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Visualization interactions

Powered by Cytoscape Web for: BM979210 is the fusion of parental proteins ATP6V1C1 (from a repository: Sun Feb 5 11:27:41 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)50
The number (and %) of the onco-proteins9 (18.00 %)
The number (and %) of the tumor suppressors2 (4.00 %)
Total number of binary PPIs (saturation %)183 (14.94 %)
The number (and %) of affected PPIs49 (26.78 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI6.880
Assortativity coefficient-0.3718
The network average Clustering coefficient0.642
The number (and %) of a zero Clustering coefficients5 (10.00 %)
The number (and %) of a zero Betweenness Centrality16 (32.00 %)


List of the fusions

PPI for parental proteins: ATP6V1C1 All fusions
: BM979210;
Proteins found in more fusions TSN (see 1 fusions); LUC7L2 (see 2 fusions); IVNS1ABP (see 2 fusions); VPS35 (see 2 fusions); STAT1 (see 1 fusions); SNX1 (see 1 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BM979210chimera490.1051790.744V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
2 ABCD3interactor21.0000ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
3 ANP32Einteractor70.6673.900BUD22 (PF09073, IPR015158): BUD22
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
4 ARFIP1interactor90.50012.800Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
5 ATG7interactor130.60314.739ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
6 ATL3interactor21.0000GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
7 ATP6AP1interactor30.6670.667ATP-synt_S1 (PF05827, IPR024722): Vacuolar ATP synthase subunit S1 (ATP6S1)
8 ATP6AP2interactor50.5002.667Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
9 ATP6V1B1interactor21.0000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
10 ATP6V1E1interactor30.6671.000vATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit
11 CISD1interactor100zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MitoNEET_N (PF10660, IPR019610): Iron-containing outer mitochondrial membrane protein N-terminus
12 CPT1Ainteractor21.0000Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
CPT_N (PF16484, IPR032476): Carnitine O-palmitoyltransferase N-terminus
13 CTTNoncoprotein140.57719.853FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14 DNM1Linteractor51.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
AAA_16 (PF13191): AAA ATPase domain
15 GSPT1oncoprotein80.8211.750GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
16 GSPT2interactor120.6828.687GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
17 HDDC3interactor100HD_4 (PF13328, IPR003607): HD domain
18 IDEinteractor100.6228.219Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
19 IVNS1ABPprotein found in more fusions50.8330.500BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
20 LAMTOR5interactor30.6670.667LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
21 LUC7L2protein found in more fusions70.5334.733LUC7 (PF03194, IPR004882): LUC7 N_terminus
Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
22 MGST3interactor100MAPEG (PF01124, IPR001129): MAPEG family
23 MOV10interactor110.20041.667AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
24 MRPS35interactor100MRP-S28 (PF10213, IPR019349): Mitochondrial ribosomal subunit protein
25 NASPinteractor60.8001.833Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
SlyX (PF04102, IPR007236): SlyX
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
XhlA (PF10779, IPR019715): Haemolysin XhlA
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
26 NDUFA9interactor21.0000Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
27 PAWRsuppressor80.8211.618ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
28 PHB2interactor30.6671.000DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
29 PPP2R1Aoncoprotein100TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
30 PSMG3interactor50.9000.500PAC3 (PF10178, IPR018788): Proteasome assembly chaperone 3
31 RDXinteractor70.8571.400ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
32 SARSinteractor60.6003.267NOD (PF06816, IPR010660): NOTCH protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
33 SEC31Ainteractor30.6670.400P3A (PF08727, IPR014838): Poliovirus 3A protein like
SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1)
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
34 SHMT1interactor130.62112.589SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
35 SHMT2interactor180.37369.040SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
36 SNX1protein found in more fusions140.57718.391PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
37 SNX2interactor160.48333.993PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
38 SNX6interactor120.63610.537PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
39 SRSF5interactor21.0000DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
40 SSR1interactor30.6671.000TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
41 STAT1suppressor140.65411.291SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
42 TBC1D15interactor80.50010.765Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
43 TSNprotein found in more fusions61.0000Translin (PF01997, IPR002848): Translin family
44 TXNDC17interactor21.0000DUF953 (PF06110, IPR010357): Eukaryotic protein of unknown function (DUF953)
Glutaredoxin (PF00462, IPR002109): Glutaredoxin
45 TYMSinteractor30.6671.000Thymidylat_synt (PF00303, IPR000398): Thymidylate synthase
46 UBAC2interactor30.6671.000Rhomboid (PF01694, IPR022764): Rhomboid family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
47 VASPinteractor31.0000ASD2 (PF08687, IPR014799): Apx/Shroom domain ASD2
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
48 VPS29interactor90.7503.517Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
49 VPS35protein found in more fusions100.55610.268FerA (PF08165, IPR012560): FerA (NUC095) domain
Vps35 (PF03635, IPR005378): Vacuolar protein sorting-associated protein 35
50 VTA1interactor21.0000Vta1 (PF04652): Vta1 like

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ALDH3A2interactorAldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
2 ATP6V1C1parental proteinV-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
3 ATP6V1C2interactorV-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
4 CDCA3interactorNA
5 GTF2A1oncoproteinTFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
6 RAB14oncoproteinRas (PF00071, IPR001806, SM00173): Ras family
7 SMSinteractorSpermine_synth (PF01564, IPR001045): Spermine/spermidine synthase

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