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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BP283815 is the fusion of parental proteins RPL28, ALDOA (from a repository: Wed Feb 15 14:52:01 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)157
The number (and %) of the onco-proteins34 (21.66 %)
The number (and %) of the tumor suppressors20 (12.74 %)
Total number of binary PPIs (saturation %)2096 (17.12 %)
The number (and %) of affected PPIs156 (7.44 %)
The number of possible different fusions27
PPI diameter2
PPI radius1
The average degree of PPI26.013
Assortativity coefficient-0.0887
The network average Clustering coefficient0.539
The number (and %) of a zero Clustering coefficients6 (3.82 %)
The number (and %) of a zero Betweenness Centrality15 (9.55 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ALDOA,RPL28 All fusions
: BP283815;
Proteins found in more fusions SMAD4 (see 2 fusions); SOD2 (see 3 fusions); CUL1 (see 3 fusions); FANCA (see 1 fusions); HDAC5 (see 1 fusions); PCNA (see 1 fusions); RPLP2 (see 1 fusions); SUZ12 (see 2 fusions); TKT (see 5 fusions); HSP90AA1 (see 2 fusions); HUWE1 (see 2 fusions); HSP90AB1 (see 1 fusions); SRPK2 (see 1 fusions); ECHS1 (see 1 fusions); KCNAB2 (see 1 fusions); RPS19/RPS14 (see 1 fusions); GAPDH (see 2 fusions); CUL3 (see 1 fusions); MYC (see 1 fusions); KIF11 (see 1 fusions); COPS5 (see 1 fusions); UBC (see 1 fusions); TP53 (see 3 fusions); FUS/PKM (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BP283815chimera1560.15611024.018FTZ (PF03867, IPR005567): Fushi tarazu (FTZ), N-terminal region
Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
Ribosomal_L28e (PF01778, IPR029004): Ribosomal L28e protein family
2 ACAA2interactor130.53815.326Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3 ACO2interactor120.33326.336Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
4 ACTN4interactor160.37521.201CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
5 ADI1interactor40.6671.333ARD (PF03079, IPR004313): ARD/ARD' family
6 ADRB2interactor110.5335.0937tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7 AHSA1interactor280.60622.047Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
8 AKT1oncoprotein150.39619.276PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
9 ALDOBoncoprotein21.0000Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
10 ALDOCinteractor340.171336.981Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
11 ARHGDIAinteractor150.30831.385Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
12 ARRB2interactor280.48947.979Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
13 ASS1suppressor130.40915.185Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
14 ATF2oncoprotein170.42522.876bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
15 ATP5Jinteractor40.6671.000ATP-synt_F6 (PF05511, IPR008387): Mitochondrial ATP synthase coupling factor 6
16 ATP6V1E1interactor40.5003.000vATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit
17 BCAT2interactor200Aminotran_4 (PF01063, IPR001544): Amino-transferase class IV
18 BRCA1suppressor260.30398.291BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
19 CACNA1Ainteractor100Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
Roughex (PF06020, IPR009259): Drosophila roughex protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
20 CAND1interactor580.576131.076Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
21 CCDC8interactor320.46245.804Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
22 CCNDBP1suppressor31.0000CheF-arch (PF04283, IPR007381): Chemotaxis signal transduction system protein F from archaea
GCIP (PF13324): Grap2 and cyclin-D-interacting
23 CDK2suppressor570.424253.613Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
24 CFL1interactor270.44755.145Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
25 CKBinteractor220.24280.348ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
26 CKMT1Ainteractor70.3816.306ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
27 CKMT1Binteractor80.3576.235ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
28 CKMT2interactor40.5001.567ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
29 COPS5protein found in more fusions530.566150.398JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
30 CUL1suppressor550.516184.773Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
31 CUL2suppressor440.59574.411Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
32 CUL3protein found in more fusions660.416423.816Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
33 CUL4Boncoprotein370.61936.594Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
34 DCCsuppressor61.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neogenin_C (PF06583, IPR010560): Neogenin C-terminus
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
35 DRC1interactor100GvpK (PF05121, IPR007805): Gas vesicle protein K
Octopine_DH (PF02317, IPR003421): NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain
ApoO (PF09769, IPR019166): Apolipoprotein O
NYD-SP28 (PF14772): Sperm tail
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
LRR19-TM (PF15176): Leucine-rich repeat family 19 TM domain
36 ECHS1protein found in more fusions60.6003.167ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
37 EGFRoncoprotein320.310131.748Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
38 EIF4A3interactor300.53043.402DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
39 ENO1oncoprotein480.268408.483Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
40 ESR1suppressor450.445151.505Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
41 FANCAoncoprotein70.8000.455Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein
Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
42 FBXO6interactor320.351102.209FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
43 FHsuppressor130.48717.604Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
44 FKBP2interactor90.7224.378FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
45 FKBP7interactor50.6001.654FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
46 FN1oncoprotein580.400275.668fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
47 FUSsuppressor370.48992.140Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
48 GALNT6interactor100Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase
Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
Ricin_B_lectin (PF00652, IPR000772, SM00458): Ricin-type beta-trefoil lectin domain
49 GAPDHoncoprotein480.325296.082Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
50 GLO1interactor80.4298.261Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
51 GPD1Linteractor80.4647.956NAD_Gly3P_dh_C (PF07479, IPR006109): NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
52 GPX4interactor110.6188.766GSHPx (PF00255, IPR000889): Glutathione peroxidase
53 GRSF1interactor80.8570.519RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
VWA_N2 (PF16164, IPR032361): VWA N-terminal
54 GTF2Iinteractor120.47011.287GTF2I (PF02946, IPR004212): GTF2I-like repeat
55 H2AFXsuppressor220.39439.228Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
56 HDAC5protein found in more fusions310.36373.552Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
57 HNRNPA1interactor520.399225.536RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
58 HNRNPUinteractor560.571157.866CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
59 HSD17B10interactor250.38369.148adh_short (PF00106, IPR002198): short chain dehydrogenase
60 HSP90AA1oncoprotein560.361355.877HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
61 HSP90AB1oncoprotein480.464124.559HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
62 HSPB2interactor80.3818.475Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
63 HSPD1suppressor350.348113.881Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
64 HSPE1interactor240.261114.297Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
65 HUWE1oncoprotein460.426118.494BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
66 IFNA4interactor100Interferon (PF00143, IPR000471, SM00076): Interferon alpha/beta domain
67 IMPA2interactor70.6672.400Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
68 IQCB1interactor100.5117.424DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
69 ISG15suppressor160.44218.458ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
70 ITGA4interactor480.466131.883FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
71 KCNAB2protein found in more fusions31.0000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
72 KIF11protein found in more fusions110.5563.716Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
73 LDHAinteractor350.41990.981Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
74 LGALS1interactor110.34516.619Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
75 LIG4interactor70.5711.607APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
76 LMAN1interactor60.5332.160Lectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
77 LTA4Hinteractor60.5332.656Leuk-A4-hydro_C (PF09127, IPR015211): Leukotriene A4 hydrolase, C-terminal
Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
78 MAGEB2interactor100.9780.059MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
79 MAGOHinteractor170.64018.824Mago_nashi (PF02792, IPR004023): Mago nashi protein
80 MAP2K5oncoprotein40.6670.069PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
81 MAP2K7interactor60.6671.239Pkinase (PF00069, IPR000719): Protein kinase domain
82 MCM2oncoprotein560.451185.926AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
83 MLH1suppressor90.4726.777DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
84 MYConcoprotein220.41443.522HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
85 MYH7Binteractor60.8001.452Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
YkuI_C (PF10388, IPR018842): EAL-domain associated signalling protein domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
86 MYOCinteractor70.9330.077IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
87 NCAPHinteractor50.6000.523Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
88 NCSTNinteractor60.6000.661Nicastrin (PF05450, IPR008710): Nicastrin
Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
89 NTRK1oncoprotein710.265863.976I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
90 OSBPL10interactor21.0000Flagellar_rod (PF05149, IPR007824): Paraflagellar rod protein
Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH_8 (PF15409): Pleckstrin homology domain
91 PA2G4interactor190.45022.478Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
92 PAN2interactor360.70030.931RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
93 PCNAoncoprotein240.44337.785PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
94 PCSK9interactor100Peptidase_S8 (PF00082, IPR000209): Subtilase family
Inhibitor_I9 (PF05922, IPR010259): Peptidase inhibitor I9
95 PGAM2interactor50.6000.813His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
96 PGK1interactor270.50159.282PGK (PF00162, IPR001576): Phosphoglycerate kinase
97 PIAS4interactor50.6002.733CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
98 PKMoncoprotein380.374142.897PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
99 PLD2interactor50.7000.318PH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
100 PREPinteractor70.4767.495Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
Peptidase_S9_N (PF02897, IPR023302): Prolyl oligopeptidase, N-terminal beta-propeller domain
101 PSMA3interactor250.50435.156Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
102 PSMD4interactor130.43622.297UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
103 RAD52oncoprotein80.4291.638Rad52_Rad22 (PF04098, IPR007232): Rad52/22 family double-strand break repair protein
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
104 RNF2interactor320.48671.977zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
105 RPL13interactor530.65277.591Ribosomal_L13e (PF01294, IPR001380): Ribosomal protein L13e
106 RPL14interactor500.70346.731KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
107 RPL19interactor460.74934.069DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e
108 RPL21interactor510.67760.619Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
109 RPL23interactor490.70476.308Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
110 RPL23Ainteractor500.71350.046Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
111 RPL34interactor360.77527.676Redoxin (PF08534, IPR013740): Redoxin
Ribosomal_L34e (PF01199, IPR008195): Ribosomal protein L34e
112 RPL35interactor390.8588.387Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein
XFP_N (PF09364, IPR018970): XFP N-terminal domain
113 RPL36interactor430.79719.501Ribosomal_L36e (PF01158, IPR000509): Ribosomal protein L36e
114 RPL38interactor420.75531.844Ribosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
115 RPL5suppressor530.69253.522Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
116 RPL7interactor520.69043.297Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e
Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
117 RPL8interactor510.69144.804Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
118 RPLP0interactor560.65590.570Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
119 RPLP1interactor390.80823.311Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
120 RPLP2protein found in more fusions470.69947.717Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
121 RPS11interactor520.641115.132Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17
Ribosomal_S17_N (PF16205, IPR032440): Ribosomal_S17 N-terminal
122 RPS14protein found in more fusions520.68961.761Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
123 RPS15interactor370.82912.547Ribosomal_S19 (PF00203, IPR002222): Ribosomal protein S19
Prok_Ub (PF14454, IPR032866): Prokaryotic Ubiquitin
124 RPS15Ainteractor470.75825.250Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
125 RPS16interactor520.70648.209Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
126 RPS19protein found in more fusions470.70274.178Ribosomal_S19e (PF01090, IPR001266): Ribosomal protein S19e
127 RPS2interactor540.65965.233Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
128 RPS23interactor440.76826.822Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
129 RPS25interactor470.77619.847Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
130 RPS3interactor560.66255.858KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
131 RPS3Ainteractor580.627113.572Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
132 RPS6interactor550.634119.441Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
133 SMAD4suppressor120.27319.642MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
134 SOD2suppressor110.40013.625Sod_Fe_C (PF02777, IPR019832): Iron/manganese superoxide dismutases, C-terminal domain
Sod_Fe_N (PF00081, IPR019831): Iron/manganese superoxide dismutases, alpha-hairpin domain
135 SRPK2oncoprotein150.48410.458DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
136 SUMO2interactor80.4765.767Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
137 SUMO4interactor31.0000SRP9-21 (PF05486): Signal recognition particle 9 kDa protein (SRP9)
Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
138 SUZ12suppressor110.42210.156DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
139 TAGLNsuppressor100.6005.967Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
140 TAGLN2interactor200.43244.362Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
141 TALDO1interactor110.52711.228TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
142 TARDBPinteractor410.62360.834RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
143 TDRD3interactor40.6670.491RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
TUDOR (PF00567, IPR002999, SM00333): Tudor domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
DUF3472 (PF11958, IPR021862): Domain of unknown function (DUF3472)
144 TERF1interactor210.34737.187TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
145 TKTprotein found in more fusions320.363121.900Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
146 TNPO3interactor31.0000HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
147 TP53suppressor460.504147.454DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
148 TRAP1oncoprotein150.42916.610HSP90 (PF00183, IPR001404): Hsp90 protein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
149 TRIM63interactor80.3335.461DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
KIP1 (PF07765, IPR011684): KIP1-like protein
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
150 UBCprotein found in more fusions390.344178.877ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
151 UBL4Ainteractor350.68738.619ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
152 UMPSinteractor60.4673.246OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
153 USP15oncoprotein150.46224.322UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
154 VCAM1interactor450.470130.515C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
155 VCPKMTinteractor21.0000Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
156 VPS18interactor31.0000Pep3_Vps18 (PF05131, IPR007810): Pep3/Vps18/deep orange family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
157 XPO1interactor350.474103.019CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ALDOAparental proteinGlycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
2 CDK2AP1suppressorCDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
3 COX4I1interactorCOX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
4 CSinteractorCitrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain
5 DUTinteractordUTPase (PF00692, IPR008180): dUTPase
6 FABP5interactorLipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
7 ISYNA1interactorNAD_binding_5 (PF07994, IPR002587): Myo-inositol-1-phosphate synthase
8 NDUFS4interactorETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
9 RPL28parental proteinRibosomal_L28e (PF01778, IPR029004): Ribosomal L28e protein family
10 RPL3interactorRibosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
11 RPS10interactorS10_plectin (PF03501, IPR005326): Plectin/S10 domain
12 RPS18interactorRibosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
13 RPS29interactorRibosomal_S14 (PF00253, IPR001209): Ribosomal protein S14p/S29e
14 XRN1interactorXRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus

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