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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BP347159 is the fusion of parental proteins AGT, GGCT (from a repository: Fri Jul 19 11:00:46 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins6 (27.27 %)
The number (and %) of the tumor suppressors4 (18.18 %)
Total number of binary PPIs (saturation %)43 (18.61 %)
The number (and %) of affected PPIs21 (48.84 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI2.909
Assortativity coefficient-0.3179
The network average Clustering coefficient0.596
The number (and %) of a zero Clustering coefficients6 (27.27 %)
The number (and %) of a zero Betweenness Centrality16 (72.73 %)


List of the fusions

PPI for parental proteins: AGT,GGCT All fusions
: BP347159;
Proteins found in more fusions MME (see 1 fusions); EWSR1 (see 2 fusions); APP (see 4 fusions); ITSN2 (see 1 fusions); TP53 (see 3 fusions); GRB2 (see 1 fusions); ITPA (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BP347159chimera210.052388.000GGACT (PF06094, IPR009288): Gamma-glutamyl cyclotransferase, AIG2-like
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
AIG2_2 (PF13772): AIG2-like family
2 ACEinteractor21.0000Peptidase_M2 (PF01401, IPR001548): Angiotensin-converting enzyme
3 ACE2interactor200Peptidase_M2 (PF01401, IPR001548): Angiotensin-converting enzyme
Collectrin (PF16959, IPR031588): Renal amino acid transporter
4 APPprotein found in more fusions31.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATP6AP2interactor40.6671.000Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
6 ECE1interactor100Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
7 EWSR1oncoprotein40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 FBXW7suppressor200Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
9 GRB2oncoprotein31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
10 GSDMBinteractor21.0000Gasdermin (PF04598, IPR007677): Gasdermin family
11 HECW2interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
12 ITPAprotein found in more fusions31.0000Ham1p_like (PF01725, IPR002637): Ham1 family
13 ITSN2protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
14 MMEsuppressor200Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
15 RASSF10suppressor21.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
16 RASSF7interactor30.6671.000RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SlyX (PF04102, IPR007236): SlyX
Tryp_alpha_amyl (PF00234, IPR016140, SM00499): Protease inhibitor/seed storage/LTP family
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
17 RASSF9interactor21.0000RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB)
DUF3087 (PF11286, IPR021438): Protein of unknown function (DUF3087)
18 RENinteractor21.0000A1_Propeptide (PF07966, IPR012848): A1 Propeptide
Asp (PF00026, IPR001461): Eukaryotic aspartyl protease
19 SCLYinteractor21.0000Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
20 TP53suppressor40.6671.000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
21 TSNAXinteractor100Translin (PF01997, IPR002848): Translin family
22 WDR1interactor50.4006.000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AGTparental proteinNuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
2 GGCTparental proteinGGACT (PF06094, IPR009288): Gamma-glutamyl cyclotransferase, AIG2-like
AIG2_2 (PF13772): AIG2-like family

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