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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BQ063625 is the fusion of parental proteins TUFM, RNF40 (from a repository: Thu Dec 8 11:30:08 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)214
The number (and %) of the onco-proteins51 (23.83 %)
The number (and %) of the tumor suppressors20 (9.35 %)
Total number of binary PPIs (saturation %)2445 (10.73 %)
The number (and %) of affected PPIs213 (8.71 %)
The number of possible different fusions34
PPI diameter2
PPI radius1
The average degree of PPI22.196
Assortativity coefficient-0.1358
The network average Clustering coefficient0.498
The number (and %) of a zero Clustering coefficients11 (5.14 %)
The number (and %) of a zero Betweenness Centrality20 (9.35 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: RNF40,TUFM All fusions
: BQ063625;
Proteins found in more fusions GRK5 (see 4 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); WAC (see 3 fusions); ARF1 (see 2 fusions); EWSR1 (see 2 fusions); RPS5/RPL14 (see 1 fusions); AMOTL2 (see 1 fusions); HDAC5 (see 1 fusions); UBE2E1 (see 2 fusions); ZNF451 (see 1 fusions); SUZ12 (see 2 fusions); PTBP1 (see 1 fusions); RPS24/RPS23 (see 1 fusions); HSP90AA1 (see 2 fusions); HUWE1 (see 2 fusions); ERBB3 (see 2 fusions); FMNL1 (see 1 fusions); UBE2L6 (see 2 fusions); GAPDH (see 2 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); SNAP29 (see 1 fusions); SKI (see 1 fusions); COPS5 (see 1 fusions); UBC (see 1 fusions); CLU (see 5 fusions); CRY2 (see 3 fusions); SGK1 (see 2 fusions); HNRNPL (see 2 fusions); MCM2 (see 1 fusions); FN1/RPL6 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BQ063625chimera2130.09625751.308BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EzrA (PF06160, IPR010379): Septation ring formation regulator, EzrA
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SpoIIE (PF07228, IPR001932): Stage II sporulation protein E (SpoIIE)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
2 ADRB2interactor190.30146.0847tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
3 AGO4interactor80.5361.771ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
4 AK2interactor60.8670.533ADK (PF00406, IPR000850): Adenylate kinase
AAA_33 (PF13671): AAA domain
5 AMOTL2protein found in more fusions40.6670.333HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
6 ARoncoprotein150.33031.512Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
7 ARF1suppressor100.3616.884Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
8 ARL6IP1interactor200Reticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
9 ASB10interactor60.4003.535Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
10 ASB12interactor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
SOCS_box (PF07525, IPR001496): SOCS box
11 ASB14interactor50.6000.727Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
12 ASB17interactor40.5000.414HTH_Mga (PF08280, IPR013199): M protein trans-acting positive regulator (MGA) HTH domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
SOCS_box (PF07525, IPR001496): SOCS box
13 ASLoncoprotein31.0000Lyase_1 (PF00206, IPR022761): Lyase
ASL_C2 (PF14698, IPR029419): Argininosuccinate lyase C-terminal
T4SS_CagC (PF16943, IPR031607): Cag pathogenicity island, type IV secretory system
14 ATMsuppressor100.4447.789FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
15 BANF1interactor200BAF (PF02961, IPR004122, SM01023): Barrier to autointegration factor
16 BMI1oncoprotein180.31641.352zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
17 BORCS6interactor100DUF2365 (PF10157, IPR019314): Uncharacterized conserved protein (DUF2365)
18 C1QBPinteractor350.264159.865MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
19 CAMK1Dinteractor60.6003.281Pkinase (PF00069, IPR000719): Protein kinase domain
Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
20 CANXinteractor300.345102.432Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
21 CAPN2interactor110.52711.461Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
22 CCDC146interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
23 CCDC8interactor330.44869.166Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
24 CD81interactor220.55725.779Tetraspannin (PF00335, IPR018499): Tetraspanin family
25 CDC73suppressor90.5837.319CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
26 CDK2suppressor500.424258.724Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
27 CDK9protein found in more fusions190.30170.061Pkinase (PF00069, IPR000719): Protein kinase domain
28 CHMP7interactor40.8330.333Snf7 (PF03357, IPR005024): Snf7
29 CIAPIN1interactor80.4298.133CIAPIN1 (PF05093, IPR007785): Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Methyltransf_31 (PF13847, IPR025714): Methyltransferase domain
30 CLTConcoprotein340.339118.185Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
31 CLUsuppressor100.5282.993Clusterin (PF01093, IPR000753): Clusterin
32 CMTM5suppressor100MARVEL (PF01284, IPR008253): Membrane-associating domain
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
33 CMTR1interactor40.8330.250FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
G-patch (PF01585, IPR000467, SM00443): G-patch domain
mRNA_cap_enzyme (PF01331, IPR001339): mRNA capping enzyme, catalytic domain
WW (PF00397, IPR001202, SM00456): WW domain
34 COPS5protein found in more fusions590.493203.665JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
35 CRY2protein found in more fusions110.6003.524DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
36 CUL2suppressor480.492205.325Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
37 CUL3protein found in more fusions780.301962.975Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
38 CUL4Boncoprotein410.56098.129Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
39 CUL5suppressor430.535135.772Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
40 CUL7protein found in more fusions460.402181.801ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
41 DCPSinteractor90.5288.945DcpS (PF05652, IPR008594): Scavenger mRNA decapping enzyme (DcpS) N-terminal
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
42 DDOSTinteractor160.5839.119DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
43 DSN1interactor40.6670.619MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
44 ENGinteractor200Zona_pellucida (PF00100, IPR001507, SM00241): Zona pellucida-like domain
45 ERBB3oncoprotein100.3899.489Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
46 ESR1suppressor490.475196.634Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
47 ESRRBsuppressor120.4855.902zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
48 EWSR1oncoprotein400.302261.598RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
49 EXOSC6interactor60.8000.467RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
50 FAM9Binteractor40.6670.667Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
51 FBXO6interactor290.34294.426FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
52 FCGR3Ainteractor100Ig_2 (PF13895, IPR007110): Immunoglobulin domain
53 FMNL1protein found in more fusions60.6000.612CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
SlyX (PF04102, IPR007236): SlyX
FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
54 FN1oncoprotein500.439187.198fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
55 FUNDC1interactor100FUN14 (PF04930, IPR007014): FUN14 family
56 FUSsuppressor370.48268.438Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
57 GAPDHoncoprotein300.33584.392Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
58 GFM1interactor50.6001.105EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
59 GRK5protein found in more fusions120.32718.427Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
60 GTF2H5interactor21.0000Tfb5 (PF06331, IPR009400): Transcription factor TFIIH complex subunit Tfb5
61 GTF3C4interactor90.38914.013TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
62 HDAC5protein found in more fusions260.44033.261Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
63 HEXBinteractor70.5335.733Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
64 HIP1Rinteractor60.7330.297ANTH (PF07651, IPR011417): ANTH domain
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
65 HIST2H2BEinteractor230.37973.127Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
66 HK1interactor170.27267.332Hexokinase_1 (PF00349, IPR022672): Hexokinase
Hexokinase_2 (PF03727, IPR022673): Hexokinase
67 HNRNPLprotein found in more fusions200.5268.575RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
68 HSP90AA1oncoprotein590.272591.043HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
69 HSPA5oncoprotein490.299331.704HSP70 (PF00012, IPR013126): Hsp70 protein
70 HUWE1oncoprotein500.326300.442BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
71 IARS2interactor60.4003.161Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
72 IER2oncoprotein21.0000IER (PF05760, IPR008653): Immediate early response protein (IER)
MAGI_u1 (PF16663): Unstructured region on MAGI
73 IL36Ainteractor21.0000IL1 (PF00340, IPR000975, SM00125): Interleukin-1 / 18
74 IPO9interactor80.5006.951IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_EZ (PF13513): HEAT-like repeat
75 ITSN1interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
76 IWS1interactor40.6670.800DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
77 KLC3interactor50.5002.000TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TPR_12 (PF13424): Tetratricopeptide repeat
78 KRASoncoprotein140.28236.003Ras (PF00071, IPR001806, SM00173): Ras family
79 LMAN1interactor60.8000.519Lectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
80 MBIPinteractor40.6670.500DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
81 MCM2oncoprotein600.372379.574AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
82 MORC1interactor100FliJ (PF02050, IPR012823): Flagellar FliJ protein
p25-alpha (PF05517, IPR008907): p25-alpha
zf-CW (PF07496, IPR011124): CW-type Zinc Finger
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
83 MRPL1interactor140.59311.476CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
84 MRPL11interactor110.4917.509Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
85 MRPL14interactor110.5647.130Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
RTT107_BRCT_6 (PF16771, IPR031906): Regulator of Ty1 transposition protein 107 BRCT domain
86 MRPL17interactor130.53812.866Ribosomal_L17 (PF01196, IPR000456): Ribosomal protein L17
COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein
87 MRPL18interactor140.58210.674Ribosomal_L18p (PF00861, IPR005484): Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
88 MRPL2interactor170.51522.576Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
89 MRPL22interactor160.48318.318Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
90 MRPL23interactor170.40439.652Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
91 MRPL24interactor200.55322.882KOW (PF00467, IPR005824, SM00739): KOW motif
ribosomal_L24 (PF17136): Ribosomal proteins 50S L24/mitochondrial 39S L24
92 MRPL3interactor120.5917.292Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
93 MRPL4interactor180.47129.138Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
94 MRPL58interactor280.307120.893RF-1 (PF00472, IPR000352): RF-1 domain
95 MRPS10interactor140.45113.841Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
96 MRPS14interactor110.6008.790Ribosomal_S14 (PF00253, IPR001209): Ribosomal protein S14p/S29e
97 MRPS5interactor130.6415.156Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
98 MRPS7interactor220.43749.533DUF454 (PF04304, IPR007401): Protein of unknown function (DUF454)
Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
99 MSL1interactor70.7142.967Herpes_UL6 (PF01763, IPR002660): Herpesvirus UL6 like
KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein
PEHE (PF15275, IPR029332): PEHE domain
MSL1_dimer (PF16801, IPR031840): Dimerisation domain of Male-specific-Lethal 1
100 MSL2interactor60.9330.400MSL2-CXC (PF16682, IPR032049): CXC domain of E3 ubiquitin-protein ligase MSL2
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
101 NACA2interactor51.0000NAC (PF01849, IPR002715): NAC domain
102 NAE1interactor120.45522.671ThiF (PF00899, IPR000594): ThiF family
103 NCBP1interactor170.34625.124MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
MIF4G_like (PF09088, IPR015172): MIF4G like
MIF4G_like_2 (PF09090, IPR015174): MIF4G like
SlyX (PF04102, IPR007236): SlyX
104 NENFinteractor130.46220.256Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
105 NOP56interactor400.69468.800Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
106 NOTCH1suppressor70.4004.087Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
107 NPM1suppressor740.406508.822Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
108 NSFL1Cinteractor120.50018.682SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
109 NTRK1oncoprotein790.2031370.583I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
110 NXF1interactor460.198447.293NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
111 OBSL1interactor370.43285.008BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
112 OIP5interactor50.5003.733Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
113 PAF1oncoprotein100.53313.233Paf1 (PF03985, IPR007133): Paf1
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
114 PAFAH1B2oncoprotein80.4297.468Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
115 PAN2interactor320.8438.456RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
116 PARK2suppressor290.328104.038IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
117 PCinteractor120.48515.941Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
HMGL-like (PF00682, IPR000891): HMGL-like
PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
118 PDIA4interactor150.34335.369Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
119 PHB2interactor260.249112.347DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
120 PLAAinteractor90.6115.810PFU (PF09070, IPR015155): PFU (PLAA family ubiquitin binding)
PUL (PF08324, IPR013535): PUL domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
121 PLCG1oncoprotein80.3938.174C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
122 PLEKHO2interactor21.0000PH (PF00169, IPR001849, SM00233): PH domain
123 POLR3Ainteractor110.45512.942RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
124 PPP1R2interactor90.41715.900IPP-2 (PF04979, IPR007062): Protein phosphatase inhibitor 2 (IPP-2)
125 PPP2R2Binteractor40.5002.048WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
126 PPP5Cinteractor110.50912.278Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PPP5 (PF08321, IPR013235): PPP5 TPR repeat region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
127 PPT2interactor120.39418.051Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
128 PRKCDBPsuppressor80.4296.416A1_Propeptide (PF07966, IPR012848): A1 Propeptide
PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
129 PROSCinteractor110.43620.157Ala_racemase_N (PF01168, IPR001608): Alanine racemase, N-terminal domain
130 PTBP1oncoprotein280.45647.946RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
131 PTENsuppressor240.41377.126DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
132 RAB5Boncoprotein80.4647.734Ras (PF00071, IPR001806, SM00173): Ras family
133 RB1suppressor100.40012.127RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
134 RNF2interactor440.306267.935zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
135 RNF20interactor280.171241.598Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein
Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
136 RPL11suppressor530.642106.979Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5
Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
137 RPL12interactor540.62594.143Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
138 RPL14protein found in more fusions530.64480.529KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
139 RPL15interactor470.76422.952Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15
140 RPL17interactor480.68265.899Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
141 RPL19interactor460.75530.988DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e
142 RPL23interactor550.529259.502Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
143 RPL23Ainteractor540.643102.172Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
144 RPL3interactor560.624115.961Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
145 RPL31interactor440.76324.212Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e
146 RPL32interactor380.77234.910Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
147 RPL37Ainteractor380.8926.996Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
148 RPL6protein found in more fusions580.586118.080Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e
Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
149 RPL7interactor550.64393.559Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e
Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
150 RPL8interactor600.562153.499Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
151 RPL9interactor520.657107.930Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
152 RPN1oncoprotein280.31093.091Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
153 RPS11interactor470.71051.732Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17
Ribosomal_S17_N (PF16205, IPR032440): Ribosomal_S17 N-terminal
154 RPS13interactor490.70953.464Ribosomal_S13_N (PF08069, IPR012606): Ribosomal S13/S15 N-terminal domain
Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
155 RPS15Ainteractor510.65287.978Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
156 RPS16interactor570.589170.026Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
157 RPS2interactor630.509228.234Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
158 RPS20interactor500.66584.387Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
159 RPS23protein found in more fusions420.78935.256Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
160 RPS24protein found in more fusions460.76523.406Fascin (PF06268, IPR022768): Fascin domain
Ribosomal_S24e (PF01282, IPR001976): Ribosomal protein S24e
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
161 RPS26interactor420.71369.861Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
162 RPS3interactor620.550171.513KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
163 RPS5protein found in more fusions560.530205.202Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
164 RPS6interactor550.62098.880Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
165 RPS6KB2interactor190.57911.001Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
166 RPS8interactor720.442418.416Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
167 SARS2interactor100.33316.886tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
DUF2312 (PF10073, IPR018753): Uncharacterized protein conserved in bacteria (DUF2312)
DUF4445 (PF14574, IPR027980): Domain of unknown function (DUF4445)
168 SEPHS1interactor50.6670.595AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
169 SEPT2oncoprotein70.6670.676FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
170 SFR1interactor100Mei5 (PF10376, IPR018468): Double-strand recombination repair protein
171 SFXN3interactor40.6670.189Mtc (PF03820, IPR004686): Tricarboxylate carrier
172 SGK1oncoprotein40.6670.100Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
173 SIRT6suppressor60.4674.617SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
174 SIRT7interactor380.411148.722DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
175 SKIoncoprotein130.37914.673c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
176 SLC25A3interactor300.303111.831Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
177 SMURF1interactor230.55416.914C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
178 SNAP29protein found in more fusions80.38110.221DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
179 SNCGoncoprotein40.5001.833Synuclein (PF01387, IPR001058): Synuclein
180 SNX2interactor50.5001.527PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
181 SPRTNinteractor60.6671.848GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
182 STX1Ainteractor40.6671.000Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
4HB_MCP_1 (PF12729, IPR024478): Four helix bundle sensory module for signal transduction
183 SUPT6Hinteractor80.3218.670Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Tex_N (PF09371, IPR018974): Tex-like protein N-terminal domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SH2_2 (PF14633, IPR000980): SH2 domain
HHH_7 (PF14635, IPR032706): Helix-hairpin-helix motif
YqgF (PF14639, IPR028231): Holliday-junction resolvase-like of SPT6
HTH_44 (PF14641, IPR028088): Helix-turn-helix DNA-binding domain of SPT6
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
DLD (PF14878, IPR027999): Death-like domain of SPT6
184 SUZ12suppressor160.41917.164DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
185 TALDO1interactor80.5363.109TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
186 TERF1interactor180.38238.663TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
187 TERF2interactor130.37917.092Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
188 TRABDinteractor21.0000TraB (PF01963, IPR002816): TraB family
189 TRIM51interactor100CCT_2 (PF09425, IPR018467): Divergent CCT motif
RRF (PF01765, IPR023584): Ribosome recycling factor
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Tubulin_3 (PF14881, IPR029209): Tubulin domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
190 TSSK1Binteractor30.6670.250Pkinase (PF00069, IPR000719): Protein kinase domain
191 TUBB2Ainteractor180.28149.352Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
192 TUBB6interactor160.19240.965Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
193 TXNDC5interactor80.4295.883Thioredoxin (PF00085, IPR013766): Thioredoxin
194 U2AF2protein found in more fusions360.387121.067RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
195 UBCprotein found in more fusions520.265518.152ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
196 UBE2Ainteractor110.46713.882UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
197 UBE2Binteractor70.7332.067UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
198 UBE2E1protein found in more fusions80.3336.322UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
199 UBE2Iinteractor230.26890.877UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
200 UBE2L6protein found in more fusions40.6670.118UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
201 UBE2Sinteractor50.6670.686ALF (PF03752, IPR005506): Short repeats of unknown function
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
202 UBL4Ainteractor450.483128.705ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
203 UBXN1interactor210.35363.935Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
204 UQCRC2oncoprotein190.42138.724Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
205 USP15oncoprotein190.39242.577UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
206 VCAM1interactor380.471108.958C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
207 WACprotein found in more fusions80.4768.733DUF1319 (PF07028, IPR010746): Protein of unknown function (DUF1319)
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
WW (PF00397, IPR001202, SM00456): WW domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
208 WDR12interactor100.41710.941NLE (PF08154, IPR012972): NLE (NUC135) domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
209 WDR61interactor80.3938.025WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
210 WNT4interactor30.6670.333MEF2_binding (PF09047, IPR015134): MEF2 binding
wnt (PF00110, IPR005817, SM00097): wnt family
211 XPNPEP1interactor80.5366.783Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24
Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain
212 XPO1interactor510.252583.109CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
213 ZNF451protein found in more fusions50.6670.619zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Cys_rich_KTR (PF14205, IPR025957): Cysteine-rich KTR
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
214 ZSWIM7interactor30.6670.118DUF1294 (PF06961, IPR010718): Protein of unknown function (DUF1294)
SWIM (PF04434, IPR007527): SWIM zinc finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 RNF40parental proteinBRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EzrA (PF06160, IPR010379): Septation ring formation regulator, EzrA
FlgN (PF05130, IPR007809): FlgN protein
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SpoIIE (PF07228, IPR001932): Stage II sporulation protein E (SpoIIE)
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
2 TUFMparental proteinGTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain

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