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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)96
The number (and %) of the onco-proteins23 (23.96 %)
The number (and %) of the tumor suppressors14 (14.58 %)
Total number of binary PPIs (saturation %)309 (6.78 %)
The number (and %) of affected PPIs95 (30.74 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI5.771
Assortativity coefficient-0.3396
The network average Clustering coefficient0.487
The number (and %) of a zero Clustering coefficients20 (20.83 %)
The number (and %) of a zero Betweenness Centrality36 (37.50 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CLU All fusions
: BP348657;
Proteins found in more fusions APP (see 4 fusions); TNF (see 1 fusions); BCL2L1 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); COMMD1 (see 1 fusions); ACTN1 (see 3 fusions); CUL1 (see 3 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); UBC (see 1 fusions); NFKB1 (see 2 fusions); RBBP8 (see 1 fusions); MAPK9 (see 3 fusions); VHL (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BP348657chimera950.0417648.561Clusterin (PF01093, IPR000753): Clusterin
2 ACTN1protein found in more fusions31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
3 ADCYAP1R1interactor1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
4 APOA1interactor60.4005.333ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
5 APPprotein found in more fusions230.139187.587APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARMC6interactor40.6671.667Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Mis14 (PF08641, IPR013950): Kinetochore protein Mis14 like
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
7 ATG3interactor30.6670.333Autophagy_C (PF10381, IPR019461): Autophagocytosis associated protein C-terminal
Autophagy_N (PF03986, IPR007134): Autophagocytosis associated protein (Atg3), N-terminal domain
Autophagy_act_C (PF03987, IPR007135): Autophagocytosis associated protein, active-site domain
8 ATP7Ainteractor30.6671.000E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Fer2_BFD (PF04324, IPR007419): BFD-like [2Fe-2S] binding domain
HMA (PF00403, IPR006121): Heavy-metal-associated domain
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
9 ATP7Binteractor21.0000E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
HMA (PF00403, IPR006121): Heavy-metal-associated domain
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
10 BAG6interactor60.4005.667DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
11 BCL2L1oncoprotein200Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
12 BTRConcoprotein110.51113.700WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
13 C7interactor100MACPF (PF01823, IPR020864, SM00457): MAC/Perforin domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
14 C8Binteractor100MACPF (PF01823, IPR020864, SM00457): MAC/Perforin domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
15 C9interactor100EGF_2 (PF07974, IPR013111): EGF-like domain
MACPF (PF01823, IPR020864, SM00457): MAC/Perforin domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
16 CANXinteractor80.5008.708Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
17 CBY1interactor100Chibby (PF14645, IPR028118): Chibby family
18 CCND3oncoprotein21.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
19 CD209interactor200Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
DGCR6 (PF07324, IPR010849): DiGeorge syndrome critical region 6 (DGCR6) protein
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
20 CDK19interactor100Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
21 CHUKsuppressor90.5718.800Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
22 CLUAP1interactor21.0000DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Tweety (PF04906, IPR006990): Tweety
Cluap1 (PF10234, IPR019366): Clusterin-associated protein-1
SesA (PF17107, IPR031352): N-terminal domain on NACHT_NTPase and P-loop NTPases
23 COMMD1protein found in more fusions80.38112.400COMMD1_N (PF17221): COMMD1 N-terminal domain
COMM_domain (PF07258): COMM domain
24 CUL1suppressor130.37930.319Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25 DISC1interactor40.5002.667HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
26 DOCK6interactor30.6670.250DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
DOCK_N (PF16172, IPR032376): DOCK N-terminus
27 DPPA4interactor50.6671.667Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
DCR (PF14047, IPR025891): Dppa2/4 conserved region
Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
28 EGFRoncoprotein200.22899.936Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
29 ELNoncoprotein100Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen
DUF4169 (PF13770, IPR025227): Domain of unknown function (DUF4169)
30 EPPINinteractor21.0000Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
WAP (PF00095, IPR008197, SM00217): WAP-type (Whey Acidic Protein) 'four-disulfide core'
31 FBXO6interactor110.41817.719FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
32 FXR1interactor200Agenet (PF05641, IPR008395, SM00743): Agenet domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
FXR_C3 (PF16097, IPR032177): Fragile X-related 1 protein C-terminal region 3
33 GPAMinteractor31.0000Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
34 GPR180interactor100GpcrRhopsn4 (PF10192, IPR019336): Rhodopsin-like GPCR transmembrane domain
35 GRB2oncoprotein90.50010.848SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
36 H2AFXsuppressor100.42218.882Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
37 HAX1interactor30.6670.250Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
38 HBA1interactor40.5002.333Globin (PF00042, IPR000971): Globin
39 HLA-DPA1interactor21.0000MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
40 HSP90B1suppressor80.5365.306CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
41 HSPD1suppressor80.5365.952Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
42 HYOU1interactor70.5246.468HSP70 (PF00012, IPR013126): Hsp70 protein
AbiEi_3_N (PF17194): Transcriptional regulator, AbiEi antitoxin N-terminal domain
43 IFNA5interactor21.0000Interferon (PF00143, IPR000471, SM00076): Interferon alpha/beta domain
44 IL20RBinteractor100Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
45 IL24suppressor100IL22 (PF14565, IPR020453): Interleukin 22 IL-10-related T-cell-derived-inducible factor
46 KATNA1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ABC_tran (PF00005, IPR003439): ABC transporter
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_22 (PF13401, IPR003593): AAA domain
47 KEAP1oncoprotein70.6003.650BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
48 KLF11interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
49 KNSTRNinteractor100FlpD (PF02662, IPR003813): Methyl-viologen-reducing hydrogenase, delta subunit
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Matrilin_ccoil (PF10393, IPR019466): Trimeric coiled-coil oligomerisation domain of matrilin
50 LIG4interactor40.5003.000APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
51 LRP2oncoprotein30.6671.000Arylesterase (PF01731, IPR002640): Arylesterase
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Form-deh_trans (PF09163, IPR015246): Formate dehydrogenase N, transmembrane
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
52 LTFsuppressor40.5002.667Transferrin (PF00405, IPR001156, SM00094): Transferrin
53 LYZinteractor30.6670.667Lys (PF00062, IPR001916, SM00263): C-type lysozyme/alpha-lactalbumin family
54 MAPK9suppressor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
55 MCM2oncoprotein190.24884.569AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
56 MDC1suppressor60.4006.800FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
57 MDM2oncoprotein150.28643.702Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
58 MMP25interactor100Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
59 MMP3interactor100Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
60 NFKB1suppressor70.7332.000Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
61 NFKBIAoncoprotein80.6435.467Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
62 NUCB2interactor30.6670.400Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
Histone_HNS (PF00816, IPR001801): H-NS histone family
Peptidase_U57 (PF05582, IPR008764): YabG peptidase U57
Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
63 PAXIP1interactor60.4673.967BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
64 PDGFRAoncoprotein50.6671.667Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
LAT (PF15234, IPR008359): Linker for activation of T-cells
65 PDIA3interactor90.5836.454Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
66 PLK1suppressor80.39314.289Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
67 POLR1Cinteractor40.5001.800RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
68 PON1interactor100Arylesterase (PF01731, IPR002640): Arylesterase
69 PRNPinteractor30.6671.000Prion (PF00377, IPR022416): Prion/Doppel alpha-helical domain
Prion_octapep (PF03991, IPR020949): Copper binding octapeptide repeat
Prion_bPrPp (PF11587, IPR025860): Major prion protein bPrPp - N terminal
70 RAD21oncoprotein50.6003.286Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
71 RASSF7interactor30.6670.667RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SlyX (PF04102, IPR007236): SlyX
Tryp_alpha_amyl (PF00234, IPR016140, SM00499): Protease inhibitor/seed storage/LTP family
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
72 RBBP8suppressor41.0000ZapB (PF06005, IPR009252): Cell division protein ZapB
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
73 RNASE13interactor21.0000RnaseA (PF00074, IPR023412, SM00092): Pancreatic ribonuclease
74 RPEinteractor200OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Ribul_P_3_epim (PF00834, IPR000056): Ribulose-phosphate 3 epimerase family
75 RPL23interactor120.36428.725Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
76 SDF4interactor40.5002.333Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
77 SEMG1interactor100Semenogelin (PF05474, IPR008836): Semenogelin
78 SETXinteractor21.0000ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
79 SLC4A1oncoprotein40.6670.667Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
HCO3_cotransp (PF00955, IPR011531): HCO3- transporter family
80 SRPK2oncoprotein50.5002.500DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
81 SUMF2interactor21.0000FGE-sulfatase (PF03781, IPR005532): Sulfatase-modifying factor enzyme 1
82 SYVN1interactor40.6670.667Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
83 TGFBR1oncoprotein21.0000Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
84 TGFBR2suppressor40.5002.667ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
85 TNFoncoprotein60.8001.000TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
86 TNIKinteractor30.6670.667CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499)
CNDH2_M (PF16869): PF16858
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
87 TSC22D4interactor60.4676.500AflR (PF08493, IPR013700): Aflatoxin regulatory protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
88 TTRinteractor50.5002.667Transthyretin (PF00576, IPR023416, SM00095): HIUase/Transthyretin family
89 TUBB6interactor60.5333.753Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
90 TUBGCP5interactor21.0000Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
GCP5-Mod21 (PF14609, IPR032797): gamma-Tubulin ring complex non-core subunit mod21
91 TUFMinteractor80.5005.855GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
92 UBCprotein found in more fusions200.193114.006ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
93 VHLsuppressor40.6670.333Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
94 XPO1interactor170.16298.473CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
95 XRCC6oncoprotein90.46410.783Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
96 ZWINTinteractor40.6671.000Zwint (PF15556, IPR029092): ZW10 interactor

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BAXsuppressorBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
2 CLUparental proteinClusterin (PF01093, IPR000753): Clusterin
3 CYP2E1interactorp450 (PF00067, IPR001128): Cytochrome P450
4 FOSoncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
5 GINM1interactorNA
6 HSPA1LinteractorHSP70 (PF00012, IPR013126): Hsp70 protein
7 HSPA5oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
8 MAP1LC3AinteractorAtg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like

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