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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BP367197 is the fusion of parental proteins BMS1, NUCKS1 (from a repository: Sun Jul 5 17:50:00 2020)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins8 (34.78 %)
The number (and %) of the tumor suppressors2 (8.70 %)
Total number of binary PPIs (saturation %)74 (29.25 %)
The number (and %) of affected PPIs22 (29.73 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI5.739
Assortativity coefficient-0.1686
The network average Clustering coefficient0.550
The number (and %) of a zero Clustering coefficients2 (8.70 %)
The number (and %) of a zero Betweenness Centrality5 (21.74 %)


List of the fusions

PPI for parental proteins: NUCKS1,BMS1 All fusions
: BP367197;
Proteins found in more fusions CSNK2A1 (see 1 fusions); RBMX (see 3 fusions); CSNK2A1/ELAVL1 (see 1 fusions); HUWE1 (see 2 fusions); EWSR1 (see 2 fusions); GRK5 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BP367197chimera220.190264.919AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
NOA36 (PF06524, IPR010531): NOA36 protein
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
2 CSNK2A1oncoprotein70.7331.786Pkinase (PF00069, IPR000719): Protein kinase domain
3 ELAVL1oncoprotein70.6003.786RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
4 EWSR1oncoprotein80.4767.952RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
5 FOXM1oncoprotein21.0000EspF (PF04806, IPR006891): EspF protein repeat
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
6 GRK5protein found in more fusions41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
7 HDGFinteractor50.5003.567PWWP (PF00855, IPR000313, SM00293): PWWP domain
8 HIST1H3Einteractor30.6670.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
9 HMGB3interactor30.6670.500HMG_box_2 (PF09011, IPR009071): HMG-box domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
10 HUWE1oncoprotein60.4004.733BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
11 IFI16suppressor50.5003.167HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
12 ILF3oncoprotein70.38111.000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
13 MEX3Cinteractor40.6671.167KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
14 NIFKinteractor50.6002.686RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
15 NXF1interactor110.33325.233NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
16 RBM42interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
17 RBMXsuppressor90.50010.452RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
18 RNF2interactor90.42910.733zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
19 RPSAinteractor50.8000.686Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
20 RRS1interactor40.8330.400GRP (PF07172, IPR010800): Glycine rich protein family
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RRS1 (PF04939, IPR007023): Ribosome biogenesis regulatory protein (RRS1)
21 SHMT2interactor21.0000SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
22 SIRT7interactor100.37820.567DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
23 USP42interactor100TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
AP3D1 (PF06375): AP-3 complex subunit delta-1

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AK5interactorADK (PF00406, IPR000850): Adenylate kinase
Dpy-30 (PF05186, IPR007858): Dpy-30 motif
Zeta_toxin (PF06414, IPR010488): Zeta toxin
AAA_18 (PF13238): AAA domain
2 BMS1parental proteinAARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
E7 (PF00527, IPR000148): E7 protein, Early protein
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
NOA36 (PF06524, IPR010531): NOA36 protein
3 COPS2suppressorYozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
4 GLP1Rinteractor7tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
5 HEXIM1oncoproteinAPG6 (PF04111, IPR007243): Autophagy protein Apg6
DivIC (PF04977, IPR007060): Septum formation initiator
Shugoshin_N (PF07558, IPR011516): Shugoshin N-terminal coiled-coil region
HEXIM (PF15313, IPR024872): Hexamethylene bis-acetamide-inducible protein
6 MMEsuppressorPeptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
7 NUCKS1parental proteinFYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
8 ORC2interactorORC2 (PF04084, IPR007220): Origin recognition complex subunit 2
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
9 PHAXinteractorRNA_GG_bind (PF10258, IPR019385): PHAX RNA-binding domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
10 PRCPinteractorPeptidase_S28 (PF05577, IPR008758): Serine carboxypeptidase S28

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