CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
4 AHNAKsuppressor70.8670.468DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945)
ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein
DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993)
DUF4097 (PF13349, IPR025164): Putative adhesin
Ntox37 (PF15535, IPR029108): Bacterial toxin 37
5 ARPC3interactor50.8000.536P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
6 ASB6interactor50.6002.833Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
7 AURKAoncoprotein60.5003.833Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
8 BRCA1suppressor90.4649.439BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
9 CASP10interactor91.0000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
10 CASP8suppressor91.0000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
11 CD44suppressor50.5002.436VP4_2 (PF08935, IPR015031): Viral protein VP4 subunit
Xlink (PF00193, IPR000538, SM00445): Extracellular link domain
S36_mt (PF10937, IPR020373): Ribosomal protein S36, mitochondrial
12 CDH1suppressor70.4676.000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
13 CFTRsuppressor90.28614.733ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
14 CLIC4oncoprotein50.5003.354GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
15 CLIC5interactor21.0000GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
16 CROCCinteractor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Rho_Binding (PF08912, IPR015008): Rho Binding
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
SOGA (PF11365, IPR027881): Protein SOGA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
17 CTNNB1oncoprotein150.35246.371Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
18 CUL7protein found in more fusions170.35041.420ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
19 DGKQinteractor100RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
DAGK_acc (PF00609, IPR000756, SM00045): Diacylglycerol kinase accessory domain
DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain
20 DLG1suppressor21.0000L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
21 EIF5A2interactor21.0000EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
22 EIF5AL1interactor31.0000EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
23 ELAVL1oncoprotein180.27969.256RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24 ENO1oncoprotein190.41547.091Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
25 ENO2interactor110.6736.566Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
26 FADDsuppressor81.0000Death (PF00531, IPR000488, SM00005): Death domain
DED (PF01335, IPR001875, SM00031): Death effector domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
27 FASsuppressor110.7338.000Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
28 FHsuppressor90.38916.900Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
29 FKBP9interactor60.6003.833FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
30 GPX4interactor60.9330.182GSHPx (PF00255, IPR000889): Glutathione peroxidase
31 GTF3C4interactor80.42911.278TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
32 GZMMinteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
33 HEXAinteractor50.8001.167Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
34 HEXBinteractor60.4004.000Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
35 HLA-Boncoprotein41.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
36 HSPA4interactor100.51112.237Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
37 HSPH1oncoprotein120.54514.861HSP70 (PF00012, IPR013126): Hsp70 protein
SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
38 ICAM1oncoprotein30.6670.667Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
39 ICAM2interactor30.6670.105ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
SecE (PF00584, IPR001901): SecE/Sec61-gamma subunits of protein translocation complex
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
40 ICAM3interactor21.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
41 IPO5interactor70.3818.100HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
42 IQGAP1interactor130.43624.945CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
43 L1CAMoncoprotein21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
Bravo_FIGEY (PF13882, IPR026966): Bravo-like intracellular region
Ig_3 (PF13927): Immunoglobulin domain
44 LCP1oncoprotein40.6670.327CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
45 MAPK10suppressor40.6670.105Pkinase (PF00069, IPR000719): Protein kinase domain
46 MAPK8oncoprotein110.7336.733DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
47 MC1Rinteractor50.5004.1677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7tm_4 (PF13853): Olfactory receptor
48 MCCsuppressor21.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
FAM76 (PF16046, IPR032017): FAM76 protein
49 MCM2oncoprotein190.43148.636AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
50 MDM2oncoprotein60.4003.952Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
51 MPP3interactor21.0000L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
52 MSNoncoprotein430.152595.120DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
53 NF2suppressor90.32113.067ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
54 NOLC1interactor40.8330.182DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain
Stm1_N (PF09598, IPR019084): Stm1
stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
PAF (PF15715, IPR031444): PCNA-associated factor
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NuDC (PF16273, IPR032572): Nuclear distribution C domain
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
55 NTRK1oncoprotein320.209267.890I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
56 OBSL1interactor150.45122.484BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
57 OGFOD1interactor40.6671.667Ofd1_CTDD (PF10637, IPR019601): Oxoglutarate and iron-dependent oxygenase degradation C-term
2OG-FeII_Oxy_4 (PF13661): 2OG-Fe(II) oxygenase superfamily
58 P4HBinteractor140.55115.859Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
59 PDCD10interactor60.4007.667DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
CENP-L (PF13092, IPR025204): Kinetochore complex Sim4 subunit Fta1
60 PDCD6IPinteractor90.5007.138BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
61 PDXKoncoprotein21.0000Phos_pyr_kin (PF08543, IPR013749): Phosphomethylpyrimidine kinase
Staphylokinase (PF02821, IPR004093): Staphylokinase/Streptokinase family
62 PGDoncoprotein50.9000.1056PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
63 PHLPP2suppressor40.5002.167LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PH (PF00169, IPR001849, SM00233): PH domain
PP2C (PF00481, IPR001932): Protein phosphatase 2C
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
64 PIK3R1oncoprotein60.6002.000RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
65 PLS1interactor30.6670.105CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
66 PLS3interactor90.7225.287CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
67 PPLinteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
DivIC (PF04977, IPR007060): Septum formation initiator
MCU (PF04678, IPR006769): Mitochondrial calcium uniporter
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
FliT (PF05400, IPR008622): Flagellar protein FliT
M (PF02370, IPR003345): M protein repeat
Mnd1 (PF03962, IPR005647): Mnd1 family
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spectrin (PF00435, IPR002017): Spectrin repeat
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
68 PRKCAinteractor100.41715.567C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
69 RCN1interactor80.5716.191EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
70 RDXinteractor220.242114.507ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
71 RIC8Ainteractor40.8330.667PUL (PF08324, IPR013535): PUL domain
Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
72 S100Poncoprotein200S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
73 SCYL3interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
74 SELLinteractor30.6670.333EGF (PF00008, IPR000742, SM00181): EGF-like domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
MWFE (PF15879, IPR017384): NADH-ubiquinone oxidoreductase MWFE subunit
75 SELPinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
76 SLC9A3R1suppressor100.41712.561EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
77 SLC9A3R2interactor40.5002.000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
78 SPTA1interactor100EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
79 STIP1interactor170.51528.241TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
80 TAGLN2interactor200.38467.784Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
81 TKTprotein found in more fusions190.49036.219Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
82 TNFRSF10Bsuppressor81.0000Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
83 TNFRSF1Aoncoprotein110.6899.900Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
84 TSC1suppressor31.0000Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Hamartin (PF04388, IPR007483): Hamartin protein
85 TXNRD2interactor21.0000Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
86 U2AF2protein found in more fusions200.40953.931RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
87 UBA1protein found in more fusions150.28650.022ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
88 UBE2R2protein found in more fusions31.0000NOA36 (PF06524, IPR010531): NOA36 protein
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
89 VCAM1interactor120.39424.287C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
90 VPS11interactor40.6670.216DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
VPS11_C (PF12451, IPR024763): Vacuolar protein sorting protein 11 C terminal
TPR_11 (PF13414, IPR011990): TPR repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
91 WDR1interactor80.7502.235eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
92 WWP1oncoprotein200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
93 XPNPEP1interactor80.50010.733Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24
Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ADORA2Binteractor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
GPR_Gpa2_C (PF11970, IPR022596): G protein-coupled glucose receptor regulating Gpa2 C-term
2 AKR1B1suppressorAldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
3 ARHGDIAinteractorRho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
4 ATP1B3interactorNa_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
5 ATXN1LinteractorAXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
6 B4GALT7interactorGlyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase
Glyco_transf_7N (PF13733, IPR027995): N-terminal region of glycosyl transferase group 7
7 BAG3oncoproteinBAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
8 BIDoncoproteinBID (PF06393, IPR010479): BH3 interacting domain (BID)
9 CALRoncoproteinCalreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
10 CLN3interactorCLN3 (PF02487, IPR003492): CLN3 protein
11 DCCsuppressorfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neogenin_C (PF06583, IPR010560): Neogenin C-terminus
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
12 ECE2interactorPeptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
Peptidase_M48 (PF01435, IPR001915): Peptidase family M48
Methyltransf_25 (PF13649): Methyltransferase domain
13 EGFRoncoproteinFurin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 EZRparental proteinDUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
15 FABP5interactorLipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
16 FADS2parental proteinCyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
17 FASLGinteractorPAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
18 FBXO6interactorFBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
19 FN1oncoproteinfn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
20 GABARAPL2interactorAtg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
21 GDI2interactorGDI (PF00996, IPR018203): GDP dissociation inhibitor
22 GNPDA1interactorGlucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
23 H2AFZinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
24 HSD17B10interactoradh_short (PF00106, IPR002198): short chain dehydrogenase
25 HSPA4LinteractorHSP70 (PF00012, IPR013126): Hsp70 protein
26 HSPE1interactorCpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
27 ISG15suppressorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
28 ISYNA1interactorNAD_binding_5 (PF07994, IPR002587): Myo-inositol-1-phosphate synthase
29 OATinteractorAminotran_3 (PF00202, IPR005814): Aminotransferase class-III
30 PALLDinteractorI-set (PF07679, IPR013098): Immunoglobulin I-set domain
31 PPA2interactorPyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
32 PPME1interactorAbhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
33 PRKAB1oncoproteinAMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
34 PRXinteractorCornifin (PF02389, IPR003302): Cornifin (SPRR) family
CCDC74_C (PF14917, IPR029422): Coiled coil protein 74, C terminal
35 PTK2interactorFERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
36 PTTG1oncoproteinSecurin (PF04856, IPR006940): Securin sister-chromatid separation inhibitor
37 PYGLinteractorPhosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
38 RHOAsuppressorRas (PF00071, IPR001806, SM00173): Ras family
39 SCARNA22interactorNA
40 SDC2interactorGlycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
41 SHMT2interactorSHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
42 SPNinteractorBatA (PF07584, IPR024163): Aerotolerance regulator N-terminal
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
43 TCTN2interactorDUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
44 TCTN3interactorDUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
45 TIMM13interactorzf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
46 TPD52oncoproteinTPD52 (PF04201, IPR007327): Tumour protein D52 family
47 TPD52L2interactorTPD52 (PF04201, IPR007327): Tumour protein D52 family
48 TRNT1interactorPolyA_pol (PF01743, IPR002646): Poly A polymerase head domain
PolyA_pol_RNAbd (PF12627, IPR032828): Probable RNA and SrmB- binding site of polymerase A
49 UCHL3interactorPeptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
50 VSIG4interactorEMP70 (PF02990, IPR004240): Endomembrane protein 70
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
51 WFDC1suppressorWAP (PF00095, IPR008197, SM00217): WAP-type (Whey Acidic Protein) 'four-disulfide core'
MDMPI_N (PF11716, IPR024344): Mycothiol maleylpyruvate isomerase N-terminal domain

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