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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BP229393 is the fusion of parental proteins DDAH2, TTC7B (from a repository: Tue May 9 01:19:07 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins7 (41.18 %)
The number (and %) of the tumor suppressors3 (17.65 %)
Total number of binary PPIs (saturation %)29 (21.32 %)
The number (and %) of affected PPIs16 (55.17 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.941
Assortativity coefficient-0.2275
The network average Clustering coefficient0.455
The number (and %) of a zero Clustering coefficients6 (35.29 %)
The number (and %) of a zero Betweenness Centrality10 (58.82 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: TTC7B,DDAH2 All fusions
: BP229393;
Proteins found in more fusions CUL3 (see 1 fusions); TSC22D1 (see 5 fusions); ZAK (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BP229393chimera160.075213.333HrpB1_HrpK (PF09613, IPR013394): Bacterial type III secretion protein (HrpB1_HrpK)
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
2 CDC73suppressor100CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
3 CDK4oncoprotein21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
4 CUL3protein found in more fusions50.5003.000Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
5 DNAJB11interactor21.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
6 FKBP1Binteractor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
7 FN1oncoprotein40.5002.667fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
8 GADD45Gsuppressor100Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
9 MKNK1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
10 RAP1Boncoprotein30.6670.667Ras (PF00071, IPR001806, SM00173): Ras family
11 RCC1interactor30.6670.667RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
12 RPS6KA1oncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
13 RPS6KA5interactor30.6671.000Choline_kinase (PF01633): Choline/ethanolamine kinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
14 TRIP13interactor31.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
15 TSC22D1suppressor200SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
16 VCAM1interactor30.6670.667C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
17 ZAKprotein found in more fusions31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ANXA7suppressorAnnexin (PF00191, IPR018502, SM00335): Annexin
2 ATP1B1interactorNa_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
3 CDKN1AsuppressorCDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
4 CLNS1AinteractorVoldacs (PF03517): Regulator of volume decrease after cellular swelling
5 DDAH1interactorAmidinotransf (PF02274, IPR003198): Amidinotransferase
6 DDAH2parental proteinAmidinotransf (PF02274, IPR003198): Amidinotransferase
7 EPB41L1interactor4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
8 EPB41L2interactor4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DUF966 (PF06136, IPR010369): Domain of unknown function (DUF966)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
SAB (PF04382, IPR007477): SAB domain
TCP (PF03634, IPR005333): TCP family transcription factor
9 EPB41L3suppressor4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
10 HCFC1interactorfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
11 OGTinteractorTPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
12 PIN1suppressorRotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
13 PPA1interactorPyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
14 SMN1interactorSMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
15 STK3interactorPkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
16 TAF1DinteractorTAF1D (PF15333, IPR027976): TATA box-binding protein-associated factor 1D
17 TK1oncoproteinTK (PF00265, IPR001267, SM00203): Thymidine kinase
18 TNFSF11interactorTNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
DUF2735 (PF10931, IPR021232): Protein of unknown function (DUF2735)
19 TTC7Bparental proteinHrpB1_HrpK (PF09613, IPR013394): Bacterial type III secretion protein (HrpB1_HrpK)
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Deme6 (PF10300, IPR019412): Protein of unknown function (DUF3808)
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
20 VAC14oncoproteinTAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fig4_bd (PF11916, IPR021841): Vacuolar protein 14 C-terminal Fig4p binding
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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