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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BP314848 is the fusion of parental proteins HIST1H2BE, PGM3 (from a repository: Tue May 21 09:39:32 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins9 (42.86 %)
The number (and %) of the tumor suppressors1 (4.76 %)
Total number of binary PPIs (saturation %)43 (20.48 %)
The number (and %) of affected PPIs20 (46.51 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.143
Assortativity coefficient-0.3641
The network average Clustering coefficient0.459
The number (and %) of a zero Clustering coefficients7 (33.33 %)
The number (and %) of a zero Betweenness Centrality12 (57.14 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: HIST1H2BE,PGM3 All fusions
: BP314848;
Proteins found in more fusions APP (see 4 fusions); MCM2 (see 1 fusions); CUL3 (see 1 fusions); GAN (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BP314848chimera200.068338.500PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
2 APPprotein found in more fusions50.5002.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 BAG3oncoprotein31.0000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
4 CD81interactor40.6671.000Tetraspannin (PF00335, IPR018499): Tetraspanin family
5 CUL3protein found in more fusions60.4005.500Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
6 DCP2interactor100DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
7 ENOPH1interactor30.6671.000Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
8 ESR1suppressor31.0000Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
9 GANprotein found in more fusions31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
10 GLO1interactor100Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
11 ICAM1oncoprotein100Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
12 IGSF8oncoprotein21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
13 ITGA4interactor40.6671.000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
14 LACTB2interactor100E2_bind (PF08825, IPR014929): E2 binding domain
Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
15 MCM2oncoprotein50.5002.500AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
16 NTRK1oncoprotein50.5002.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
17 PGM1interactor30.6670.500PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
18 PGM5interactor100PGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879, IPR005845): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
19 PUDPinteractor21.0000Hydrolase_like (PF13242): HAD-hyrolase-like
HAD_2 (PF13419, IPR023214): Haloacid dehalogenase-like hydrolase
20 SPRTNinteractor100GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
21 UAP1interactor200UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 HDGFinteractorPWWP (PF00855, IPR000313, SM00293): PWWP domain
2 HIST1H2BEparental proteinHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
3 PGM3parental proteinPGM_PMM_I (PF02878, IPR005844): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_III (PF02880, IPR005846): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408, IPR005843): Phosphoglucomutase/phosphomannomutase, C-terminal domain
Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e

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