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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BP350154 is the fusion of parental proteins CDKAL1, CNNM4 (from a repository: Sun Mar 19 03:01:41 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins4 (50.00 %)
The number (and %) of the tumor suppressors1 (12.50 %)
Total number of binary PPIs (saturation %)11 (39.29 %)
The number (and %) of affected PPIs7 (63.64 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.4880
The network average Clustering coefficient0.256
The number (and %) of a zero Clustering coefficients5 (62.50 %)
The number (and %) of a zero Betweenness Centrality7 (87.50 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CNNM4,CDKAL1 All fusions
: BP350154;
Proteins found in more fusions LCK (see 1 fusions); CUL3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BP350154chimera70.04840.000CBS (PF00571, IPR000644, SM00116): CBS domain
DUF21 (PF01595, IPR002550): Domain of unknown function DUF21
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
2 CUL3protein found in more fusions31.0000Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
3 ELAVL1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
4 LCKoncoprotein200Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
5 LRRC39interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
6 PTCH1suppressor100Patched (PF02460, IPR003392): Patched family
7 PTP4A2interactor100Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
8 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CDKAL1parental proteinRadical_SAM (PF04055, IPR007197): Radical SAM superfamily
TRAM (PF01938, IPR002792): TRAM domain
UPF0004 (PF00919, IPR013848): Uncharacterized protein family UPF0004
2 CIAO1interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
3 CNNM4parental proteinCBS (PF00571, IPR000644, SM00116): CBS domain
DUF21 (PF01595, IPR002550): Domain of unknown function DUF21
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
4 EVC2interactorHBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
5 FAF2interactorDUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
6 FAM96BinteractorDUF59 (PF01883, IPR002744): Domain of unknown function DUF59
7 LMNAinteractorFilament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
8 MMS19interactorDUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
9 NEK8interactorPkinase (PF00069, IPR000719): Protein kinase domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
10 SUZ12suppressorDUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
11 TCTN2interactorDUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
12 TCTN3interactorDUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
13 TMEM216interactorTransmemb_17 (PF09799, IPR019184): Predicted membrane protein
14 TMEM237interactorTMEM237 (PF15383, IPR029409): Transmembrane protein 237

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