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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BP274873 is the fusion of parental proteins SNX12, RMND5B (from a repository: Fri Mar 3 10:01:37 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins7 (30.43 %)
The number (and %) of the tumor suppressors3 (13.04 %)
Total number of binary PPIs (saturation %)54 (21.34 %)
The number (and %) of affected PPIs22 (40.74 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI3.391
Assortativity coefficient-0.2582
The network average Clustering coefficient0.470
The number (and %) of a zero Clustering coefficients7 (30.43 %)
The number (and %) of a zero Betweenness Centrality11 (47.83 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SNX12,RMND5B All fusions
: BP274873;
Proteins found in more fusions EWSR1 (see 2 fusions); SMAD4 (see 2 fusions); UBE2E1 (see 2 fusions); TP53 (see 3 fusions); UBE2D2 (see 2 fusions); AHCYL1 (see 3 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BP274873chimera220.074399.000Sec15 (PF04091, IPR007225): Exocyst complex subunit Sec15-like
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
2 AHCYL1suppressor70.4009.000AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
3 CDC5Linteractor40.6671.000OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
4 CDK9protein found in more fusions40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
5 DAZAP1interactor30.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
6 DLDinteractor100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
7 EWSR1oncoprotein70.33310.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 HGSinteractor30.6671.000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
9 IGBP1interactor21.0000TAP42 (PF04177, IPR007304): TAP42-like family
10 MRPL4interactor21.0000Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
11 PPM1Ginteractor30.6671.000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PP2C (PF00481, IPR001932): Protein phosphatase 2C
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
12 PSMC1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
13 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
14 SMAD4suppressor40.6671.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
15 SOX2oncoprotein40.6671.000HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
16 TP53suppressor40.6671.000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
17 UBE2D2oncoprotein41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
18 UBE2D3interactor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
19 UBE2D4interactor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
20 UBE2E1protein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
21 UBE2E3interactor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
22 UBE2L3interactor50.6672.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
23 UBE2Winteractor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AKR1A1interactorAldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
2 APRTinteractorPribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
3 ARL6IP1interactorReticulon (PF02453, IPR003388): Reticulon
TraG_N (PF07916, IPR012931): TraG-like protein, N-terminal region
4 CLNS1AinteractorVoldacs (PF03517): Regulator of volume decrease after cellular swelling
5 GNPDA2interactorGlucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
6 IFI30oncoproteinGILT (PF03227, IPR004911): Gamma interferon inducible lysosomal thiol reductase (GILT)
7 MTAPsuppressorPNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
8 NME1-NME2interactorNDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
9 PIN1suppressorRotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
10 PPIL3interactorPro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
11 PPP4R3AinteractorCollagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
WH1 (PF00568, IPR000697, SM00461): WH1 domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
12 RMND5Bparental proteinSec15 (PF04091, IPR007225): Exocyst complex subunit Sec15-like
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
13 RTN4suppressorCENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
14 SNX12parental proteinPX (PF00787, IPR001683, SM00312): PX domain
15 TAGLNsuppressorCalponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
16 TAGLN2interactorCalponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
17 TAGLN3interactorCalponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain

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