1 |
BP429816 | chimera | 150 | 0.112 | 11240.006 | PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain |
2 |
ACAT2 | protein found in more fusions | 7 | 0.400 | 3.401 | Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain |
3 |
AGL | interactor | 6 | 0.933 | 0.087 | GDE_C (PF06202, IPR010401): Amylo-alpha-1,6-glucosidase hGDE_N (PF14699, IPR029436): N-terminal domain from the human glycogen debranching enzyme hDGE_amylase (PF14701, IPR032792): Glycogen debranching enzyme, glucanotransferase domain hGDE_central (PF14702, IPR032788): Central domain of human glycogen debranching enzyme |
4 |
AKR1A1 | interactor | 9 | 0.639 | 2.982 | Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family |
5 |
AMDHD2 | interactor | 1 | 0 | 0 | Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family |
6 |
ANP32A | suppressor | 8 | 0.679 | 3.221 | SDA1 (PF05285, IPR007949): SDA1 LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_9 (PF14580): Leucine-rich repeat |
7 |
APP | protein found in more fusions | 35 | 0.239 | 244.039 | APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein |
8 |
ARAF | oncoprotein | 8 | 0.571 | 3.878 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
9 |
ARRB1 | interactor | 14 | 0.593 | 6.356 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
10 |
ARRB2 | interactor | 21 | 0.481 | 29.302 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
11 |
ASS1 | suppressor | 16 | 0.400 | 24.777 | Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase |
12 |
ATF2 | oncoprotein | 21 | 0.295 | 52.135 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type |
13 |
BANF1 | interactor | 3 | 1.000 | 0 | BAF (PF02961, IPR004122, SM01023): Barrier to autointegration factor |
14 |
C9orf64 | interactor | 3 | 0.667 | 0.222 | Q_salvage (PF10343, IPR019438): Potential Queuosine, Q, salvage protein family |
15 |
CAPZA2 | interactor | 12 | 0.348 | 23.356 | F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit |
16 |
CBS | protein found in more fusions | 12 | 0.618 | 10.350 | CBS (PF00571, IPR000644, SM00116): CBS domain DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414) PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme |
17 |
CCDC8 | interactor | 24 | 0.443 | 46.299 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA |
18 |
CCDC88A | protein found in more fusions | 4 | 1.000 | 0 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor ZapB (PF06005, IPR009252): Cell division protein ZapB DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) HOOK (PF05622, IPR008636): HOOK protein Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2 KxDL (PF10241, IPR019371): Uncharacterized conserved protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain |
19 |
CD81 | interactor | 21 | 0.447 | 25.289 | Tetraspannin (PF00335, IPR018499): Tetraspanin family |
20 |
CDC37 | protein found in more fusions | 23 | 0.437 | 42.185 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
21 |
CDK2 | suppressor | 39 | 0.326 | 160.266 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
22 |
CFL1 | interactor | 38 | 0.303 | 215.433 | Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein |
23 |
CRY1 | interactor | 12 | 0.545 | 4.191 | DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase |
24 |
CTPS1 | interactor | 13 | 0.576 | 3.577 | CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus GATase (PF00117, IPR017926): Glutamine amidotransferase class-I |
25 |
CUL1 | suppressor | 38 | 0.378 | 137.331 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
26 |
CUL2 | suppressor | 28 | 0.439 | 61.382 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
27 |
CUL3 | protein found in more fusions | 51 | 0.280 | 366.061 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
28 |
CUL5 | suppressor | 28 | 0.492 | 46.980 | Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
29 |
CUL7 | protein found in more fusions | 38 | 0.336 | 126.279 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
30 |
DAZAP1 | interactor | 22 | 0.355 | 53.465 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) |
31 |
DNAJA3 | suppressor | 7 | 0.667 | 1.737 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain |
32 |
EEF1A1 | suppressor | 56 | 0.280 | 485.540 | GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain |
33 |
EEF1A2 | oncoprotein | 17 | 0.324 | 26.468 | GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain |
34 |
EEF1D | protein found in more fusions | 28 | 0.399 | 58.346 | EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region |
35 |
EGLN1 | suppressor | 4 | 1.000 | 0 | zf-MYND (PF01753, IPR002893): MYND finger 2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily |
36 |
EGLN3 | suppressor | 5 | 0.667 | 1.500 | 2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily |
37 |
EIF4A3 | interactor | 27 | 0.394 | 68.231 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
38 |
ENO3 | interactor | 8 | 0.607 | 6.055 | Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain |
39 |
EP300 | oncoprotein | 20 | 0.304 | 68.753 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type |
40 |
EPM2A | interactor | 2 | 0 | 0 | CBM_20 (PF00686, IPR002044): Starch binding domain DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain |
41 |
ETS1 | oncoprotein | 6 | 0.533 | 3.336 | Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain |
42 |
EWSR1 | oncoprotein | 34 | 0.383 | 103.314 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
43 |
EXOSC5 | interactor | 3 | 0.667 | 0.125 | RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1 RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2 |
44 |
EZH2 | suppressor | 19 | 0.405 | 33.496 | CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal |
45 |
FAM49B | interactor | 2 | 1.000 | 0 | DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) |
46 |
FBXO6 | interactor | 31 | 0.338 | 101.363 | FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like |
47 |
FGFR1 | oncoprotein | 3 | 1.000 | 0 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
48 |
FH | suppressor | 13 | 0.410 | 24.399 | Lyase_1 (PF00206, IPR022761): Lyase FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus |
49 |
FN1 | oncoprotein | 44 | 0.280 | 230.452 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
50 |
FUBP1 | oncoprotein | 17 | 0.382 | 18.481 | DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897) KH_1 (PF00013, IPR004088, SM00322): KH domain CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance |
51 |
FUS | suppressor | 37 | 0.465 | 101.510 | Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
52 |
GAPDH | oncoprotein | 50 | 0.324 | 277.161 | Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein |
53 |
GNG12 | interactor | 2 | 1.000 | 0 | G-gamma (PF00631, IPR015898, SM00224): GGL domain |
54 |
GRB7 | interactor | 2 | 1.000 | 0 | BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain |
55 |
H2AFX | suppressor | 19 | 0.444 | 23.053 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A |
56 |
HDAC5 | protein found in more fusions | 23 | 0.385 | 30.945 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
57 |
HDAC6 | oncoprotein | 19 | 0.373 | 36.896 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein |
58 |
HERC1 | protein found in more fusions | 3 | 1.000 | 0 | Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Presenilin (PF01080, IPR001108): Presenilin RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat SPRY (PF00622, IPR003877, SM00449): SPRY domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat |
59 |
HIF1A | suppressor | 14 | 0.407 | 30.958 | Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1 |
60 |
HLA-DRA | interactor | 5 | 1.000 | 0 | MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain C1-set_C (PF16196, IPR032431): C1-set C-terminal domain |
61 |
HLA-DRB1 | interactor | 8 | 0.762 | 2.500 | DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain |
62 |
HLA-DRB3 | interactor | 4 | 1.000 | 0 | DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain |
63 |
HLA-DRB4 | interactor | 3 | 1.000 | 0 | DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain |
64 |
HLA-DRB5 | interactor | 5 | 1.000 | 0 | MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain |
65 |
HNRNPA1 | interactor | 43 | 0.454 | 96.274 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1 |
66 |
HNRNPD | oncoprotein | 32 | 0.376 | 92.793 | CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head |
67 |
HNRNPK | oncoprotein | 38 | 0.405 | 117.118 | ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain |
68 |
HSP90AA1 | oncoprotein | 57 | 0.258 | 548.432 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
69 |
HSP90AB1 | oncoprotein | 51 | 0.298 | 341.681 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
70 |
HSPB1 | oncoprotein | 32 | 0.383 | 95.576 | HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family |
71 |
HUWE1 | oncoprotein | 33 | 0.365 | 96.678 | BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) |
72 |
IGSF8 | oncoprotein | 15 | 0.419 | 18.399 | V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
73 |
IKBKAP | interactor | 7 | 0.400 | 3.530 | IKI3 (PF04762, IPR006849): IKI3 family Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis |
74 |
IPO11 | interactor | 8 | 0.500 | 5.526 | DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein HEAT_2 (PF13646): HEAT repeats |
75 |
IQCB1 | interactor | 16 | 0.417 | 41.979 | DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765) IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit |
76 |
ISG15 | suppressor | 15 | 0.457 | 11.548 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
77 |
ITGA4 | interactor | 34 | 0.360 | 92.680 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha |
78 |
LDHA | interactor | 35 | 0.365 | 122.565 | Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain |
79 |
LDHAL6A | interactor | 3 | 0.667 | 0.667 | Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain |
80 |
LDHB | interactor | 25 | 0.428 | 48.090 | Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain |
81 |
LMO7 | oncoprotein | 6 | 0.600 | 1.693 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF2072 (PF09845, IPR018645): Zn-ribbon containing protein AAA_23 (PF13476): AAA domain DUF4757 (PF15949, IPR031865): Domain of unknown function (DUF4757) |
82 |
LNX1 | interactor | 10 | 0.361 | 15.310 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
83 |
LYPLA2 | interactor | 6 | 0.800 | 0.543 | Abhydrolase_2 (PF02230, IPR003140): Phospholipase/Carboxylesterase |
84 |
MAPK7 | oncoprotein | 13 | 0.500 | 18.829 | Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor |
85 |
MCM2 | oncoprotein | 53 | 0.344 | 281.710 | AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
86 |
MCM5 | oncoprotein | 24 | 0.467 | 34.916 | MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
87 |
MDM2 | oncoprotein | 30 | 0.328 | 108.544 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
88 |
ME1 | interactor | 2 | 1.000 | 0 | malic (PF00390, IPR012301): Malic enzyme, N-terminal domain Malic_M (PF03949, IPR012302, SM00919): Malic enzyme, NAD binding domain |
89 |
MGMT | interactor | 8 | 0.714 | 1.695 | DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain |
90 |
MPG | interactor | 4 | 0.667 | 1.000 | Pur_DNA_glyco (PF02245, IPR003180): Methylpurine-DNA glycosylase (MPG) |
91 |
MYOC | interactor | 8 | 0.714 | 1.141 | IncA (PF04156, IPR007285): IncA protein OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain |
92 |
NAGK | protein found in more fusions | 4 | 0.667 | 0.667 | BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family |
93 |
NANS | interactor | 11 | 0.455 | 10.959 | NeuB (PF03102, IPR013132): NeuB family SAF (PF08666, IPR013974, SM00858): SAF domain |
94 |
NDRG1 | suppressor | 8 | 0.500 | 6.392 | Ndr (PF03096, IPR004142): Ndr family |
95 |
NLK | protein found in more fusions | 4 | 1.000 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit |
96 |
NPLOC4 | interactor | 16 | 0.450 | 32.014 | NPL4 (PF05021, IPR007717): NPL4 family zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4 |
97 |
NPM1 | suppressor | 49 | 0.340 | 261.865 | Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain |
98 |
NTRK1 | oncoprotein | 68 | 0.237 | 821.157 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
99 |
NXT2 | interactor | 3 | 1.000 | 0 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain |
100 |
OBSL1 | protein found in more fusions | 30 | 0.414 | 57.853 | BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
101 |
PAICS | interactor | 20 | 0.439 | 33.682 | AIRC (PF00731, IPR000031, SM01001): AIR carboxylase SAICAR_synt (PF01259, IPR028923): SAICAR synthetase |
102 |
PAN2 | interactor | 14 | 0.341 | 33.641 | RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain |
103 |
PAX8 | oncoprotein | 2 | 1.000 | 0 | PAX (PF00292, IPR001523, SM00351): 'Paired box' domain Pax2_C (PF12403, IPR022130): Paired-box protein 2 C terminal |
104 |
PCBP1 | oncoprotein | 39 | 0.340 | 189.052 | Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain |
105 |
PDLIM5 | interactor | 13 | 0.577 | 13.985 | LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749) |
106 |
PFKL | protein found in more fusions | 16 | 0.438 | 15.222 | PFK (PF00365, IPR000023): Phosphofructokinase |
107 |
PFKM | protein found in more fusions | 10 | 0.611 | 4.341 | PFK (PF00365, IPR000023): Phosphofructokinase |
108 |
PFKP | interactor | 18 | 0.431 | 22.852 | PFK (PF00365, IPR000023): Phosphofructokinase Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate |
109 |
PGK1 | interactor | 31 | 0.441 | 81.828 | PGK (PF00162, IPR001576): Phosphoglycerate kinase |
110 |
PIN1 | suppressor | 13 | 0.372 | 19.399 | Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain |
111 |
PLIN3 | interactor | 13 | 0.561 | 13.454 | Perilipin (PF03036, IPR004279): Perilipin family |
112 |
PML | suppressor | 18 | 0.390 | 33.281 | zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
113 |
POLE2 | interactor | 2 | 1.000 | 0 | DNA_pol_E_B (PF04042, IPR007185): DNA polymerase alpha/epsilon subunit B Dpoe2NT (PF12213, IPR024639): DNA polymerases epsilon N terminal |
114 |
PPID | interactor | 10 | 0.733 | 3.080 | Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat |
115 |
PPME1 | protein found in more fusions | 8 | 0.714 | 0.807 | Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family |
116 |
PPP1CA | suppressor | 16 | 0.275 | 20.081 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
117 |
PRDX2 | interactor | 22 | 0.390 | 43.422 | AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin |
118 |
PRDX6 | protein found in more fusions | 19 | 0.340 | 24.670 | AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin |
119 |
PSMA3 | interactor | 27 | 0.437 | 70.511 | Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
120 |
PTEN | suppressor | 10 | 0.289 | 10.802 | DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein |
121 |
RAD23B | suppressor | 16 | 0.392 | 39.829 | K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123) |
122 |
RAF1 | oncoprotein | 12 | 0.473 | 9.712 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
123 |
RCC1 | interactor | 7 | 0.571 | 1.598 | RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat |
124 |
RELA | oncoprotein | 16 | 0.448 | 21.685 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain |
125 |
RPN1 | oncoprotein | 11 | 0.509 | 3.861 | Ribophorin_I (PF04597, IPR007676): Ribophorin I CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain |
126 |
RPP14 | interactor | 1 | 0 | 0 | RNase_P_Rpp14 (PF01900, IPR002759): Rpp14/Pop5 family |
127 |
SHBG | oncoprotein | 3 | 1.000 | 0 | Laminin_G_1 (PF00054, IPR001791): Laminin G domain Laminin_G_2 (PF02210, IPR001791): Laminin G domain |
128 |
SLC3A2 | interactor | 11 | 0.600 | 3.417 | Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain DUF3459 (PF11941, IPR022567): Domain of unknown function (DUF3459) SLC3A2_N (PF16028, IPR031984): Solute carrier family 3 member 2 N-terminus |
129 |
SMN1 | interactor | 13 | 0.545 | 9.096 | SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) |
130 |
SRP14 | interactor | 15 | 0.381 | 29.055 | SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein |
131 |
STAU1 | protein found in more fusions | 27 | 0.483 | 32.997 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain |
132 |
SUMO1 | interactor | 11 | 0.467 | 9.186 | Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like |
133 |
SUZ12 | suppressor | 17 | 0.375 | 32.552 | DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein |
134 |
TERF1 | interactor | 21 | 0.358 | 42.463 | TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
135 |
TINF2 | interactor | 9 | 0.571 | 1.732 | TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus |
136 |
TK1 | oncoprotein | 7 | 0.600 | 1.627 | TK (PF00265, IPR001267, SM00203): Thymidine kinase |
137 |
TKT | protein found in more fusions | 33 | 0.349 | 127.075 | Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain |
138 |
TRAF3IP1 | interactor | 8 | 0.679 | 1.400 | MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 |
139 |
TRAP1 | oncoprotein | 18 | 0.366 | 28.480 | HSP90 (PF00183, IPR001404): Hsp90 protein HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase |
140 |
TRIM35 | suppressor | 2 | 1.000 | 0 | SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain DUF3410 (PF11890, IPR024531): Domain of unknown function (DUF3410) zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
141 |
TRIM63 | interactor | 6 | 0.600 | 2.352 | DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) KIP1 (PF07765, IPR011684): KIP1-like protein RED_C (PF07807, IPR012492): RED-like protein C-terminal region zf-HIT (PF04438, IPR007529): HIT zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module' |
142 |
TUBA4A | interactor | 21 | 0.390 | 37.168 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
143 |
TUBB | interactor | 38 | 0.341 | 142.072 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
144 |
TWF2 | interactor | 3 | 0.667 | 1.000 | Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein |
145 |
U2AF2 | protein found in more fusions | 38 | 0.405 | 110.356 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein |
146 |
UBA2 | interactor | 11 | 0.582 | 11.887 | ThiF (PF00899, IPR000594): ThiF family UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus |
147 |
UCHL5 | oncoprotein | 13 | 0.424 | 16.259 | Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1 |
148 |
UFM1 | interactor | 8 | 0.393 | 9.233 | Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein |
149 |
USP7 | oncoprotein | 22 | 0.290 | 66.424 | MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal |
150 |
VCP | protein found in more fusions | 46 | 0.335 | 238.525 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944) |
151 |
YWHAQ | interactor | 39 | 0.408 | 133.556 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |