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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BM979072 is the fusion of parental proteins ATP2A2, ADGRE5 (from a repository: Thu Feb 22 23:42:46 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins8 (36.36 %)
The number (and %) of the tumor suppressors3 (13.64 %)
Total number of binary PPIs (saturation %)38 (16.45 %)
The number (and %) of affected PPIs21 (55.26 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI2.636
Assortativity coefficient-0.4236
The network average Clustering coefficient0.323
The number (and %) of a zero Clustering coefficients12 (54.55 %)
The number (and %) of a zero Betweenness Centrality16 (72.73 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ADGRE5,ATP2A2 All fusions
: BM979072;
Proteins found in more fusions ILK (see 1 fusions); EGFR (see 2 fusions); HNRNPD (see 1 fusions); SKI (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BM979072chimera210.038395.3337tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_MSP1_1 (PF12946, IPR024730): MSP1 EGF domain 1
2 ASB1interactor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
3 ASB14interactor30.6671.000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
4 CFTRsuppressor200ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
5 EGFRoncoprotein40.6670.667Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
6 GOLT1Binteractor30.6670.667Got1 (PF04178, IPR007305): Got1/Sft2-like family
7 HGSinteractor30.6670.667FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
8 HNRNPDoncoprotein31.0000CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
9 ILKsuppressor200Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
10 KNL1oncoprotein100DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
11 LGR4interactor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
12 LPAR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
13 MDM2oncoprotein31.0000Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
14 NOS2interactor200FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
15 NOTCH2suppressor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
16 PKN2interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
17 PTP4A3oncoprotein100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
18 SKIoncoprotein200c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
19 TMEM171interactor100TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
20 TMEM63Binteractor21.0000RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
21 VAPAinteractor50.4005.667DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
22 XRN1interactor100XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ADGRE5parental protein7tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_MSP1_1 (PF12946, IPR024730): MSP1 EGF domain 1
2 ADRB2interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
3 AMFRoncoproteinCUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4 ASB17interactorHTH_Mga (PF08280, IPR013199): M protein trans-acting positive regulator (MGA) HTH domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
SOCS_box (PF07525, IPR001496): SOCS box
5 ASB5interactorAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
6 ATF2oncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
7 ATP1B1interactorNa_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
8 ATP2A2parental proteinCation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
9 CCDC8interactorBorrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
10 CDK1oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
11 CLN3interactorCLN3 (PF02487, IPR003492): CLN3 protein
12 CLN5interactorCLN5 (PF15014, IPR026138): Ceroid-lipofuscinosis neuronal protein 5
13 CUL3interactorCullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
14 CUL7interactorANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
15 ECT2suppressorBRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
16 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
17 ERLIN2interactorBand_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
18 ESRRBsuppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
19 EZH2suppressorCDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
20 FBXO25suppressorElongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
21 HACD3interactorPTPLA (PF04387, IPR007482): Protein tyrosine phosphatase-like protein, PTPLA
22 HDAC5interactorHist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
23 ITPR3interactorDUF1041 (PF06292, IPR010439, SM01145): Domain of Unknown Function (DUF1041)
Ins145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
24 KIF23interactorDUF730 (PF05325, IPR007989): Protein of unknown function (DUF730)
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
25 LMAN1interactorLectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
26 MBOAT1interactorMBOAT (PF03062, IPR004299): MBOAT, membrane-bound O-acyltransferase family
CBP_BcsF (PF11120, IPR019995): Cellulose biosynthesis protein BcsF
DUF3329 (PF11808, IPR021766): Domain of unknown function (DUF3329)
27 MDC1suppressorFHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
28 MTCH2interactorMito_carr (PF00153, IPR018108): Mitochondrial carrier protein
29 NCSTNinteractorNicastrin (PF05450, IPR008710): Nicastrin
Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
30 NDUFS4interactorETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
31 NTRK1oncoproteinI-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32 PLNinteractorPhospholamban (PF04272, IPR005984): Phospholamban
33 RAB7AsuppressorRas (PF00071, IPR001806, SM00173): Ras family
34 RIC3interactorCHASE3 (PF05227, IPR007891): CHASE3 domain
RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3
35 RNF126interactorRad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zinc_ribbon_9 (PF14369): zinc-ribbon
36 RNF2interactorzf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
37 S100A1interactorS_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
38 SIRT7interactorDUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
39 SLC33A1interactorAcatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
40 SLC3A2interactorAlpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain
DUF3459 (PF11941, IPR022567): Domain of unknown function (DUF3459)
SLC3A2_N (PF16028, IPR031984): Solute carrier family 3 member 2 N-terminus
41 SLNinteractorSarcolipin (PF05366, IPR008028): Sarcolipin
42 SPP1oncoproteinOsteopontin (PF00865, IPR002038, SM00017): Osteopontin
43 SPRTNinteractorGreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
44 SUZ12suppressorDUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
45 TCTN2interactorDUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
46 TCTN3interactorDUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
47 TRIM13suppressorATP-synt_E_2 (PF08112, IPR012508): ATP synthase epsilon subunit
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
48 TUBA1CinteractorTubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
49 UNKinteractorMbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
50 UQCRQinteractorUcrQ (PF02939, IPR004205): UcrQ family
51 XRCC3oncoproteinRad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain

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