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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BP231880 is the fusion of parental proteins STAMBPL1, FAT4 (from a repository: Wed Dec 11 18:20:57 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)5
The number (and %) of the onco-proteins2 (40.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)6 (60.00 %)
The number (and %) of affected PPIs4 (66.67 %)
The number of possible different fusions1
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.4082
The network average Clustering coefficient0.433
The number (and %) of a zero Clustering coefficients2 (40.00 %)
The number (and %) of a zero Betweenness Centrality4 (80.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: FAT4,ACTA2 All fusions
: BP231880;
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BP231880chimera40.16710.000Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
2 CEACAM21interactor21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
3 DDX39Ainteractor200DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
4 NXPH2interactor100Neurexophilin (PF06312, IPR026845): Neurexophilin
5 RYKoncoprotein21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 A2MinteractorA2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
2 ATXN1interactorAXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
3 C2orf48interactorNA
4 CAPZA2interactorF-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
5 CC2D2AinteractorC2 (PF00168, IPR000008, SM00239): C2 domain
ZnuA (PF01297, IPR006127): Zinc-uptake complex component A periplasmic
DUF4240 (PF14024, IPR025334): Protein of unknown function (DUF4240)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
CC2D2AN-C2 (PF15625, IPR028928): CC2D2A N-terminal C2 domain
6 CDC37interactorCDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
7 CEP72interactorLRR_9 (PF14580): Leucine-rich repeat
FAM76 (PF16046, IPR032017): FAM76 protein
8 CLINT1interactorENTH (PF01417, IPR001026, SM00273): ENTH domain
9 CLTConcoproteinClathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
10 ECSITinteractorECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
11 ENO1oncoproteinEnolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
12 FAT4parental proteinEGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
FOLN (PF09289, IPR015369, SM00274): Follistatin/Osteonectin-like EGF domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Cadherin_3 (PF16184): Cadherin-like
13 GAKoncoproteinDnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
14 GNPTABinteractorDMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
Notch (PF00066, IPR000800, SM00004): LNR domain
Stealth_CR2 (PF11380, IPR021520): Stealth protein CR2, conserved region 2
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
Stealth_CR1 (PF17101, IPR031358): Stealth protein CR1, conserved region 1
Stealth_CR3 (PF17102, IPR031357): Stealth protein CR3, conserved region 3
Stealth_CR4 (PF17103, IPR031356): Stealth protein CR4, conserved region 4
15 GOLGA2interactorATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
16 GTSE1interactorGTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
17 HMX3interactorRibosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Shadoo (PF14999, IPR029238): Shadow of prion protein, neuroprotective
PRIMA1 (PF16101): Proline-rich membrane anchor 1
18 IKZF3suppressorC1_2 (PF03107, IPR004146): C1 domain
Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
19 INCA1interactorINCA1 (PF15142, IPR026238): INCA1
20 LAX1interactorLAX (PF15681, IPR031393): Lymphocyte activation family X
21 MAGEA6interactorMAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
22 MAST1interactorDUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
23 NXF1interactorNTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
24 OTUB1interactorPeptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
25 PNMA1oncoproteinPNMA (PF14893, IPR026523): PNMA
26 PSEN1oncoproteinPresenilin (PF01080, IPR001108): Presenilin
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
27 RAB2AoncoproteinRas (PF00071, IPR001806, SM00173): Ras family
28 RNF32interactorIQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
29 SHMT2interactorSHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
30 SNRPA1interactorLRR_9 (PF14580): Leucine-rich repeat
31 STAMBPL1parental proteinCHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
32 TCF4suppressorCDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
33 TRIM27oncoproteinIncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
34 TRIP13interactorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
35 UBCinteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
36 UBE2NinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
37 USP49interactorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein

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