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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BP334116 is the fusion of parental proteins RIMS1, HTN3 (from a repository: Wed Feb 7 18:01:57 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)6
The number (and %) of the onco-proteins3 (50.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)8 (53.33 %)
The number (and %) of affected PPIs5 (62.50 %)
The number of possible different fusions1
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.4472
The network average Clustering coefficient0.350
The number (and %) of a zero Clustering coefficients3 (50.00 %)
The number (and %) of a zero Betweenness Centrality5 (83.33 %)


List of the fusions

PPI for parental proteins: HTN3,RIMS1 All fusions
: BP334116;
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BP334116chimera50.10018.000C2 (PF00168, IPR000008, SM00239): C2 domain
2 ERC2oncoprotein1003HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
3 LRRK1interactor200Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
4 MYH1oncoprotein21.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
5 PDK1interactor31.0000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
6 UNC13Binteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF1041 (PF06292, IPR010439, SM01145): Domain of Unknown Function (DUF1041)
Membr_traf_MHD (PF10540, IPR019558): Munc13 (mammalian uncoordinated) homology domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BSNinteractorDUF547 (PF04784, IPR006869): Protein of unknown function, DUF547
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
zf-piccolo (PF05715, IPR008899): Piccolo Zn-finger
DUF4763 (PF15960, IPR031883): Domain of unknown function (DUF4763)
2 CAMK2AinteractorCaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
3 HSPA8oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
4 HTN3parental proteinAJAP1_PANP_C (PF15298, IPR029198): AJAP1/PANP C-terminus
5 KRASoncoproteinRas (PF00071, IPR001806, SM00173): Ras family
6 RAB3AoncoproteinG-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
Ras (PF00071, IPR001806, SM00173): Ras family
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)
7 RIMS1parental proteinC2 (PF00168, IPR000008, SM00239): C2 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
8 YWHAHinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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