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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BP377902 is the fusion of parental proteins HNRNPC, RPL31 (from a repository: Wed Dec 7 18:46:51 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)277
The number (and %) of the onco-proteins76 (27.44 %)
The number (and %) of the tumor suppressors34 (12.27 %)
Total number of binary PPIs (saturation %)7593 (19.86 %)
The number (and %) of affected PPIs276 (3.63 %)
The number of possible different fusions52
PPI diameter2
PPI radius1
The average degree of PPI54.159
Assortativity coefficient-0.0078
The network average Clustering coefficient0.535
The number (and %) of a zero Clustering coefficients3 (1.08 %)
The number (and %) of a zero Betweenness Centrality9 (3.25 %)


List of the fusions

PPI for parental proteins: HNRNPC,RPL31 All fusions
: BP377902;
Proteins found in more fusions U2AF2 (see 2 fusions); VHL (see 1 fusions); EIF2AK2 (see 1 fusions); HNRNPU/RPL24 (see 1 fusions); RPLP2 (see 1 fusions); RPS24/RPS23 (see 1 fusions); RPS24/RPS27 (see 1 fusions); RPL27/RPS6 (see 1 fusions); EEF1A1/RPL12 (see 1 fusions); RPS4X/AHSA1 (see 1 fusions); HNRNPD (see 1 fusions); RPL38/RPL3 (see 1 fusions); CHD4 (see 6 fusions); RPS19/RPS14 (see 1 fusions); TUBG1 (see 1 fusions); EEF1A1 (see 1 fusions); NTRK1/RPL7A (see 1 fusions); CSNK2A1/ELAVL1 (see 1 fusions); CUL3 (see 1 fusions); NAP1L1 (see 3 fusions); IVNS1ABP (see 2 fusions); MYC (see 1 fusions); COPS5 (see 1 fusions); UBC (see 1 fusions); TP53 (see 3 fusions); SH3KBP1 (see 1 fusions); FN1/RPL6 (see 1 fusions); CUL1 (see 3 fusions); GRB2 (see 1 fusions); EWSR1 (see 2 fusions); PRKDC (see 3 fusions); RPS5/RPL14 (see 1 fusions); GAN (see 1 fusions); YWHAZ (see 1 fusions); SMARCC1 (see 2 fusions); SNW1 (see 1 fusions); APP (see 4 fusions); SFPQ (see 6 fusions); SRPK2 (see 1 fusions); SNRNP200 (see 3 fusions); TCF3 (see 4 fusions); CSNK2A1 (see 1 fusions); RBMX (see 3 fusions); STAU1 (see 2 fusions); CUL7 (see 2 fusions); SREK1 (see 4 fusions); PUF60 (see 2 fusions); KHDRBS1 (see 1 fusions); MCM2 (see 1 fusions); RALYL (see 1 fusions); EPS8 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BP377902chimera2760.19021214.402APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
2 AGO4interactor150.7621.430ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
3 AHSA1protein found in more fusions390.65333.829Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
4 AP1M1interactor60.6671.167Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
5 APPprotein found in more fusions650.289439.437APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARRB2interactor610.470149.306Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 ASF1Binteractor70.4761.310ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
8 BANF1interactor60.4001.344BAF (PF02961, IPR004122, SM01023): Barrier to autointegration factor
9 BARD1suppressor280.35075.712BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
10 BLVRBinteractor100NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
11 BRCA1suppressor430.268231.210BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
12 BRCA2suppressor90.6675.062BRCA-2_helical (PF09169, IPR015252): BRCA2, helical
BRCA-2_OB1 (PF09103, IPR015187): BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
BRCA2 (PF00634, IPR002093): BRCA2 repeat
Tower (PF09121, IPR015205): Tower
13 BRINP1suppressor31.0000MACPF (PF01823, IPR020864, SM00457): MAC/Perforin domain
14 BRIP1oncoprotein50.6002.733DEAD_2 (PF06733, IPR010614): DEAD_2
HBB (PF06777, IPR010643): Helical and beta-bridge domain
Helicase_C_2 (PF13307, IPR006555): Helicase C-terminal domain
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
15 BTRConcoprotein250.38045.512WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
16 CACNA1Ainteractor40.5001.722Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
Roughex (PF06020, IPR009259): Drosophila roughex protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
17 CAND1interactor1380.417995.824Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
18 CCDC85Binteractor80.35715.400CCDC85 (PF10226, IPR019359): CCDC85 family
19 CCDC93interactor21.0000Cir_Bir_Yir (PF06022, IPR006477): Plasmodium variant antigen protein Cir/Yir/Bir
Iron_permease (PF04120, IPR007251): Low affinity iron permease
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107)
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
20 CD81interactor460.67532.729Tetraspannin (PF00335, IPR018499): Tetraspanin family
21 CDC5Linteractor830.298693.812OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
22 CDK2suppressor1010.440530.432Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
23 CDKN2Asuppressor200.45312.170Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
24 CEBPAsuppressor130.4246.722Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
25 CELF1interactor50.7000.456RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
26 CEP250interactor630.66371.031ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
27 CEP76interactor280.72030.840Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
CEP76-C2 (PF15627, IPR028926): CEP76 C2 domain
28 CHD4oncoprotein210.36327.629CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SNF2_N (