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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)60
The number (and %) of the onco-proteins11 (18.33 %)
The number (and %) of the tumor suppressors8 (13.33 %)
Total number of binary PPIs (saturation %)691 (39.04 %)
The number (and %) of affected PPIs59 (8.54 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI22.267
Assortativity coefficient-0.2403
The network average Clustering coefficient0.735
The number (and %) of a zero Clustering coefficients3 (5.00 %)
The number (and %) of a zero Betweenness Centrality7 (11.67 %)


List of the fusions

PPI for parental proteins: MED16 All fusions
: BM919198;
Proteins found in more fusions VDR (see 2 fusions); LZTR1 (see 2 fusions); MYC (see 1 fusions); QKI (see 3 fusions); EPAS1 (see 1 fusions); THRA (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BM919198chimera590.356889.028Med16 (PF11635, IPR021665): Mediator complex subunit 16
2 ACVR1interactor200Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
3 AURKAoncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
4 CCNCsuppressor280.8765.677Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
5 CDK19interactor270.9342.389Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
6 CDK8interactor370.69548.104Pkinase (PF00069, IPR000719): Protein kinase domain
7 CEBPEinteractor200Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
8 CTDP1interactor160.9081.301Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
FCP1_C (PF09309, IPR015388): FCP1, C-terminal
NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
9 EFNB2interactor100Ephrin (PF00812, IPR001799): Ephrin
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
10 EMC2interactor60.9330.250TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
11 EPAS1suppressor200.9650.567Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
PAS_11 (PF14598): PAS domain
12 ESR1suppressor240.68823.557Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
13 ESR2suppressor170.9251.844zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
14 FBXW7suppressor280.73540.973Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
15 HECW2interactor60.6002.250C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
16 HNF4Asuppressor120.7822.322zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
17 KAT2Ainteractor120.6558.479Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
18 LZTR1oncoprotein31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
19 MED1interactor510.486206.428Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
20 MED10interactor350.74523.850Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
21 MED11interactor240.9531.281Med11 (PF10280, IPR019404): Mediator complex protein
22 MED12oncoprotein440.555135.521Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877)
Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain
Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
23 MED13oncoprotein340.72528.302Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal
Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
24 MED13Linteractor170.9710.328Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal
Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
25 MED14interactor430.570102.666Med14 (PF08638, IPR013947): Mediator complex subunit MED14
26 MED15interactor350.72437.196Med15 (PF09606, IPR019087): ARC105 or Med15 subunit of Mediator complex non-fungal
27 MED17oncoprotein460.532150.904Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
28 MED18interactor280.9024.258Med18 (PF09637, IPR019095): Med18 protein
29 MED20interactor320.79016.651Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
30 MED23interactor400.64650.797Med23 (PF11573, IPR021629): Mediator complex subunit 23
31 MED24interactor410.60687.239Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
32 MED25interactor280.74915.648Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2
Med25_SD1 (PF11235, IPR021397): Mediator complex subunit 25 synapsin 1
Med25_NR-box (PF11244, IPR021406): Mediator complex subunit 25 C-terminal NR box-containing
Med25_VWA (PF11265, IPR021419): Mediator complex subunit 25 von Willebrand factor type A
33 MED26interactor340.77517.667Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
34 MED27interactor330.80912.691Med27 (PF11571, IPR021627): Mediator complex subunit 27
35 MED28interactor330.83310.374cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
Med28 (PF11594, IPR021640): Mediator complex subunit 28
36 MED29interactor360.77318.011Med29 (PF11568, IPR021018): Mediator complex subunit 29
37 MED30interactor290.8606.313Med30 (PF11315, IPR021019): Mediator complex subunit 30
38 MED4interactor380.70731.299Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
39 MED6interactor370.71533.244Med6 (PF04934, IPR007018): MED6 mediator sub complex component
Peptidase_M15 (PF01427, IPR000755): D-ala-D-ala dipeptidase
40 MED7interactor340.72052.470Med7 (PF05983, IPR009244): MED7 protein
DotU (PF09850, IPR017732): Type VI secretion system protein DotU
41 MED8interactor320.82511.060Med8 (PF10232, IPR019364): Mediator of RNA polymerase II transcription complex subunit 8
42 MED9interactor310.8329.589Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
43 MYConcoprotein120.5276.840HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
44 MYO1Cinteractor50.7000.600IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
45 NTRK1oncoprotein130.50018.693I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
46 OBFC1interactor160.9670.347STN1_2 (PF09170, IPR015253): CST, Suppressor of cdc thirteen homolog, complex subunit STN1
RUN (PF02759, IPR004012, SM00593): RUN domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
Stn1 (PF10451, IPR018856): Telomere regulation protein Stn1
47 POLR2Ginteractor170.8671.899SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
48 PPARGC1Ainteractor110.7643.339Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
49 QKIprotein found in more fusions180.8319.017KH_1 (PF00013, IPR004088, SM00322): KH domain
STAR_dimer (PF16544, IPR032377): Homodimerisation region of STAR domain protein
Quaking_NLS (PF16551, IPR032367): Putative nuclear localisation signal of quaking
50 RALYinteractor50.8000.393RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
51 SUPT3Hinteractor100.8002.318TFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit
DUF4093 (PF13331, IPR025156): Domain of unknown function (DUF4093)
52 SUPT7Linteractor70.9050.472Bromo_TP (PF07524, IPR006565): Bromodomain associated
53 TADA2Ainteractor250.68033.457SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
54 TCL1Boncoprotein140.9890.071TCL1_MTCP1 (PF01840, IPR004832): TCL1/MTCP1 family
55 THRAsuppressor81.0000C1_2 (PF03107, IPR004146): C1 domain
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
56 TRRAPinteractor170.72111.433BALF1 (PF06861, IPR010677): BALF1 protein
BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
ACDC (PF14733, IPR028078): AP2-coincident C-terminal
57 VDRsuppressor130.8033.435zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
58 WBP11interactor40.5001.286BUD22 (PF09073, IPR015158): BUD22
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SspB (PF04386, IPR007481): Stringent starvation protein B
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ABC_trans_N (PF14510, IPR029481): ABC-transporter extracellular N-terminal
59 XRCC3oncoprotein31.0000Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
60 ZC3H13interactor230.87719.872FGF-BP1 (PF06473, IPR010510): FGF binding protein 1 (FGF-BP1)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
PET117 (PF15786, IPR031568): PET assembly of cytochrome c oxidase, mitochondrial

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 FOSL2oncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
2 HIST1H3AinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
3 MED16parental proteinWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Med16 (PF11635, IPR021665): Mediator complex subunit 16
4 MED19interactorMed19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
5 MED21interactorMed21 (PF11221, IPR021384): Subunit 21 of Mediator complex
6 TRAoncoproteinNA

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