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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BM893846 is the fusion of parental proteins IL11, AGAP2 (from a repository: Wed May 10 19:41:49 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)6
The number (and %) of the onco-proteins2 (33.33 %)
The number (and %) of the tumor suppressors1 (16.67 %)
Total number of binary PPIs (saturation %)8 (53.33 %)
The number (and %) of affected PPIs5 (62.50 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI1.667
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients6 (100.00 %)
The number (and %) of a zero Betweenness Centrality5 (83.33 %)


List of the fusions

PPI for parental proteins: AGAP2,IL11 All fusions
: BM893846;
Proteins found in more fusions PIK3R1 (see 1 fusions); NF2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BM893846chimera5020.000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PH (PF00169, IPR001849, SM00233): PH domain
Ras (PF00071, IPR001806, SM00173): Ras family
2 HOMER1interactor100WH1 (PF00568, IPR000697, SM00461): WH1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
3 MAGEA11interactor200MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
4 MPRIPinteractor100Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Fez1 (PF06818): Fez1
FliT (PF05400, IPR008622): Flagellar protein FliT
HalX (PF08663, IPR013971): HalX domain
Mnd1 (PF03962, IPR005647): Mnd1 family
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
YlqD (PF11068, IPR021297): YlqD protein
DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015)
Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
5 NF2suppressor200ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
6 PIK3R1oncoprotein200RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AGAP2parental proteinArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
Ras (PF00071, IPR001806, SM00173): Ras family
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
2 EPB41L1interactor4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
3 IL11parental proteinIL11 (PF07400, IPR020438): Interleukin 11

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